Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Niamh M C Connolly"'
Autor:
Niraj Khemka, Gareth Morris, Laleh Kazemzadeh, Lara S. Costard, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Morten T. Venø, Jørgen Kjems, David C. Henshall, Jochen H. M. Prehn, Niamh M. C. Connolly
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in part, by mic
Externí odkaz:
https://doaj.org/article/aec36402be9d4848857dd99eb744d751
Autor:
Ujval Anilkumar, Petronela Weisova, Jasmin Schmid, Tytus Bernas, Heinrich J Huber, Heiko Düssmann, Niamh M C Connolly, Jochen H M Prehn
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188343 (2017)
Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically and genetically act
Externí odkaz:
https://doaj.org/article/49c93bc84e504a86b2d6d4a4501b1625
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148326 (2016)
Loss of ionic homeostasis during excitotoxic stress depletes ATP levels and activates the AMP-activated protein kinase (AMPK), re-establishing energy production by increased expression of glucose transporters on the plasma membrane. Here, we develop
Externí odkaz:
https://doaj.org/article/1e2157492c7c44b99be2b633903fc455
Autor:
Marie-Claire Fitzgerald, Philip J. O’Halloran, Sean A. Kerrane, Triona Ní Chonghaile, Niamh M. C. Connolly, Brona M. Murphy
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-15 (2023)
Abstract Medulloblastoma is the most common malignant paediatric brain tumour, representing 20% of all paediatric intercranial tumours. Current aggressive treatment protocols and the use of radiation therapy in particular are associated with high lev
Externí odkaz:
https://doaj.org/article/5694802bd4a44f729ddfe0998d1f6e3e
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain
Publikováno v:
American Journal of Physiology : Cell Physiology, 323, C69-c83
American Journal of Physiology-Cell Physiology, 323(1), C69-C83
American Journal of Physiology : Cell Physiology, 323, 1, pp. C69-c83
American Journal of Physiology-Cell Physiology 323 (2022) 1
American Journal of Physiology-Cell Physiology, 323(1), C69-C83
American Journal of Physiology : Cell Physiology, 323, 1, pp. C69-c83
American Journal of Physiology-Cell Physiology 323 (2022) 1
Reactive oxygen species (ROS) are recognized both as damaging molecules and intracellular signaling entities. In addition to its role in ATP generation, the mitochondrial electron transport chain (ETC) constitutes a relevant source of mitochondrial R
Autor:
Mona Heiland, Niamh M. C. Connolly, Ngoc T. Nguyen, Jaideep C. Kesavan, Kevin Fanning, Albert Sanfeliu, Yan Yan, Morten T. Venø, Lara S. Costard, Valentin Neubert, Thomas D. M. Hill, Felix Rosenow, Sebastian Bauer, Jørgen Kjems, Gareth Morris, David C. Henshall
There remains an urgent need for new therapies for drug-resistant epilepsy (DRE). Sodium channel blockers are effective for seizure control in common forms of epilepsy, but loss of sodium channel function underlies some genetic forms of epilepsy. App
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4289406f63ac047df965b97174eac70
https://doi.org/10.1101/2022.09.29.510105
https://doi.org/10.1101/2022.09.29.510105
Publikováno v:
Cell deathdisease. 13(5)
New, more effective therapeutics are required for the treatment of paediatric cancers. Current treatment protocols of cytotoxic treatments including chemotherapy trigger cancer-cell death by engaging the apoptosis pathway, and chemotherapy efficacy i
Autor:
Anna Tomašcová, Elisabeth Jirström, Bryan T. Hennessy, Alexa Resler, Petronela Weisová, Jochen H. M. Prehn, Mattia Cremona, Heiko Düssmann, Nikolaus Plesnila, Beatrice D'Orsi, Shona Pfeiffer, Niamh M. C. Connolly, Uta Mamrak, Stefan J. Haunsberger, Gang Chen
Publikováno v:
Journal of neurochemistryReferences. 159(4)
Progressive neuronal injury following ischaemic stroke is associated with glutamate-induced depolarization, energetic stress and activation of AMP-activated protein kinase (AMPK). We here identify a molecular signature associated with neuronal AMPK a
Autor:
Cristina R. Reschke, Junyi Su, Lara S. Costard, R. Jeroen Pasterkamp, Vamshidhar R. Vangoor, Gary P. Brennan, Federico Del Gallo, Tobias Engel, Valentin Neubert, Jochen H. M. Prehn, Aoife Campbell, Dennis Pultz, Lea M. Harder, Janosch P. Heller, Morten T. Venø, Yan Yan, David C. Henshall, Braxton A. Norwood, Jørgen Kjems, Niamh M. C. Connolly, Gareth Morris, Jens S. Andersen, Amaya Sanz-Rodriguez, Elena Langa, Stephanie Schorge, Felix Rosenow, Ajay Pal, Beatrice Salvetti, Karen Conboy, Juha Muilu, Paolo F. Fabene, Sebastian Bauer, Eva M. Jimenez-Mateos, Stefan J. Haunsberger, Amy Richardson
Publikováno v:
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Gallo, F D, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Del Gallo, F, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Del Gallo, F, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences of the United States of America
Significance Temporal lobe epilepsy is commonly drug resistant and is associated with dysregulated hippocampal gene expression. MicroRNAs are short noncoding RNAs which control protein levels by binding target mRNAs via Argonaute proteins. We sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef11a947b31811a4b5bce9f9ba6f9dd
https://pure.au.dk/ws/files/224579357/15977.full.pdf
https://pure.au.dk/ws/files/224579357/15977.full.pdf
Publikováno v:
J Neurosci
The Journal of Neuroscience
The Journal of Neuroscience
Mitochondrial clusters are found at regions of high-energy demand, allowing cells to meet local metabolic requirements while maintaining neuronal homeostasis. AMP-activated protein kinase (AMPK), a key energy stress sensor, responds to increases in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3fb84491ae80cdf880c3e8edb1fcf9
https://europepmc.org/articles/PMC7326360/
https://europepmc.org/articles/PMC7326360/