Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Niandong Qian"'
Autor:
Hao Tian, Tao Jiang, Kai Yang, Ruonan Ning, Tianqi Wang, Qi Zhou, Niandong Qian, Ping Huang, Lei Guo, Min Jiang, Xiaobing Xi, Xing Xu, Lianfu Deng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osteoporosis (OP) is defined as low bone mineral density which features over activated osteoclasts (OCs) and bone resorption. Targeting excessive OCs activity is thought to be an effective therapeutic approach for OP treatment. α-asarone (ASA), a co
Externí odkaz:
https://doaj.org/article/66ae35d4938649f7bac26dac0882d097
Autor:
Kaizhe Chen, Qi Zhou, Hui Kang, Yufei Yan, Niandong Qian, Changwei Li, Fei Wang, Kai Yang, Lianfu Deng, Jin Qi
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Tissue engineering with 3D scaffold is a simple and effective method for bone healing after large-scale bone loss. So far, bone marrow-derived mesenchymal stem cells (BMSCs) are mostly used in the treatment of bone healing in animal models due to the
Externí odkaz:
https://doaj.org/article/4b1a4fa5702d41a5b43d22d69f3356e7
Publikováno v:
Designed Monomers and Polymers, Vol 20, Iss 1, Pp 351-362 (2017)
OIC-A006 (BMPs osteogenesis compounds), can stimulate bone marrow mesenchymal stem cells ALP, OPN, OC, Cbfal expression. To stimulate new bone formation in the body. We postulate different amounts of drug microspheres on the PLGA/β-CPT scaffold can
Externí odkaz:
https://doaj.org/article/516c84c1e2294392980b33e0ec982c08
Autor:
Tingyu Wang, Han Qiao, Zanjing Zhai, Jun Zhang, Jinwen Tu, Xinyi Zheng, Niandong Qian, Hong Zhou, Eryi Lu, Tingting Tang
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Objective: Plumbago zeylanica L. (with plumbagin as its active ingredients) has been used for centuries to treat conditions such as joint swelling, fractures, and bacterial infections, suggesting that it possesses anti-inflammatory and immunosuppress
Externí odkaz:
https://doaj.org/article/e6e8587cd180497da90d026a932da98e
Autor:
Niandong Qian, Jin Qi, Qi Zhou, Xing Xu, Hanbing Zhou, Lianfu Deng, Min Jiang, Kai Yang, Tianqi Wang, Tao Jiang, Ping Huang, Xueming Yan, Lei Guo, Zhuochao Liu, Xingkai Zhang, Bo Chen
Publikováno v:
The FASEB Journal. 33:9828-9841
Identification of anti-osteoclastogenic agents is important for the treatment of bone loss diseases that feature excessive osteoclast (OC) activity and bone resorption. Tranylcypromine (TCP), an irreversible inhibitor of monoamine oxidase (MAO), has
Autor:
Jianrong Xu, Hanbing Zhou, Bo Chen, Xing Xu, Tianqi Wang, Jin Qi, Kai Yang, Qi Zhou, Xueming Yan, Niandong Qian, Chunhao Yang, Lianfu Deng, Tao Jiang, Lei Peng, Min Jiang
Publikováno v:
Journal of Medicinal Chemistry. 62:5370-5381
Targeting RANKL/RANK offers the possibility of developing novel therapeutic approaches to treat bone metabolic diseases. Multiple efforts have been made to inhibit RANKL. For example, marketed monoclonal antibody drug Denosumab could inhibit the matu
Autor:
Changjun Guo, Niandong Qian, Jin Qi, Xueming Yan, Bo Chen, Changwei Li, Kai Yang, Yufei Yan, Hanbing Zhou, Qi Zhou, Yifan Cheng, Fei Wang, Dongming Yan, Xiangyang Xu, Lianfu Deng, Min Jiang
Publikováno v:
Bone. 120:156-165
Deferoxamine (DFO) possesses a good chelating capability and is therefore used for the clinical treatment of ion deposition diseases. Increasing evidence shows that DFO can inhibit the activity of proline hydroxylase (PHD) by chelating iron, resultin
Autor:
Haokai Shen, Changjun Guo, Ruoyu Cheng, Kaizhe Chen, Jin Qi, Niandong Qian, Yu Shrike Zhang, Yufei Yan, Hao Chen, Niklas Sandler, Kai Yang, Lianfu Deng, Wenguo Cui, Hongbo Zhang
Publikováno v:
Biomaterials. :97-110
3D printed scaffolds hold promising perspective for bone tissue regeneration. Inspired by process of bone development stage, 3D printed scaffolds with rapid internal vascularization ability and robust osteoinduction bioactivity will be an ideal bone
Autor:
Jin Qi, Qi Zhou, Lianfu Deng, Bo Chen, Kai Yang, Zhuochao Liu, Chunhao Yang, Yufei Yan, Xiaobing Xi, Min Jiang, Xing Xu, Tianqi Wang, Xueming Yan, Hanbing Zhou, Niandong Qian
Publikováno v:
Journal of Bone and Mineral Research. 34:361-374
Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target-directed agents that inhibit excessi
Autor:
Tao Ding, Niandong Qian, Lei Guo, Kaizhe Chen, Fangqiong Hu, Bo Chen, Qi Zhou, Lianfu Deng, Xing Xu, Bin Li, Tianwen Ye, Ping Huang
Publikováno v:
Journal of Cellular and Molecular Medicine
Osteoarthritis (OA) is one of the most frequent chronic joint diseases with the increasing life expectancy. The main characteristics of the disease are loss of articular cartilage, subchondral bone sclerosis and synovium inflammation. Physical measur