Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Nic Waddell"'
Autor:
Siddharth Sankar Singh, Shashi Bhushan Chauhan, Susanna SS Ng, Dillon Corvino, Fabian deLabastida Rivera, Jessica A Engel, Nic Waddell, Pamela Mukhopadhay, Rebecca L Johnston, Lambros T Koufariotis, Susanne Nylen, Om Prakash Singh, Christian R Engwerda, Rajiv Kumar, Shyam Sundar
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 6, Pp n/a-n/a (2022)
Abstract Objectives There is an urgent need to be able to identify individuals with asymptomatic Leishmania donovani infection, so their risk of progressing to VL and transmitting parasites can be managed. This study examined transcriptional markers
Externí odkaz:
https://doaj.org/article/c8386e62bb9941d5a08ca83178c44f0d
Autor:
Rajiv Kumar, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J. Faleiro, Chelsea L. Edwards, Teija C.M. Frame, Meru Sheel, Rebecca J. Austin, Steven W. Lane, Tobias Bald, Mark J. Smyth, Geoffrey.R. Hill, Shannon E. Best, Ashraful Haque, Dillon Corvino, Nic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R. Engwerda
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2512-2525.e9 (2020)
Summary: Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T ce
Externí odkaz:
https://doaj.org/article/e785a439bde64e73885e903f52fe0682
Autor:
Kelly Quek, Katia Nones, Ann-Marie Patch, J. Lynn Fink, Felicity Newell, Nicole Cloonan, David Miller, Muhammad Z. H. Fadlullah, Karin Kassahn, Angelika N. Christ, Timothy J. C. Bruxner, Suzanne Manning, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Anita Steptoe, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Qinying Xu, Peter Wilson, Andrew V. Biankin, John V. Pearson, Nic Waddell, Sean M. Grimmond
Publikováno v:
BioTechniques, Vol 57, Iss 1, Pp 31-38 (2014)
Somatic rearrangements, which are commonly found in human cancer genomes, contribute to the progression and maintenance of cancers. Conventionally, the verification of somatic rearrangements comprises many manual steps and Sanger sequencing. This is
Externí odkaz:
https://doaj.org/article/dd6f3fcf04a54456ae88b85267a1e519
Autor:
Darrell C Bessette, Erik Tilch, Tatjana Seidens, Michael C J Quinn, Adrian P Wiegmans, Wei Shi, Sibylle Cocciardi, Amy McCart-Reed, Jodi M Saunus, Peter T Simpson, Sean M Grimmond, Sunil R Lakhani, Kum Kum Khanna, Nic Waddell, Fares Al-Ejeh, Georgia Chenevix-Trench
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125232 (2015)
Basal-like and triple negative breast cancer (TNBC) share common molecular features, poor prognosis and a propensity for metastasis to the brain. Amplification of epidermal growth factor receptor (EGFR) occurs in ~50% of basal-like breast cancer, and
Externí odkaz:
https://doaj.org/article/1aeb5efb8fdc47a187350d3ae92f42ba
Autor:
Sarah Song, Katia Nones, David Miller, Ivon Harliwong, Karin S Kassahn, Mark Pinese, Marina Pajic, Anthony J Gill, Amber L Johns, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Qinying Xu, Felicity Newell, Mark J Cowley, Jianmin Wu, Peter Wilson, Lynn Fink, Andrew V Biankin, Nic Waddell, Sean M Grimmond, John V Pearson
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45835 (2012)
Tumour cellularity, the relative proportion of tumour and normal cells in a sample, affects the sensitivity of mutation detection, copy number analysis, cancer gene expression and methylation profiling. Tumour cellularity is traditionally estimated b
Externí odkaz:
https://doaj.org/article/0a1169d0232c46ce9e20460b4fa36033
Autor:
Logan C Walker, Bryony A Thompson, Nic Waddell, kConFab Investigators, Sean M Grimmond, Amanda B Spurdle
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000850 (2010)
A large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2. Laboratory-based methods that can distinguish between carriers of pathogenic mutations and non-
Externí odkaz:
https://doaj.org/article/c1e8b2981a1f4722b92fea2cef611d8b
Autor:
Nic Waddell, Anette Ten Haaf, Anna Marsh, Julie Johnson, Logan C Walker, kConfab Investigators, Milena Gongora, Melissa Brown, Piyush Grover, Mark Girolami, Sean Grimmond, Georgia Chenevix-Trench, Amanda B Spurdle
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000080 (2008)
The functional consequences of missense variants in disease genes are difficult to predict. We assessed if gene expression profiles could distinguish between BRCA1 or BRCA2 pathogenic truncating and missense mutation carriers and familial breast canc
Externí odkaz:
https://doaj.org/article/e56535396f4e411b95f0a7a2e40c20c6
Autor:
David D.L. Bowtell, Georgia Chenevix-Trench, Anna deFazio, Michael J. Birrer, Raghwa Sharma, Peter Russell, Nadia Traficante, Sian Fereday, Bianca Locandro, Lisa Simms, Nic Waddell, Richard Tothill, Anna V. Tinker, Joshy George, Jeremy M. Arnold, Michael S. Anglesio
Approximately, 10% to 15% of serous ovarian tumors fall into the category designated as tumors of low malignant potential (LMP). Like their invasive counterparts, LMP tumors may be associated with extraovarian disease, for example, in the peritoneal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03781d98b99c41ca8e5b1e997df72fcd
https://doi.org/10.1158/1541-7786.c.6541827.v1
https://doi.org/10.1158/1541-7786.c.6541827.v1
Autor:
David D.L. Bowtell, Georgia Chenevix-Trench, Anna deFazio, Michael J. Birrer, Raghwa Sharma, Peter Russell, Nadia Traficante, Sian Fereday, Bianca Locandro, Lisa Simms, Nic Waddell, Richard Tothill, Anna V. Tinker, Joshy George, Jeremy M. Arnold, Michael S. Anglesio
Supplementary Data from Mutation of ERBB2 Provides a Novel Alternative Mechanism for the Ubiquitous Activation of RAS-MAPK in Ovarian Serous Low Malignant Potential Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89759be531593a8709ce6793471abd0c
https://doi.org/10.1158/1541-7786.22517790.v1
https://doi.org/10.1158/1541-7786.22517790.v1
Autor:
Ashraful Haque, Shannon E. Best, Dillon Corvino, Fabian de Labastida Rivera, Rajiv Kumar, Marcela Montes de Oca, David B. Sacks, Meru Sheel, Chelsea L. Edwards, Pamela Mukhopadhay, Rebecca Austin, Teija C. M. Frame, Neetu Singh, Madhukar Rai, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Geoffrey R. Hill, Rebecca J. Faleiro, Steven W. Lane, Nic Waddell, Om Prakash Singh, Shyam Sundar, Jude E. Uzonna, Mark J. Smyth, Shashi Bhushan Chauhan, Tobias Bald, Susanne Nylén, Christian R. Engwerda, Lambross Koufariotis, Jaya Chakravarty
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2512-2525.e9 (2020)
Cell reports
Cell reports
SUMMARY Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bf3ffbda169ab00612b40ec142a440
http://www.sciencedirect.com/science/article/pii/S2211124720301339
http://www.sciencedirect.com/science/article/pii/S2211124720301339