Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Niccolò Tesi"'
Autor:
Lianne M. Reus, Iris E. Jansen, Merel O. Mol, Fred van Ruissen, Jeroen van Rooij, Natasja M. van Schoor, Niccolò Tesi, Marcel J. T. Reinders, Martijn A. Huisman, Henne Holstege, Pieter Jelle Visser, Sterre C. M. de Boer, Marc Hulsman, Shahzad Ahmad, Najaf Amin, Andre G. Uitterlinden, Arfan Ikram, Cornelia M. van Duijn, Harro Seelaar, Inez H. G. B. Ramakers, Frans R. J. Verhey, Aad van der Lugt, Jurgen A. H. R. Claassen, Geert Jan Biessels, Peter Paul De Deyn, Philip Scheltens, Wiesje M. van der Flier, John C. van Swieten, Yolande A. L. Pijnenburg, Sven J. van der Lee
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be genetically explained yet and it is likely that there are still FTD risk loci to be discovered. Common variants have been identified with genom
Externí odkaz:
https://doaj.org/article/c590880938b54bc184c9ea16e2a476f4
Autor:
Niccolò Tesi, Marc Hulsman, Sven J. van der Lee, Iris E. Jansen, Najada Stringa, Natasja M. van Schoor, Philip Scheltens, Wiesje M. van der Flier, Martijn Huisman, Marcel J. T. Reinders, Henne Holstege
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Human longevity is influenced by the genetic risk of age-related diseases. As Alzheimer’s disease (AD) represents a common condition at old age, an interplay between genetic factors affecting AD and longevity is expected. We explored this interplay
Externí odkaz:
https://doaj.org/article/68c9a6c9c02a4447b4ba4dd410d447da
Autor:
Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival perc
Externí odkaz:
https://doaj.org/article/43040ac329044c8a980e87b5849d94cd
Autor:
Jarith L. Ebenau, Sven J. van derLee, Marc Hulsman, Niccolò Tesi, Iris E. Jansen, Inge M.W. Verberk, Mardou vanLeeuwenstijn, Charlotte E. Teunissen, Frederik Barkhof, Niels D. Prins, Philip Scheltens, Henne Holstege, Bart N.M. vanBerckel, Wiesje M. van derFlier
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction We investigated relationships among genetic determinants of Alzheimer's disease (AD), amyloid/tau/neurodegenaration (ATN) biomarkers, and risk of dementia. Methods We studied cognitively normal individuals with subjective cognit
Externí odkaz:
https://doaj.org/article/f7b9d3ce60aa4f109863674dff7bb41b
Autor:
Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22613-2
Externí odkaz:
https://doaj.org/article/22274fdaa9da45edb97a7c76d79337dd
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 49, W603-W612. Oxford University Press
Nucleic acids research, 49(W1)
Tesi, N, van der Lee, S, Hulsman, M, Holstege, H & Reinders, M J T 2021, ' SnpXplorer: A web application to explore human SNP-associations and annotate SNP-sets ', Nucleic Acids Research, vol. 49, pp. W603-W612 . https://doi.org/10.1093/nar/gkab410
Nucleic Acids Research, 49, W603-W612. Oxford University Press
Nucleic acids research, 49(W1)
Tesi, N, van der Lee, S, Hulsman, M, Holstege, H & Reinders, M J T 2021, ' SnpXplorer: A web application to explore human SNP-associations and annotate SNP-sets ', Nucleic Acids Research, vol. 49, pp. W603-W612 . https://doi.org/10.1093/nar/gkab410
Genetic association studies are frequently used to study the genetic basis of numerous human phenotypes. However, the rapid interrogation of how well a certain genomic region associates across traits as well as the interpretation of genetic associati
Autor:
Martijn Huisman, Marcel J. T. Reinders, Sven J. van der Lee, Henne Holstege, Philip Scheltens, Wiesje M. van der Flier, Najada Stringa, Natasja M. van Schoor, Marc Hulsman, Niccolò Tesi, Iris E. Jansen
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences, 76(5), 750-759. Oxford University Press
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N M, Scheltens, P, van der Flier, W M, Huisman, M, Reinders, M J T & Holstege, H 2021, ' Polygenic risk score of longevity predicts longer survival across an age-continuum ', The Journals of Gerontology. Series A : Biological Sciences and Medical Sciences, vol. 76, no. 5, pp. 750-759 . https://doi.org/10.1093/gerona/glaa289
Journals of Gerontology-Series A Biological Sciences and Medical Sciences, 76(5)
The Journals of Gerontology. Series A : Biological Sciences and Medical Sciences, 76(5), 750-759. Oxford University Press
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N M, Scheltens, P, van der Flier, W M, Huisman, M, Reinders, M J T & Holstege, H 2021, ' Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 76, no. 5, pp. 750-759 . https://doi.org/10.1093/gerona/glaa289, https://doi.org/10.1093/gerona/glaa289
