Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Niamh A. Leonard"'
Autor:
Serika D Naicker, Claire L Feerick, Kevin Lynch, Dawn Swan, Cian McEllistrim, Robert Henderson, Niamh A Leonard, Oliver Treacy, Alessandro Natoni, Athina Rigalou, Joana Cabral, Christopher Chiu, Kate Sasser, Thomas Ritter, Michael O’Dwyer, Aideen E Ryan
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Multiple Myeloma (MM) is a malignant disorder of plasma cells which, despite significant advances in treatment, remains incurable. Daratumumab, the first CD38 directed monoclonal antibody, has shown promising activity alone and in combination with ot
Externí odkaz:
https://doaj.org/article/c2aa7a8efc5244f4b92d73ee74984420
Autor:
Hannah Egan, Oliver Treacy, Kevin Lynch, Niamh A. Leonard, Grace O’Malley, Eileen Reidy, Aoise O’Neill, Shania M. Corry, Kim De Veirman, Karin Vanderkerken, Laurence J. Egan, Thomas Ritter, Aisling M. Hogan, Keara Redmond, Li Peng, Jenny Che, Wayne Gatlin, Pushpa Jayaraman, Margaret Sheehan, Aoife Canney, Sean O. Hynes, Emma M. Kerr, Philip D. Dunne, Michael E. O’Dwyer, Aideen E. Ryan
Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote tumor progression by enhancing immune cell suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5a9ff18739c6840bf4580074fd3b70
https://biblio.vub.ac.be/vubir/targeting-stromal-cell-sialylation-reverses-t-cellmediated-immunosuppression-in-the-tumor-microenvironment(1322be90-3ac7-43dd-8494-4ed572cf07ad).html
https://biblio.vub.ac.be/vubir/targeting-stromal-cell-sialylation-reverses-t-cellmediated-immunosuppression-in-the-tumor-microenvironment(1322be90-3ac7-43dd-8494-4ed572cf07ad).html
Autor:
Aideen E. Ryan, Laurence J. Egan, Thomas Ritter, Philip D. Dunne, Paul Lohan, Niamh A. Leonard, Serika D. Naicker, Kevin Lynch, Oliver Treacy, Grace O'Malley
Characterisation of primary BALB/c MSCs isolated from bone marrow, PD-L1 induction on MSC TNF-TCM is dependent on CT26 NF-κB activity, Validation of scrambled and PD-L1 shRNA transduced Balb/c MSCs - GFP expression and PD-L1 inhibition, Tumour burde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a61c546552ef02c383997114c02e32
https://doi.org/10.1158/2326-6066.22538954.v1
https://doi.org/10.1158/2326-6066.22538954.v1
Autor:
Aideen E. Ryan, Laurence J. Egan, Thomas Ritter, Philip D. Dunne, Paul Lohan, Niamh A. Leonard, Serika D. Naicker, Kevin Lynch, Oliver Treacy, Grace O'Malley
Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as infiltrating hematopoietic imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab876094850beb1c442bcdf4ca86e13
https://doi.org/10.1158/2326-6066.c.6548954.v1
https://doi.org/10.1158/2326-6066.c.6548954.v1
Autor:
Kerry Thompson, Frances R. Balkwill, Aideen E. Ryan, Emma McDermott, Eleonora Peerani, Elena Tomas Bort, Eileen Reidy, Niamh A Leonard, Daniela Loessner
Publikováno v:
Cancers
Cancers; Volume 13; Issue 23; Pages: 5998
Cancers, Vol 13, Iss 5998, p 5998 (2021)
Cancers; Volume 13; Issue 23; Pages: 5998
Cancers, Vol 13, Iss 5998, p 5998 (2021)
Simple Summary Colorectal cancer is the third most common type of cancer in the world. Immune cells and normal supporting cells (MSCs) within a tumour affect patient survival and change how well treatments work. This research aimed to develop a more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174a970f82fdafa7571963c5b51060c4
http://europepmc.org/articles/PMC8656544
http://europepmc.org/articles/PMC8656544
Autor:
Kevin Lynch, Sean O. Hynes, Michael O'Dwyer, Laurence J. Egan, Emma M. Kerr, Aideen E. Ryan, Kelly M. Redmond, K. DeVeirman, M. Craughwell, A. Canney, Hannah Egan, Phillip D. Dunne, Karin Vanderkerken, Oliver Treacy, Margaret Sheehan, Grace O’Malley, Aisling Hogan, Thomas Ritter, Niamh A Leonard
Immunosuppressive tumour microenvironments (TME) reduce the effectiveness of immune responses in cancer. Non-haematopoietic mesenchymal stromal cells (MSC), the precursor to cancer associated fibroblasts (CAFs), dictate tumour progression by enhancin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20db148b431cd3997a937e80a670dc25
https://doi.org/10.1101/2021.06.18.447879
https://doi.org/10.1101/2021.06.18.447879
Autor:
Kevin Lynch, Serika D. Naicker, Joana Cabral, Thomas Ritter, Oliver Treacy, Kate Sasser, Niamh A Leonard, Christopher Chiu, Dawn Swan, Alessandro Natoni, Cian McEllistrim, Athina Rigalou, Claire L. Feerick, Robert Henderson, Michael O'Dwyer, Aideen E. Ryan
Publikováno v:
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)
Multiple Myeloma (MM) is a malignant disorder of plasma cells which, despite significant advances in treatment, remains incurable. Daratumumab, the first CD38 directed monoclonal antibody, has shown promising activity alone and in combination with ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814613750f1cd53cb7e1e59642e64cd0
https://doi.org/10.1080/2162402x.2020.1859263
https://doi.org/10.1080/2162402x.2020.1859263
Autor:
Amir Nader, Hannah Egan, Sean O. Hynes, Oliver Treacy, Kevin Lynch, O Michael, Laurence J. Egan, Aideen E. Ryan, John Daly, Margaret Sheehan, Thomas Ritter, Aisling Hogan, Niamh A Leonard
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of cancer immunotherapies. Sialic acids, which exist as terminal sugars of glyco-conjugates, are highly expressed on cancer cells and are involved in various pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48256013579dbf5ee16e441ac43713df
https://doi.org/10.1136/jitc-2020-sitc2020.0865
https://doi.org/10.1136/jitc-2020-sitc2020.0865
Autor:
Eleonora Peerani, Niamh A Leonard, Daniela Loessner, Thomas Ritter, Grace O’Malley, Elena Tomas Bort, Oliver Treacy, Hannah Egan, Laurence J. Egan, Aideen E. Ryan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Colorectal cancer is the fourth most common occurring cancer and despite new treatment options it remains the third leading cause of cancer related deaths worldwide.1 Of the four Consensus Molecular Subtypes (CMS), the mesenchymal stromal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a0731d8f5da4636654227c1d5f09a4
https://doi.org/10.1136/jitc-2020-sitc2020.0864
https://doi.org/10.1136/jitc-2020-sitc2020.0864
Autor:
Philip D Dunne, Oliver Treacy, Serika D. Naicker, Laurence J. Egan, Aideen E. Ryan, Grace O’Malley, Kevin Lynch, Paul Lohan, Thomas Ritter, Niamh A Leonard
Publikováno v:
Cancer Immunology Research. 6:1426-1441
Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as infiltrating hematopoietic imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508c3cb33cd706fad3db5b381b91bb06
https://doi.org/10.1158/2326-6066.cir-17-0443
https://doi.org/10.1158/2326-6066.cir-17-0443