Výsledky vyhledávání - "Niall M. Mangan"

Akademický článek

Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

Autor: Ashty S. Karim, Dylan M. Brown, Chloé M. Archuleta, Sharisse Grannan, Ludmilla Aristilde, Yogesh Goyal, Josh N. Leonard, Niall M. Mangan, Arthur Prindle, Gabriel J. Rocklin, Keith J. Tyo, Laurie Zoloth, Michael C. Jewett, Susanna Calkins, Neha P. Kamat, Danielle Tullman-Ercek, Julius B. Lucks

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Synthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society’s most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges t

Externí odkaz: https://doaj.org/article/65b629648b2a423697700487a37f6292

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Akademický článek

Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology

Autor: Carolyn E. Mills, Curt Waltmann, Andre G. Archer, Nolan W. Kennedy, Charlotte H. Abrahamson, Alexander D. Jackson, Eric W. Roth, Sasha Shirman, Michael C. Jewett, Niall M. Mangan, Monica Olvera de la Cruz, Danielle Tullman-Ercek

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Morphology of metabolosomes affects the encapsulated pathway performance. Here, the authors combine experimental characterizations with structural and kinetic modeling to reveal how the shell protein PduN changes the morphology of 1,2-propanediol uti

Externí odkaz: https://doaj.org/article/75ed84d7392241a4a693c4368036bc9f

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Mega-scale experimental analysis of protein folding stability in biology and protein design

Autor: Kotaro Tsuboyama, Justas Dauparas, Jonathan Chen, Elodie Laine, Yasser Mohseni Behbahani, Jonathan J. Weinstein, Niall M. Mangan, Sergey Ovchinnikov, Gabriel J. Rocklin

Datasets and scriptsfor BioRixv manuscript titled "Mega-scale experimental analysis of protein folding stability in biology and protein design" URL:https://doi.org/10.1101/2022.12.06.519132 *** IMPORTANT! Pleaseregister your useof these data so that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c29576efc048a875a7591248b13d35

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Modelling the pyrenoid-based CO2-concentrating mechanism provides insights into its operating principles and a roadmap for its engineering into crops

Autor: Chenyi Fei, Alexandra T. Wilson, Niall M. Mangan, Ned S. Wingreen, Martin C. Jonikas

Publikováno v: Nature Plants. 8:583-595

Many eukaryotic photosynthetic organisms enhance their carbon uptake by supplying concentrated CO2 to the CO2-fixing enzyme Rubisco in an organelle called the pyrenoid. Ongoing efforts seek to engineer this pyrenoid-based CO2-concentrating mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1344bfe256ee9de7764de03953d7422
https://doi.org/10.1038/s41477-022-01153-7

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Akademický článek

A systems-level model reveals that 1,2-Propanediol utilization microcompartments enhance pathway flux through intermediate sequestration.

Autor: Christopher M Jakobson, Danielle Tullman-Ercek, Marilyn F Slininger, Niall M Mangan

Publikováno v: PLoS Computational Biology, Vol 13, Iss 5, p e1005525 (2017)

The spatial organization of metabolism is common to all domains of life. Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spatially organize the metabolism of pathogenicity-relevant carbon sources, such as

Externí odkaz: https://doaj.org/article/9fc2c4045f20493f9b8ebee6f723c3a5

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Linking the Salmonella enterica 1,2-Propanediol Utilization Bacterial Microcompartment Shell to the Enzymatic Core via the Shell Protein PduB

Autor: Nolan W. Kennedy, Carolyn E. Mills, Charlotte H. Abrahamson, Andre G. Archer, Sasha Shirman, Michael C. Jewett, Niall M. Mangan, Danielle Tullman-Ercek

Publikováno v: J Bacteriol

Bacterial microcompartments (MCPs) are protein-based organelles that house the enzymatic machinery for metabolism of niche carbon sources, allowing enteric pathogens to outcompete native microbiota during host colonization. While much progress has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87f9b7dec4308e57fbea8da2bdef3c3
https://europepmc.org/articles/PMC9487594/

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Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology

Autor: Carolyn E, Mills, Curt, Waltmann, Andre G, Archer, Nolan W, Kennedy, Charlotte H, Abrahamson, Alexander D, Jackson, Eric W, Roth, Sasha, Shirman, Michael C, Jewett, Niall M, Mangan, Monica, Olvera de la Cruz, Danielle, Tullman-Ercek

Publikováno v: Nature communications. 13(1)

Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study compartment morpholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfa541455eae51cb0ceed3846dbd3b17
https://pubmed.ncbi.nlm.nih.gov/35768404

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