Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer

Autor: Jie Feng, Varun Pathak, Niall M. Byrne, Tongchuan Wang, Cancan Yin, Reinhold J. Medina, Jonathan A. Coulter

Publikováno v: Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract Background Radiotherapy is a major therapeutic modality for locally advanced head and neck cancer. However, the effectiveness of radiotherapy is hindered by resistance mechanisms, most notably hypoxia, leading to unfavourable treatment outco

Externí odkaz: https://doaj.org/article/6ec043eac81e45ccacb1ebbd44bfc35c

Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives

Autor: Jonathan A. Coulter, Niall M. Byrne, Prajakta Tambe

Publikováno v: Byrne, N M, Tambe, P & Coulter, J A 2021, ' Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives ', Journal of Personalized Medicine, vol. 11, no. 1, 53 . https://doi.org/10.3390/jpm11010053
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 53, p 53 (2021)

Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, tumour cells can become resistant to RT, leading to disease recurrence. Components of the tumour microenvironment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21283d34c10d97b051d2b95be3e5b3c0
https://pure.qub.ac.uk/en/publications/radiation-response-in-the-tumour-microenvironment-predictive-biomarkers-and-future-perspectives(033a64d0-5c7a-4023-bc1e-cf5e9205bb25).html

Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development

Autor: Niall M. Byrne, Wafa Al Jamal, Jonathan A. Coulter, Jie Feng

Publikováno v: Feng, J, Byrne, N M, Al Jamal, W & Coulter, J A 2019, ' Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development ', Cancers, vol. 11, no. 12, 1989 . https://doi.org/10.3390/cancers11121989
Cancers

Hypoxia is one of the most common phenotypes of malignant tumours. Hypoxia leads to the increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes controlling a raft of pro-tumour phenotypes. These include maintena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c9505fa97a4f4699f54e9d7776490d
https://doi.org/10.3390/cancers11121989

Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant progression

Autor: Heather Nesbitt, Rachel J. Errington, Jenny Worthington, Paul Smith, Nicole Williams, Laurence H. Patterson, Niall M. Byrne, Declan J. McKenna, Stephanie R. McKeown, Louise Ming

Purpose: To understand the role of hypoxia in prostate tumor progression and to evaluate the ability of the novel unidirectional hypoxia-activated prodrug OCT1002 to enhance the antitumor effect of bicalutamide. Experimental Design: The effect of OCT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2591fab3cd96ca64d2e22738e62cb057

Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: Informed scheduling of the bioreductive drug AQ4N improves treatment response

Autor: Niall M. Byrne, Christopher A. Mitchell, David Waugh, Claire Ward, Louise Ming, Sarah Nicole Camac, Jenny Worthington, Stephanie R. McKeown

Publikováno v: International Journal of Cancer. 132:1323-1332

Androgen withdrawal induces hypoxia in androgen-sensitive tissue; this is important as in the tumour microenvironment, hypoxia is known to drive malignant progression. Our study examined the time-dependent effect of androgen deprivation therapy (ADT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1e4ba0bc9a29b5ba7ea0f94a4215cf
https://doi.org/10.1002/ijc.27796