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N M, Scheltens, P, van der Flier, W M, Huisman, M, Reinders, M J T & Holstege, H 2021, ' Polygenic risk score of longevity predicts longer survival across an age-continuum ', The Journals of Gerontology. Series A : Biological Sciences and Medical Sciences, vol. 76, no. 5, pp. 750-759 . https://doi.org/10.1093/gerona/glaa289
Journals of Gerontology-Series A Biological Sciences and Medical Sciences, 76(5)
The Journals of Gerontology. Series A : Biological Sciences and Medical Sciences, 76(5), 750-759. Oxford University Press
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N M, Scheltens, P, van der Flier, W M, Huisman, M, Reinders, M J T & Holstege, H 2021, ' Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 76, no. 5, pp. 750-759 . https://doi.org/10.1093/gerona/glaa289, https://doi.org/10.1093/gerona/glaa289
Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a8125152d9f3b2a7cad2203c8d762f
https://research.vumc.nl/en/publications/0af7d75a-161c-473c-89d1-6bb0ba4cb2f3
https://research.vumc.nl/en/publications/0af7d75a-161c-473c-89d1-6bb0ba4cb2f3
Autor:
Marc Hulsman, Najada Stringa, Henne Holstege, Philip Scheltens, Natasja M. van Schoor, Sven J. van der Lee, Iris E. Jansen, Marcel J. T. Reinders, Niccolò Tesi, Wiesje M. van der Flier, Martijn Huisman, Hanne Meijers-Heijboer
Publikováno v:
European Journal of Human Genetics
European Journal of Human Genetics, 27(2), 244-253. Nature Publishing Group
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N, Meijers-Heijboer, H, Huisman, M, Scheltens, P, Reinders, M J T, van der Flier, W M & Holstege, H 2019, ' Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease ', European Journal of Human Genetics, vol. 27, no. 2, pp. 244-253 . https://doi.org/10.1038/s41431-018-0273-5
European journal of human genetics, 27(2), 244-253. Nature Publishing Group
European Journal of Human Genetics, 27(2)
European Journal of Human Genetics, 27(2), 244-253. Nature Publishing Group
Tesi, N, van der Lee, S J, Hulsman, M, Jansen, I E, Stringa, N, van Schoor, N, Meijers-Heijboer, H, Huisman, M, Scheltens, P, Reinders, M J T, van der Flier, W M & Holstege, H 2019, ' Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease ', European Journal of Human Genetics, vol. 27, no. 2, pp. 244-253 . https://doi.org/10.1038/s41431-018-0273-5
European journal of human genetics, 27(2), 244-253. Nature Publishing Group
European Journal of Human Genetics, 27(2)
The detection of genetic loci associated with Alzheimer’s disease (AD) requires large numbers of cases and controls because variant effect sizes are mostly small. We hypothesized that variant effect sizes should increase when individuals who repres
Autor:
Sarah Cubaynes, Joanne M. Murabito, Eric S. Orwoll, Iris E. Jansen, Joanna Collerton, Vilmundur Gudnason, Mikko Hurme, Paola Sebastiani, Carol Jagger, Carmen Martin-Ruiz, Douglas P. Kiel, Henne Holstege, Kenny Ye, Pilar Galan, Wolfgang Lieb, Diana van Heemst, Janina Dose, Wanlin Zheng, Ilkka Seppälä, Ashley van der Spek, Jessica D. Faul, Nir Barzilai, David R. Weir, James W. Vaupel, Wiesje M. van der Flier, Dan E. Arking, Terho Lehtimäki, Marja Jylhä, Thomas B. L. Kirkwood, Andrew Kingston, Marcel J. T. Reinders, Jean-François Deleuze, Cornelia M. van Duijn, Hélène Blanché, Anne B. Newman, Chao Nie, Elizabeth J. Becker, Daniel S. Evans, P. Eline Slagboom, Marianne Nygaard, Lene Christiansen, Jean Marie Robine, Junxia Min, Almut Nebel, Tamara B. Harris, Lenore J. Launer, Mary K. Wojczynski, Ellen A. Nohr, Alice M. Arnold, Olli T. Raitakari, Birgit Debrabant, Jerome I. Rotter, Thorkild I. A. Sørensen, André G. Uitterlinden, Steven R. Cummings, Kristin L. Ayers, Jennifer A. Smith, Joris Deelen, Yi Zeng, Chloé Sarnowski, Heather J. Cordell, Karen Davies, Kent D. Taylor, Mika Kähönen, Albert V. Smith, Najaf Amin, Rachel Duncan, Michael A. Province, Leo-Pekka Lyytikäinen, Kathryn L. Lunetta, Kaare Christensen, Sharon L.R. Kardia, Thomas T. Perls, Erin B. Ware, Martijn Huisman, Mary L. Biggs, Marian Beekman, Sven J. van der Lee, David Karasik, Niccolò Tesi, Xiaomin Liu, Gil Atzmon, Claudio Franceschi, Bruce M. Psaty
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the ag
Autor:
Najada Stringa, Henne Holstege, Martijn Huisman, P. Scheltens, van der Lee Sj, van Schoor Nm, Marc Hulsman, Niccolò Tesi, van der Flier Wm, Reinders Mjt, Iris E. Jansen
The genetics underlying human longevity is influenced by the genetic risk to develop -or escape- age-related diseases. As Alzheimer’s disease (AD) represents one of the most common conditions at old age, an interplay between genetic factors for AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee91d986976f9d05ab8cf6caa792ac0f
https://doi.org/10.1101/2021.02.02.21250991
https://doi.org/10.1101/2021.02.02.21250991