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Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.

Autor: Leong IUS; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Cabrera CP; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Cipriani V; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom., Ross PJ; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Turner RM; Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.; GSK, Stevenage, Hertfordshire, United Kingdom., Stuckey A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Sanghvi S; Integrating Pharmacy & Medicines Optimisation Team, NHS North Central London Integrated Care System, UCLH NHS Foundation Trust, London., Pasko D; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Moutsianas L; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Odhams CA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Elgar GS; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Chan G; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Giess A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Walker S; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Foulger RE; SciBite Limited, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, UK., Williams EM; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Daugherty LC; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Rueda-Martin A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Rhodes DJ; BenevolentAI, London, United Kingdom., Niblock O; Cambridge Genomics Laboratory, United Kingdom., Pickard A; NHS England and NHS Improvement, London, United Kingdom., Marks L; NHS England and NHS Improvement, London, United Kingdom., Leigh SEA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Welland MJ; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Bleda M; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Snow C; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Deans Z; NHS England and NHS Improvement, London, United Kingdom.; GenQA, Laboratory Medicine, NHS Lothian NINE, Edinburgh, United Kingdom., Murugaesu N; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom.; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Scott RH; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Barnes MR; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Brown MA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom.; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Rendon A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Hill S; NHS England and NHS Improvement, London, United Kingdom., Sosinsky A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Caulfield MJ; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; Faculty of Medicine and Dentistry, VP Health Office, Queen Mary University of London, London, United Kingdom., McDonagh EM; Open Targets, Wellcome Genome Campus, Hinxton, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Oct 31, pp. JCO2302761. Date of Electronic Publication: 2024 Oct 31.