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Publikováno v:
Expert review of anticancer therapy. 22(8)
Decreasing efficacy over time and initial suboptimal response to Janus kinase (JAK) inhibitors such as ruxolitinib in a subset of patients are critical clinical challenges associated with myeloproliferative neoplasms (MPNs), primarily myelofibrosis.T
Autor:
Niccolo Bartalucci
Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written b
Autor:
Niccolo Bartalucci, Lorenzo Galluzzi
Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part A, Volume 365 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release incl
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
The recent development of high-throughput sequencing platforms provided impressive insights into the field of human genetics and contributed to considering structural variants (SVs) as the hallmark of genome instability, leading to the establishment
Externí odkaz:
https://doaj.org/article/b53e3a5e099a43d3b2168a739cda8858
Autor:
Simone Romagnoli, Niccolò Bartalucci, Francesca Gesullo, Manjola Balliu, Stefania Bonifacio, Anair Graciela Lema Fernandez, Francesco Mannelli, Davide Bolognini, Elisabetta Pelo, Cristina Mecucci, Paola Guglielmelli, Alessandro Maria Vannucchi
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-4 (2021)
Abstract Eosinophilia represents a group of diseases with heterogeneous pathobiology and clinical phenotypes. Among the alterations found in primary Eosinophilia, gene fusions involving PDGFRα, PDGFRβ, FGFR1 or JAK2 represent the biomarkers of WHO-
Externí odkaz:
https://doaj.org/article/2cb5613752aa465190f5af029dc11685
Autor:
Elena Genovese, Margherita Mirabile, Sebastiano Rontauroli, Stefano Sartini, Sebastian Fantini, Lara Tavernari, Monica Maccaferri, Paola Guglielmelli, Elisa Bianchi, Sandra Parenti, Chiara Carretta, Selene Mallia, Sara Castellano, Corrado Colasante, Manjola Balliu, Niccolò Bartalucci, Raffaele Palmieri, Tiziana Ottone, Barbara Mora, Leonardo Potenza, Francesco Passamonti, Maria Teresa Voso, Mario Luppi, Alessandro Maria Vannucchi, Enrico Tagliafico, Rossella Manfredini, on behalf of the Mynerva (MYeloid NEoplasms Research Venture AIRC)
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 113 (2022)
Myelofibrosis (MF) is the Philadelphia-negative myeloproliferative neoplasm characterized by the worst prognosis and no response to conventional therapy. Driver mutations in JAK2 and CALR impact on JAK-STAT pathway activation but also on the producti
Externí odkaz:
https://doaj.org/article/753fc1e1ade94842b36e1ec1512b21f5
Autor:
Chiara Rossi, Roberta Zini, Sebastiano Rontauroli, Samantha Ruberti, Zelia Prudente, Greta Barbieri, Elisa Bianchi, Simona Salati, Elena Genovese, Niccolò Bartalucci, Paola Guglielmelli, Enrico Tagliafico, Vittorio Rosti, Giovanni Barosi, Alessandro M. Vannucchi, Rossella Manfredini, the AGIMM (AIRC‐Gruppo Italiano Malattie Mieloproliferative) investigators
Publikováno v:
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by an excessive production of pro‐inflammatory cytokines resulting in chronic inflammation and genomic instability. Besides the driver mutations in JAK2, MPL, and CALR genes
Externí odkaz:
https://doaj.org/article/3988d132e9fe43e8802e4478b3864d42
Autor:
Davide Bolognini, Niccolò Bartalucci, Alessandra Mingrino, Alessandro Maria Vannucchi, Alberto Magi
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216471 (2019)
MinION and GridION X5 from Oxford Nanopore Technologies are devices for real-time DNA and RNA sequencing. On the one hand, MinION is the only real-time, low cost and portable sequencing device and, thanks to its unique properties, is becoming more an
Externí odkaz:
https://doaj.org/article/d50799e48be24049b3d4a39316c7120f
Autor:
Costanza Bogani, Niccolò Bartalucci, Serena Martinelli, Lorenzo Tozzi, Paola Guglielmelli, Alberto Bosi, Alessandro M Vannucchi, Associazione Italiana per la Ricerca sul Cancro AGIMM Gruppo Italiano Malattie Mieloproliferative
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54826 (2013)
BACKGROUND:Dysregulated signaling of the JAK/STAT pathway is a common feature of chronic myeloproliferative neoplasms (MPN), usually associated with JAK2V617F mutation. Recent clinical trials with JAK2 inhibitors showed significant improvements in sp
Externí odkaz:
https://doaj.org/article/be809609d2ff41919619b1559796b443