Glycomic and Glycoproteomic Analysis of Serum from Patients with Stomach Cancer Reveals Potential Markers Arising from Host Defense Response Mechanisms

Autor: Jennifer C. Byrne, Herve Boissin, Caitriona Scaife, Pauline M. Rudd, Jonathan Bones, Anca Nastase, Niaobh O'Donoghue, Ciara A. McManus

Publikováno v: Journal of Proteome Research. 10:1246-1265

Despite the reduced incidence of gastric cancer in the developed world, a diagnosis of stomach carcinoma still carries a poor prognosis due to the asymptomatic nature of the disease in the early stages, subsequent advanced stage diagnosis, and a low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ab695cad2dc3006cc411ac31f5572f
https://doi.org/10.1021/pr101036b

CyDye Immunoblotting for Proteomics: Co-detection of specific immunoreactive and total protein profiles

Autor: Michael J. Dunn, Ciara A. McManus, Stephen R. Pennington, Pamela Donoghue, Niaobh O'Donoghue

Publikováno v: Proteomics

The development of ECL-Plex CyDye-conjugated secondary antibodies allows the advancement of conventional Western blotting, opening up possibilities for highly sensitive and quantitative protein confirmation and identification. We report a novel prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fcd6061d1f27724b0fbef7cb763fb6
https://doi.org/10.1002/pmic.200600139

Bacitracin reveals a role for multiple thiol isomerases in platelet function

Autor: Niamh Moran, Aoife Kiernan, Aisling Robinson, Niaobh O'Donoghue, Sarah O'Neill

Publikováno v: British Journal of Haematology. 132:339-348

The platelet-specific integrin alphaIIb beta3 has endogenous thiol isomerase activity associated with the CXXC motifs within the beta subunit. Using a highly purified form of bacitracin, a thiol isomerase inhibitor, we now provide further evidence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2db224ed44733f771a86e31b81fc07a5
https://doi.org/10.1111/j.1365-2141.2005.05878.x

Structural characterisation of the N-glycan moiety of the barnacle settlement-inducing protein complex (SIPC)

Autor: Jon Marles-Wright, Richard J. Lewis, Niaobh O'Donoghue, Anthony S. Clare, Gary S. Caldwell, Jodie L. Abrahams, J. Robin Harris, Jonathan Bones, Helen E. Pagett, Pauline M. Rudd

Publikováno v: Pagett, H E, Abrahams, J L, Bones, J, O'Donoghue, N, Marles-Wright, J, Lewis, R J, Harris, J R, Caldwell, G S, Rudd, P M & Clare, A S 2012, ' Structural characterisation of the N-glycan moiety of the barnacle settlement-inducing protein complex (SIPC) ', Journal of Experimental Biology, vol. 215, no. Pt 7, pp. 1192-8 . https://doi.org/10.1242/jeb.063503

SUMMARYMany barnacle species are gregarious and their cypris larvae display a remarkable ability to explore surfaces before committing to permanent attachment. The chemical cue to gregarious settlement behaviour – the settlement-inducing protein co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075ce601ff4724582194458865c48c23
https://hdl.handle.net/20.500.11820/d1b716e4-24d9-4365-bfbd-0050766b367c

Glycan characterization of PSA 2-DE subforms from serum and seminal plasma

Autor: Niaobh O'Donoghue, Pauline M. Rudd, Rafael de Llorens, Ariadna Sarrats, Josep Comet, Rosa Peracaula, Radka Saldova

Publikováno v: © OMICS A Journal of Integrative Biology, 2010, vol. 14, núm. 4, p. 465-474
Articles publicats (D-B)
DUGiDocs – Universitat de Girona
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Recercat. Dipósit de la Recerca de Catalunya

Prostate-specific antigen (PSA) two-dimensional electrophoresis (2-DE) subforms (F1-F5) have been described to be altered in prostate cancer (PCa) compared to benign prostatic hyperplasia (BPH). To understand their molecular differences, characteriza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9518d5b2ff3439109606f8ff86e3ce5
https://pubmed.ncbi.nlm.nih.gov/20726802