Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Nianhang, Chen"'
Publikováno v:
Molecules, Vol 29, Iss 8, p 1867 (2024)
Natural products (NPs) have diverse biological activity and significant medicinal value. The structural diversity of NPs is the mainstay of drug discovery. Expanding the chemical space of NPs is an urgent need. Inspired by the concept of fragment-ass
Externí odkaz:
https://doaj.org/article/933ffc73df2b4f86a21ff4dbf65310ff
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 815-827 (2022)
Abstract Early prognosis of clinical efficacy is an urgent need for oncology drug development. Herein, we systemically examined the quantitative approach of tumor growth inhibition (TGI) and survival modeling in the space of relapsed and refractory m
Externí odkaz:
https://doaj.org/article/f724d2c040e14237bef0378fc971f6a4
Autor:
Nianhang Chen, Nastya Kassir, Abderrahmane Laadem, Stephen E. Maxwell, Priya Sriraman, Ana Carolina Giuseppi, Steve Ritland, Peter G. Linde, Balasubrahmanyam Budda, Joseph G. Reynolds, Simon Zhou, Maria Palmisano
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 395-404 (2020)
Luspatercept is a recombinant fusion protein that enhances late‐stage erythroid maturation. This report describes the population pharmacokinetics and exposure–response relationship of luspatercept in 260 patients with anemia due to myelodysplasti
Externí odkaz:
https://doaj.org/article/b71c1d3971b14218bd2a4fcb5ebcb47a
Publikováno v:
PeerJ, Vol 9, p e10884 (2021)
Applying the knowledge that methyltransferases and demethylases can modify adjacent cytosine-phosphorothioate-guanine (CpG) sites in the same DNA strand, we found that combining multiple CpGs into a single block may improve cancer diagnosis. However,
Externí odkaz:
https://doaj.org/article/b23c7bd7ec92470c934b68bb3bf2be69
Publikováno v:
Physical Chemistry Chemical Physics. 25:8090-8102
Molecular dynamic simulations identifying mechanism of holoenzyme formation by O-GlcNAc transferase and active p38α.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e221834992a63f95a775488a8dd588
https://doi.org/10.1039/d2cp05968a
https://doi.org/10.1039/d2cp05968a
Autor:
James L. Rubenstein, Huimin Geng, Eleanor J. Fraser, Paul Formaker, Lingjing Chen, Jigyasa Sharma, Phoebe Killea, Kaylee Choi, Jenny Ventura, John Kurhanewicz, Clifford Lowell, Jimmy Hwang, Patrick Treseler, Penny K. Sneed, Jing Li, Xiaomin Wang, Nianhang Chen, Jon Gangoiti, Pamela N. Munster, Bertil Damato
Publikováno v:
Blood Advances, Vol 2, Iss 13, Pp 1595-1607 (2018)
Abstract: There is an unmet need for effective biological therapies for relapsed central nervous system (CNS) lymphoma. Lenalidomide is active in activated B-cell type diffuse large B-cell lymphoma and rituximab is effective in CNS lymphoma. These ob
Externí odkaz:
https://doaj.org/article/d45dc5be976041088c86e35ec3632a1e
Publikováno v:
Database. 2023
Terpenoids and their derivatives are collectively known as the terpenome and are the largest class of natural products, whose biosynthesis refers to various kinds of enzymes. To date, there is no terpenome-related enzyme database, which is a desire f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2908e70eb41d4e4361a90e6696e6466f
https://doi.org/10.1093/database/baad020
https://doi.org/10.1093/database/baad020
Publikováno v:
Natural Product Reports.
Glycosylation is one of the most important modifications of natural products. This highlight gives the glycosylation preference of the natural products in the DNP database with the aspect of biological source and structural class.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9891912f849bb783c3bcbd379421e00f
https://doi.org/10.1039/d2np00089j
https://doi.org/10.1039/d2np00089j
Publikováno v:
Molecules, Vol 24, Iss 21, p 4003 (2019)
There is a continued need to develop new selective human monoamine oxidase (hMAO) inhibitors that could be beneficial for the treatment of neurological diseases. However, hMAOs are closely related with high sequence identity and structural similarity
Externí odkaz:
https://doaj.org/article/8bdd46b3fe5f482abf65714d39b11e8c
Autor:
Simon Zhou, Priya Sriraman, Ana Carolina Giuseppi, Stephen E. Maxwell, Balasubrahmanyam Budda, Peter G. Linde, Steve Ritland, Maria Palmisano, Joseph G. Reynolds, Nianhang Chen, Abderrahmane Laadem, Nastya Kassir
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 395-404 (2020)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Luspatercept is a recombinant fusion protein that enhances late-stage erythroid maturation. This report describes the population pharmacokinetics and exposure-response relationship of luspatercept in 260 patients with anemia due to myelodysplastic sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902d129e84b79a9e9ae185d6825800f1
https://doaj.org/article/b71c1d3971b14218bd2a4fcb5ebcb47a
https://doaj.org/article/b71c1d3971b14218bd2a4fcb5ebcb47a