Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nianchun Ma"'
Publikováno v:
Ghosh, AK; Ma, N; Effenberger, KA; & Jurica, MS. (2014). Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity. Organic Letters, 16(11), 3154-3157. doi: 10.1021/ol501345d. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/68p4h3x7
Organic Letters
Organic letters, vol 16, iss 11
Organic Letters
Organic letters, vol 16, iss 11
An enantioselective total synthesis of GEX1Q1 has been accomplished in a convergent manner. The C-5 asymmetric center has now been assigned through synthesis. GEX1Q1 displayed slightly better spliceosome inhibitory activity over its C-5 epimer. The s
Autor:
Emilio L. Cárdenas, Nianchun Ma, Arun K. Ghosh, Melissa S. Jurica, Kerstin A. Effenberger, Kai Lv
Publikováno v:
Organic & biomolecular chemistry, vol 14, iss 23
Ghosh, AK; Lv, K; Ma, N; Cardenas, EL; Effenberger, KA; & Jurica, MS. (2016). Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene. ORGANIC & BIOMOLECULAR CHEMISTRY, 14(23), 5263-5271. doi: 10.1039/c6ob00725b. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/5549r8bw
Ghosh, AK; Lv, K; Ma, N; Cardenas, EL; Effenberger, KA; & Jurica, MS. (2016). Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene. ORGANIC & BIOMOLECULAR CHEMISTRY, 14(23), 5263-5271. doi: 10.1039/c6ob00725b. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/5549r8bw
Herboxidiene is a potent inhibitor of spliceosomes. It exhibits excellent anticancer activity against multiple human cancer cell lines. Herein, we describe an enantioselective synthesis of a desmethyl derivative and the corresponding carba-derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a56230727890db00f04d940c46563e
https://escholarship.org/uc/item/5549r8bw
https://escholarship.org/uc/item/5549r8bw
Publikováno v:
European Journal of Medicinal Chemistry. 43:1781-1784
Homoclausenamide was synthesized for the first time, and the intramolecular cyclization study of N-methyl-3-phenyl-N-(2-(E)-phenylethenyl)-trans(cis)-oxiranecarboxamide well demonstrated how the stereochemistry affects the cyclization paths.
Publikováno v:
European Journal of Medicinal Chemistry. 41:397-400
Anisodine (l-6,7-epoxy-3-tropyl-alpha-hydroxytropate), which was isolated from the medicinal plant Scopolia tanguticus Maxim, was the first efficiently prepared using 6-beta-acetyltropine as the starting material via a key step of the Sharpless asymm
Autor:
Zuosheng Liu, Jieping Zhu, Nianchun Ma, Michèle Bois-Choussy, and Adriano Malabarba, Yanxing Jia
Publikováno v:
The Journal of Organic Chemistry. 70:2847-2850
[reaction: see text] Synthesis of enantiomerically pure beta-amino-alpha-hydroxy esters (1, 2) and beta-amino-alpha-azido ester (3) using Sharpless AA as a key step is described. A hitherto unreported side reaction, the oxidation of the beta-hydroxy-
Autor:
Matthew Adams, Arun K. Ghosh, David D. Anderson, Nianchun Ma, Beth E. Prichard, Walter M. Bray, Kerstin A. Effenberger, Melissa S. Jurica
Publikováno v:
The Journal of biological chemistry, vol 289, iss 4
Effenberger, KA; Anderson, DD; Bray, WM; Prichard, BE; Ma, N; Adams, MS; et al.(2014). Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide b and its analogs. Journal of Biological Chemistry, 289(4), 1938-1947. doi: 10.1074/jbc.M113.515536. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/44z1p4j7
Effenberger, KA; Anderson, DD; Bray, WM; Prichard, BE; Ma, N; Adams, MS; et al.(2014). Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide b and its analogs. Journal of Biological Chemistry, 289(4), 1938-1947. doi: 10.1074/jbc.M113.515536. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/44z1p4j7
Pladienolide B (PB) is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. There is considerable interest in the compound as a potential chemotherapeutic, as well as a tool to study SF3B1 function in splicing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee53df6b27a69f60a8602c2a92e38e
https://escholarship.org/uc/item/44z1p4j7
https://escholarship.org/uc/item/44z1p4j7
Publikováno v:
Journal of Heterocyclic Chemistry. 45:785-787
Under Lewis acid condition, N-methyl-3-phenyl-N-(2-(Z)-phenylethenyl)-cis-oxiranecarboxamide undergoes elegant double cyclizations to give interesting products.
Publikováno v:
International journal of pharmaceutics. 427(1)
Short interfering RNA (siRNA) drugs have entered clinical trials in various disease areas. However, systemic use of siRNA drugs faces a challenge of tissue in-specificity and membrane impenetrability. In this study, we hypothesized that the combined
Publikováno v:
ChemInform. 33
A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields
Autor:
Zongyou Chen, Gang Zhao, Nianchun Ma, Okada Keisaku, Loren A. Perelman, Jian Liu, Padmanabh Chivukula, Lei Yu, Changxing Liu, David Gough
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 140(3)
Background Targeting of a specific subset of cells is mandatory for the successful application of siRNA mediated silencing in anticancer therapy. A recent theory suggests that colon cancer is sustained by a small subpopulation of cells, termed cancer