Zobrazeno 1 - 10
of 528
pro vyhledávání: '"Nibaldo C, Inestrosa"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Mitochondria are key organelles for the optimal function of the cell. Among their many functions, they maintain protein homeostasis through their own proteostatic machinery, which involves proteases and chaperones that regulate protein import and fol
Externí odkaz:
https://doaj.org/article/5bddec5f0af64b659cb071825db3707d
Autor:
Carolina A. Oliva, Matías Lira, Claudia Jara, Alejandra Catenaccio, Trinidad A. Mariqueo, Carolina B. Lindsay, Francisco Bozinovic, Grisel Cavieres, Nibaldo C. Inestrosa, Cheril Tapia-Rojas, Daniela S. Rivera
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Social interactions have a significant impact on health in humans and animal models. Social isolation initiates a cascade of stress-related physiological disorders and stands as a significant risk factor for a wide spectrum of morbidity and mortality
Externí odkaz:
https://doaj.org/article/14d0878ab9b747d19ede0b7e1c46b3ee
Autor:
Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G. William Wong, Nibaldo C. Inestrosa
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer’s disease (AD). However, the underlying mecha
Externí odkaz:
https://doaj.org/article/6a6e6e8a260442fa857ce0bab68eb2d1
Autor:
Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M. Zolezzi, Nibaldo C. Inestrosa
Publikováno v:
Biological Research, Vol 55, Iss 1, Pp 1-18 (2022)
Abstract Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to activate astrocytes and micro
Externí odkaz:
https://doaj.org/article/424aeb59d19f4d7bbaa09b827fd93235
Autor:
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2007 (2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged
Externí odkaz:
https://doaj.org/article/52442aebd7684326868078bfe18e45e8
Autor:
Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio, Rodrigo Del Rio
Publikováno v:
Biological Research, Vol 55, Iss 1, Pp 1-8 (2022)
Externí odkaz:
https://doaj.org/article/a57eda3a35d44a24bacef20ed2eb82b1
Autor:
Francisca J. Allendes, Hugo S. Díaz, Fernando C. Ortiz, Noah J. Marcus, Rodrigo Quintanilla, Nibaldo C. Inestrosa, Rodrigo Del Rio
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
A significant percentage of COVID-19 survivors develop long-lasting cardiovascular sequelae linked to autonomic nervous system dysfunction, including fatigue, arrhythmias, and hypertension. This post-COVID-19 cardiovascular syndrome is one facet of
Externí odkaz:
https://doaj.org/article/066c8e0a3d3149bd91436b98a34f76b1
Autor:
Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio, Rodrigo Del Rio
Publikováno v:
Biological Research, Vol 54, Iss 1, Pp 1-14 (2021)
Abstract Background Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activ
Externí odkaz:
https://doaj.org/article/1c51032886d943c3bbe20d56af62ebfd
Autor:
Sebastian B. Arredondo, Daniel T. Reyes, Andrea Herrera-Soto, Muriel D. Mardones, Nibaldo C. Inestrosa, Lorena Varela-Nallar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate, induces
Externí odkaz:
https://doaj.org/article/ca4b966c21c9405888f78dead9baf1c9
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defined as Wnt/β-catenin-
Externí odkaz:
https://doaj.org/article/69f4185f972a4ebcaf08cb92e7aec51e