Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Niamh M O'Boyle"'
Autor:
Lorena Ndreu, Josefine Carlsson, David J. Ponting, Ida B. Niklasson, E. Johanna L. Stéen, Lukas McHugh, Niamh M. O’Boyle, Kristina Luthman, Ann-Therese Karlberg, Isabella Karlsson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
BackgroundCinnamic alcohol is a natural compound, widely used in fragrances, which can cause allergic contact dermatitis. Cinnamic alcohol lacks intrinsic reactivity and autoxidation or metabolic activation is necessary for it to act as a sensitizer.
Externí odkaz:
https://doaj.org/article/3a70b102db8b43ccb2651c13464648e5
Autor:
James P. McKeown, Andrew J. Byrne, Sandra A. Bright, Clara E. Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M. McElligott, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1034 (2024)
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lym
Externí odkaz:
https://doaj.org/article/ec8f4b69512c421787aea349de4351eb
Autor:
Eavan C. McLoughlin, Dr. John E. O'Brien, Dr. Cristina Trujillo, Prof. Mary J. Meegan, Prof. Niamh M. O'Boyle
Publikováno v:
ChemistryOpen, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Trans‐β‐lactam isomers have garnered much attention as anti‐cancer microtubule targeting agents. Currently available synthetic methods are available for the preparation of enantiopure β‐lactams and favour isomeric cis/trans β‐la
Externí odkaz:
https://doaj.org/article/19958ee7f0264becb96843468f6b8e7b
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Autor:
Shu Wang, Azizah M. Malebari, Thomas F. Greene, Shubhangi Kandwal, Darren Fayne, Seema M. Nathwani, Daniela M. Zisterer, Brendan Twamley, Niamh M. O’Boyle, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1000 (2023)
A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene
Externí odkaz:
https://doaj.org/article/a88c634232124ff8893931a453eafe31
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Lipids are an important constituent of skin and are known to be modified in many skin diseases including psoriasis and atopic dermatitis. The direct effects of common metallic contact allergens on the lipid composition of skin has never been investig
Externí odkaz:
https://doaj.org/article/86d83501038448e9810432348d50bdf2
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 8, Pp 1187-1194 (2020)
A series of related substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones have been characterized: 3-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C25H24FNO5 (1), 3-(furan-2-yl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxy
Externí odkaz:
https://doaj.org/article/2bae3bc2b3bc400abee1abbb0cf21ac1
Autor:
Niamh M. O’Boyle, Jean-Jacques Helesbeux, Mary J. Meegan, Astrid Sasse, Elizabeth O’Shaughnessy, Alina Qaisar, Aoife Clancy, Florence McCarthy, Pascal Marchand
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 432 (2023)
The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held their 30th annual conference in August 2022 in Trinity College Dublin, Ireland. There were 9 keynote presentations, 10 early career researcher presentations and 41 poster
Externí odkaz:
https://doaj.org/article/2ee297a77f5e499aa47fe752cf8860d2
Autor:
Azizah M. Malebari, Gabriela Duffy Morales, Brendan Twamley, Darren Fayne, Mohemmed Faraz Khan, Eavan C. McLoughlin, Niamh M. O’Boyle, Daniela M. Zisterer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1044 (2022)
The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluo
Externí odkaz:
https://doaj.org/article/ce1244d0e8b94117b595145343d4558c
Autor:
Mary J. Meegan, Niamh M. O’Boyle
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 479 (2022)
This Special Issue of Pharmaceuticals is devoted to significant advances achieved in the field of Anticancer Drugs in 2021 [...]
Externí odkaz:
https://doaj.org/article/00e6ee57641b4a2fa6251f1c9c801f73