Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Niannian Xue"'
Autor:
Niannian Xue, Xu Liu, Dan Zhang, Youming Wu, Yi Zhong, Jinxin Wang, Wenjing Fan, Haixia Jiang, Biyun Zhu, Xiyu Ge, Rachel V. L. Gonzalez, Liang Chen, Shun Zhang, Peilu She, Zhilin Zhong, Jianjian Sun, Xi Chen, Liren Wang, Zhimin Gu, Ping Zhu, Mingyao Liu, Dali Li, Tao P. Zhong, Xiaohui Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
There is a low efficiency of A-to-G base conversion in at specific positions using base editors. Here the authors fuse ABE8e with the Rad51 DNA-binding domain to generate a hyperactive ABE allowing improved A-to-G editing efficiency at the region pro
Externí odkaz:
https://doaj.org/article/ca3296a02cb34bdaa44b40fa174ab29c
Autor:
Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhixin Lei, Yuting Chen, Yuting Guan, Stefan Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, Chengqi Yi, Mingyao Liu, Dali Li
Publikováno v:
Nature Biotechnology. 41:663-672
Cytosine base editors (CBEs) efficiently generate precise C·G-to-T·A base conversions, but the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (AID/APOBEC) protein family deaminase component ind
Autor:
Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong, Xiaohui Zhang, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Hongyi Gao, Liping Zhong, Meizhen Liu, Mingyao Liu, Yiyun Cheng, Chengqi Yi, Liren Wang, Yongxiang Zhao, Gaojie Song, Dali Li
Publikováno v:
Nature Chemical Biology. 19:101-110
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns. Through structure-guided engineering, we found ABE8e with an N108Q mutation reduce
Autor:
Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong, Xiaohui Zhang, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Meizhen Liu, Mingyao Liu, Yiyun Cheng, Chengqi Yi, Gaojie Song, Liren Wang, Dali Li
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise the concerns of safety issues. Through structure-guided engineering, we found ABE8e with an N108Q m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4dd15a8163cf61d2da15964b4b0aeaf
https://doi.org/10.1101/2022.08.12.503700
https://doi.org/10.1101/2022.08.12.503700