Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Niamh McGivern"'
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesio
Externí odkaz:
https://doaj.org/article/83349dab846e4f55a388ec199c877673
Autor:
Alex von Kriegsheim, Linda Kogerman, Bryan Serrels, Niamh McGivern, Alexander Loftus, Valerie G. Brunton, Billie Georgina Cooper Griffith, Emma S. Koeleman, Graeme R. Grimes, Ana Herrero, John C. Dawson, Jayne Culley, Adam Byron, Margaret C. Frame
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eeb54127bc4b815039464d35ac0fe22
https://doi.org/10.1101/2021.08.31.458428
https://doi.org/10.1101/2021.08.31.458428
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Byron, A, Griffith, B G C, Herrero, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, Kriegsheim, A V, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications, vol. 13, no. 1, 3053 . https://doi.org/10.1038/s41467-022-30556-5
Byron, A, Griffith, B, Herrero Mier, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, von Kriegsheim, A, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications . https://doi.org/10.1038/s41467-022-30556-5
Byron, A, Griffith, B, Herrero Mier, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, von Kriegsheim, A, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications . https://doi.org/10.1038/s41467-022-30556-5
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localis
Autor:
Alan Serrels, Stephen M. Anderton, Adam Byron, Alex von Kreigsheim, Marta Canel, Bryan Serrels, Niamh McGivern, Niall Quinn, David Taggart, Henry J. McSorley, Sarah C. Johnson, Margaret C. Frame
Publikováno v:
Serrels, B, McGivern, N, Canel, M, Byron, A, Johnson, S C, McSorley, H J, Quinn, N, Taggart, D, Von Kriegsheim, A, Anderton, S M, Serrels, A & Frame, M C 2017, ' IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks ', Science Signaling, vol. 10, no. 508, eaan8355 . https://doi.org/10.1126/scisignal.aan8355
Focal adhesion kinase (FAK) mediates tumor cell–intrinsic behaviors that promote tumor growth and metastasis. We previously showed that FAK also induces the expression of inflammatory genes that inhibit antitumor immunity in the microenvironment. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc27a51cf8bec56efc183656c499897
https://hdl.handle.net/20.500.11820/d8d1a438-f833-49f4-a123-f9ebc552b330
https://hdl.handle.net/20.500.11820/d8d1a438-f833-49f4-a123-f9ebc552b330
Autor:
Paul B. Mullan, Niamh McGivern, Aya El-Helali, Iain A. McNeish, Nuala McCabe, Richard D. Kennedy, D. Paul Harkin
Publikováno v:
Oncotarget
McGivern, N, El-Helali, A, Mullan, P, McNeish, I A, Paul Harkin, D, Kennedy, R D & McCabe, N 2018, ' Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer ', Oncotarget, vol. 9, no. 4, pp. 4722-4736 . https://doi.org/10.18632/oncotarget.23524
McGivern, N, El-Helali, A, Mullan, P, McNeish, I A, Paul Harkin, D, Kennedy, R D & McCabe, N 2018, ' Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer ', Oncotarget, vol. 9, no. 4, pp. 4722-4736 . https://doi.org/10.18632/oncotarget.23524
SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease. The SAPPROC trial investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47c5799ec8627ef39f87d03f32049b
http://hdl.handle.net/10044/1/56989
http://hdl.handle.net/10044/1/56989
Publikováno v:
Cancer Research. 79:3163-3163
Introduction: WEE1 kinase is a key component in maintaining the G2/M cell cycle checkpoint for pre-mitotic DNA repair, and is overexpressed in several cancer types. Novel therapeutics are currently being developed to target WEE1 kinase in cancer, how
Autor:
Naomi Dickson, Caolan Harkin, Laura A. Knight, Reinhold J. Medina, Aya El Helali, Caroline O. Michie, Jacqueline James, Lara Dura Perez, Stephen McQuaid, Christopher Steele, Alan W. Stitt, Nuala McCabe, Richard H. Wilson, Christina L. O'Neill, Niamh McGivern, Richard D. Kennedy, Denis Paul Harkin, Andrena McCavigan, W. Glenn McCluggage, Charlie Gourley
Publikováno v:
Cancer Research. 78:7-7
Introduction: 40-45% of patients with High Grade Serous Ovarian Cancer (HGSOC) will eventually relapse with platinum resistant disease. Tothill et al and TCGA are two independent gene expression datasets which have demonstrated the presence of a mese
Autor:
Alistair R.W. Williams, Andrena McCavigan, W. Glenn McCluggage, Niamh McGivern, Bethanie Price, Laura Hill, Richard D. Kennedy, Nuala McCabe, Michael Churchman, Katherine E. Keating, Caroline O. Michie, Timothy Davison, Denis Paul Harkin, Eamonn J. O'Brien, Aya El-Helai, Charlie Gourley, Aya El-Helali
Publikováno v:
Clinical Cancer Research. 23:MIP-055
BACKGROUND: We previously defined 3 molecular subgroups of High Grade Serous Ovarian Cancer (HGSOC), using gene expression data from 265 FFPE samples obtained from treatment naive patients, who received platinum based treatment following surgical res
Autor:
Glenn McCluggage, Nuala McCabe, Alistair R.W. Williams, Niamh McGivern, Caroline O. Michie, Laura Hill, Andrena McGavigan, Michael Churchman, Charlie Gourley, Richard D. Kennedy, Karen Keating, Eamonn J. O'Brien, Denis Paul Harkin, Timothy Davison
Publikováno v:
Cancer Research. 76:453-453
Introduction We have previously defined 3 molecular subgroups of High grade serous ovarian cancer (HGSOC), ‘Angio’, ‘Immune’ and ‘Angio_immune’ subgroups using gene expression data from 265 FFPE HGSOC samples obtained from treatment naive