Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Niamh M Keane"'
Autor:
Eric Alves, Marwah Al-Kaabi, Niamh M Keane, Shay Leary, Coral-Ann M Almeida, Pooja Deshpande, Jennifer Currenti, Abha Chopra, Rita Smith, Alison Castley, Simon Mallal, Spyros A Kalams, Silvana Gaudieri, Mina John
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010965 (2022)
Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the individual and population level. To date, there has been limited exploration of the impact of
Externí odkaz:
https://doaj.org/article/5b3936e98d094b46928ee18e598394bf
Autor:
Andrew Lucas, Michaela Lucas, Anette Strhyn, Niamh M Keane, Elizabeth McKinnon, Rebecca Pavlos, Ellen M Moran, Viola Meyer-Pannwitt, Silvana Gaudieri, Lloyd D'Orsogna, Spyros Kalams, David A Ostrov, Søren Buus, Bjoern Peters, Simon Mallal, Elizabeth Phillips
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117160 (2015)
BACKGROUND:Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologica
Externí odkaz:
https://doaj.org/article/27198fc14dec4d6ea8faa113f4e62cca
Autor:
Abha Chopra, Simon Mallal, S. Roberts, Niamh M. Keane, Mina John, David Heckerman, Coral-Ann M. Almeida, Elizabeth McKinnon, Jonathan M. Carlson, C. Bronke
Publikováno v:
AIDS. 27:899-905
Objective: To define the relative frequencies of different mechanisms of viral escape. Design: A population-based approach to examine the distribution of HIV polymorphism associated with diverse population human leucocyte antigens (HLAs) at sites wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee583848bcbe4781b97ef2f3de1961c9
https://doi.org/10.1097/qad.0b013e32835e1616
https://doi.org/10.1097/qad.0b013e32835e1616
Autor:
S. Roberts, Carl M. Kadie, Abha Chopra, Niamh M. Keane, David W. Haas, David Heckerman, Simon Mallal, Mina John, Richard Haubrich, Jonathan M. Carlson, C. Bronke, Coral-Ann M. Almeida, Sharon A. Riddler, Elizabeth McKinnon
Publikováno v:
The Journal of Immunology. 187:2502-2513
Strong statistical associations between polymorphisms in HIV-1 population sequences and carriage of HLA class I alleles have been widely used to identify possible sites of CD8 T cell immune selection in vivo. However, there have been few attempts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f714d86bf7e4fbcdece53bbecab70d
https://doi.org/10.4049/jimmunol.1100691
https://doi.org/10.4049/jimmunol.1100691
Autor:
Simon Mallal, S. Roberts, M. Tschochner, E. Demaine, Niamh M. Keane, Coral-Ann M. Almeida, R. Laird, Tanya Krishnan, David Heckerman, Mina John, Jonathan M. Carlson, Ian James, Abha Chopra
Publikováno v:
Immunology and cell biology
HIV-1 mutations, which reduce or abolish CTL responses against virus-infected cells, are frequently selected in acute and chronic HIV infection. Among population HIV-1 sequences, immune selection is evident as human leukocyte antigen (HLA) allele-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61727ab413121e9459d772931b4601a
https://doi.org/10.1038/icb.2011.34
https://doi.org/10.1038/icb.2011.34
Autor:
Mina John, Niamh M. Keane
Publikováno v:
Biomarkers in Medicine. 5:113-116
HIV-1 is the cause of one of the most destructive pandemics in human history, with 33.4 million people currently infected worldwide [101]. Development of a vaccine that could prevent acquisition or disease associated with approximately 7000 new infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d9c9146a54c8e0899efb9be4b3a30f
https://doi.org/10.2217/bmm.11.23
https://doi.org/10.2217/bmm.11.23
Autor:
Carl M. Kadie, Abha Chopra, Simon Mallal, Imran Ahmad, Coral-Ann M. Almeida, R. Laird, Niamh M. Keane, Elizabeth McKinnon, David Heckerman, Mina John, S. Roberts
Publikováno v:
Vaccine. 28:6052-6057
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f724580c87d68bfd9e08efc2ca75830c
https://doi.org/10.1016/j.vaccine.2010.06.091
https://doi.org/10.1016/j.vaccine.2010.06.091
Autor:
Mina John, Niamh M. Keane, Imran Ahmed, Abha Chopra, Simon Mallal, S. Roberts, Joanne Turley, R. Laird, Katja Pfafferott, Coral-Ann M. Almeida, Elizabeth McKinnon, Andrew Lucas, Ben Rushton
Publikováno v:
Journal of Immunological Methods. 344:1-5
The enzyme linked immunospot (ELISpot) assay is a fundamental tool in cellular immunology, providing both quantitative and qualitative information on cellular cytokine responses to defined antigens. It enables the comprehensive screening of patient d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31de6ddaa6290037ff28abbe3a0bc60a
https://doi.org/10.1016/j.jim.2009.02.007
https://doi.org/10.1016/j.jim.2009.02.007
Publikováno v:
HIV Medicine. 8:148-155
Objectives: HIV-infected patients responding to combination antiretroviral therapy (ART) after experiencing severe immunodeficiency may exhibit persistent immune defects and occasionally experience opportunistic infections (OIs) despite increased CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22d1cd910e4b6d5aa84189adf292126
https://doi.org/10.1111/j.1468-1293.2007.00445.x
https://doi.org/10.1111/j.1468-1293.2007.00445.x
Autor:
Paul R Gorry, Silvia Lee, Niamh M. Keane, Martyn A. French, Lachlan Robert Gray, Patricia Price
Publikováno v:
Viral Immunology. 19:734-740
Here we address whether CCR5 or CXCR4 tropism of the predominant viral strain detected before or on combination antiretroviral therapy (ART) explains why some human immunodeficiency virus (HIV)-infected patients who begin ART with advanced HIV diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22a3e7ba67c5cc013d0b8e39c8412d2
https://doi.org/10.1089/vim.2006.19.734
https://doi.org/10.1089/vim.2006.19.734