Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Niall S. Kenneth"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but also participates in inflammatory signalling, copper homeostasis, response to hypo
Externí odkaz:
https://doaj.org/article/36168ae2c8b04b3fb7adce3cdb9a7444
Publikováno v:
Cells, Vol 10, Iss 6, p 1425 (2021)
PBRM1, a component of the chromatin remodeller SWI/SNF, is often deleted or mutated in human cancers, most prominently in renal cancers. Core components of the SWI/SNF complex have been shown to be important for the cellular response to hypoxia. Here
Externí odkaz:
https://doaj.org/article/9182d3804c3040e795b561faf9fa5eae
Publikováno v:
Cells, Vol 8, Iss 2, p 114 (2019)
Hypoxia-Inducible Factors (HIFs) play essential roles in the physiological response to low oxygen in all multicellular organisms, while their deregulation is associated with human diseases. HIF levels and activity are primarily controlled by the avai
Externí odkaz:
https://doaj.org/article/d347005283f1403ab16e03bb017a3b1d
Autor:
Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2087-2113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420474f3df9a1bc6e42295d95643c992
https://doi.org/10.1042/bcj20220089
https://doi.org/10.1042/bcj20220089
Autor:
Mushtaq M. Khazeem, John W. Casement, George Schlossmacher, Niall S. Kenneth, Nielda K. Sumbung, Janice Yuen Tung Chan, Jade F. McGow, Ian G. Cowell, Caroline A. Austin
Publikováno v:
Molecular Neurobiology. 59:5987-6008
The neuroblastoma cell line SH-SY5Y is widely used to study retinoic acid (RA)-induced gene expression and differentiation and as a tool to study neurodegenerative disorders. SH-SY5Y cells predominantly exhibit adrenergic neuronal properties, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20e08068569b3c67ef1999bcf74dafc0
https://doi.org/10.1007/s12035-022-02949-6
https://doi.org/10.1007/s12035-022-02949-6
Publikováno v:
Biochemical Journal. 479:245-257
Hypoxia is a common denominator in the pathophysiology of a variety of human disease states. Insight into how cells detect, and respond to low oxygen is crucial to understanding the role of hypoxia in disease. Central to the hypoxic response is rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a911e492997eace5b847fd05aa17689
https://doi.org/10.1042/bcj20210554
https://doi.org/10.1042/bcj20210554
Autor:
Amy Collins, Rebecca Scott, Caroline L Wilson, Giuseppe Abbate, Gabrielle Ecclestone, Demi Biddles, Fiona Oakley, Jelena Mann, Derek A Mann, Niall S. Kenneth
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in most types of chronic liver diseases. Fibrosis is associated with the activation of hepatic stellate cells (HSCs) which transdifferentiate into a myofibrobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e58ae1c2dda8639cd417d5c143776
https://doi.org/10.1101/2023.01.08.523142
https://doi.org/10.1101/2023.01.08.523142
Autor:
Jill E Hunter, Oliver McHugh, Gabrielle B Ecclestone, Fraser Child, Hannah Mearns, Georgia Robson, Molly Dadzie, Sonia Rocha, Neil D Perkins, Niall S Kenneth
Adaptation to reduced oxygen availability is mediated by the hypoxia-inducible factor (HIF) family of transcription factors. The activity and availability of HIF proteins is primarily driven by the stability of the HIF alpha subunits. However, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21477b44379fc42e31ee1b732ec577a5
https://doi.org/10.1101/2022.11.02.514731
https://doi.org/10.1101/2022.11.02.514731
Autor:
Mushtaq M, Khazeem, John W, Casement, George, Schlossmacher, Niall S, Kenneth, Nielda K, Sumbung, Janice Yuen Tung, Chan, Jade F, McGow, Ian G, Cowell, Caroline A, Austin
Publikováno v:
Molecular neurobiology. 59(10)
The neuroblastoma cell line SH-SY5Y is widely used to study retinoic acid (RA)-induced gene expression and differentiation and as a tool to study neurodegenerative disorders. SH-SY5Y cells predominantly exhibit adrenergic neuronal properties, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c53e2f185848a38a50ae61bd7e91723
https://pubmed.ncbi.nlm.nih.gov/35831557
https://pubmed.ncbi.nlm.nih.gov/35831557
Autor:
Thiago Varga, Elsje G. Otten, Filippo Scialò, Gareth G. Lavery, Daniel G. Anderson, Shinji Saiki, Ryan Tasseff, Oliver D. K. Maddocks, David Cartwright, Niall S. Kenneth, Congxin Sun, Joerg Gsponer, Carl Ward, Luiz Felipe Souza E Silva, Rudolf Jaenisch, Tatiana R. Rosenstock, Manolis Papamichos-Chronakis, Malgorzata Zatyka, Kei-Ichi Ishikawa, Elena Seranova, Dorothea Maetzel, Sovan Sarkar, Masaya Imoto, Michael Lazarou, Haoyi Wang, David Shapira, Adina Maria Palhegyi, Kevin J. Kauffman, Rhoda Stefanatos, Malkiel A. Cohen, Lucia Sedlackova, Robert J. Isfort, Prashanta Kumar Panda, Tetsushi Kataura, Charles C. Bascom, Miruna Chipara, Gaurav Sahay, Alberto Sanz, Yosef Buganim, John Erich Oblong, Shupei Zhang, Satomi Miwa, Tong Zhang, Animesh Acharjee, Viktor I. Korolchuk, Jorge Torresi
Autophagy is an essential catabolic process that promotes the clearance of surplus or damaged intracellular components1. As a recycling process, autophagy is also important for the maintenance of cellular metabolites to aid metabolic homeostasis2. Lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2832b802172e30ef5e271ca98c298b
https://doi.org/10.21203/rs.3.rs-659023/v1
https://doi.org/10.21203/rs.3.rs-659023/v1