Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Niall J, Lennon"'
Autor:
Eric Venner, Donna Muzny, Joshua D. Smith, Kimberly Walker, Cynthia L. Neben, Christina M. Lockwood, Phillip E. Empey, Ginger A. Metcalf, Chris Kachulis, The All of Us Research Program Regulatory Working Group, Sana Mian, Anjene Musick, Heidi L. Rehm, Steven Harrison, Stacey Gabriel, Richard A. Gibbs, Deborah Nickerson, Alicia Y. Zhou, Kimberly Doheny, Bradley Ozenberger, Scott E. Topper, Niall J. Lennon
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background The All of Us Research Program (AoURP, “the program”) is an initiative, sponsored by the National Institutes of Health (NIH), that aims to enroll one million people (or more) across the USA. Through repeated engagement of part
Externí odkaz:
https://doaj.org/article/e910cd798cad40ff995d316fed013e1c
Autor:
Zachary T. Weber, Katharine A. Collier, David Tallman, Juliet Forman, Sachet Shukla, Sarah Asad, Justin Rhoades, Samuel Freeman, Heather A. Parsons, Nicole O. Williams, Romualdo Barroso-Sousa, Elizabeth H. Stover, Haider Mahdi, Carrie Cibulskis, Niall J. Lennon, Gavin Ha, Viktor A. Adalsteinsson, Sara M. Tolaney, Daniel G. Stover
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background Circulating tumor DNA (ctDNA) offers minimally invasive means to repeatedly interrogate tumor genomes, providing opportunities to monitor clonal dynamics induced by metastasis and therapeutic selective pressures. In metastatic can
Externí odkaz:
https://doaj.org/article/c88b661c2dd14e5595a5247ba01a0bfe
Autor:
Maura Costello, Mark Fleharty, Justin Abreu, Yossi Farjoun, Steven Ferriera, Laurie Holmes, Brian Granger, Lisa Green, Tom Howd, Tamara Mason, Gina Vicente, Michael Dasilva, Wendy Brodeur, Timothy DeSmet, Sheila Dodge, Niall J. Lennon, Stacey Gabriel
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Here we present an in-depth characterization of the mechanism of sequencer-induced sample contamination due to the phenomenon of index swapping that impacts Illumina sequencers employing patterned flow cells with Exclusion Amplifi
Externí odkaz:
https://doaj.org/article/2079b2d7551942bc810c187c8e5c737e
Autor:
Junko Tsuji, Tianyu Li, Albert Grinshpun, Tim Coorens, Douglas Russo, Leilani Anderson, Rebecca Rees, Agostina Nardone, Candace Patterson, Niall J. Lennon, Carrie Cibulskis, Ignaty Leshchiner, Nabihah Tayob, Sara M. Tolaney, Nadine Tung, Donald P. McDonnell, Ian E. Krop, Eric P. Winer, Chip Stewart, Gad Getz, Rinath Jeselsohn
Publikováno v:
Clin Cancer Res
Purpose: Sensitivity to endocrine therapy (ET) is critical for the clinical benefit from the combination of palbociclib plus ET in hormone receptor–positive/HER2-negative (HR+/HER2−) advanced breast cancer. Bazedoxifene is a third-generation sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4a380680b3c39ba86a4b9cb2d2845e
https://doi.org/10.1158/1078-0432.ccr-22-2305
https://doi.org/10.1158/1078-0432.ccr-22-2305
Autor:
Alanna J. Church, Laura B. Corson, Pei-Chi Kao, Alma Imamovic-Tuco, Deirdre Reidy, Duong Doan, Wenjun Kang, Navin Pinto, Luke Maese, Theodore W. Laetsch, AeRang Kim, Susan I. Colace, Margaret E. Macy, Mark A. Applebaum, Rochelle Bagatell, Amit J. Sabnis, Daniel A. Weiser, Julia L. Glade-Bender, Alan C. Homans, John Hipps, Haley Harris, Danielle Manning, Alyaa Al-Ibraheemi, Yvonne Li, Hersh Gupta, Andrew D. Cherniack, Ying-Chun Lo, Gianna R. Strand, Lobin A. Lee, R. Seth Pinches, Lorena Lazo De La Vega, Maegan V. Harden, Niall J. Lennon, Seong Choi, Hannah Comeau, Marian H. Harris, Suzanne J. Forrest, Catherine M. Clinton, Brian D. Crompton, Junne Kamihara, Laura E. MacConaill, Samuel L. Volchenboum, Neal I. Lindeman, Eliezer Van Allen, Steven G. DuBois, Wendy B. London, Katherine A. Janeway
Publikováno v:
Nature Medicine. 28:1581-1589
To evaluate the clinical impact of molecular tumor profiling (MTP) with targeted sequencing panel tests, pediatric patients with extracranial solid tumors were enrolled in a prospective observational cohort study at 12 institutions. In the 345-patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75b332c2f85a30c85057cb884374062
https://doi.org/10.1038/s41591-022-01856-6
https://doi.org/10.1038/s41591-022-01856-6
Autor:
Ryan B. Corcoran, Levi A. Garraway, Jeffrey A. Engelman, A. John Iafrate, Dora Dias-Santagata, Gad Getz, Mari Mino-Kenudson, Tiffany G. Huynh, Niall J. Lennon, Lisa M. Green, Kristin Anderka, Samira Bahl, Joseph M. Gurski, Anuj Kalsy, Elizabeth L. Lockerman, Craig H. Mermel, Kerry D. Lynch, Koki Nishimura, Jason T. Godfrey, Jason E. Faris, Eunice L. Kwak, Nikhil Wagle, Eliezer M. Van Allen, Erin M. Sennott, Leanne G. Ahronian
Supplementary Figure S5. Role of ARAF Q489L and MEK F53L in resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159b92665530fed33babe57bbb3fb25d
https://doi.org/10.1158/2159-8290.22530041.v1
https://doi.org/10.1158/2159-8290.22530041.v1
Autor:
Ryan B. Corcoran, Levi A. Garraway, Jeffrey A. Engelman, A. John Iafrate, Dora Dias-Santagata, Gad Getz, Mari Mino-Kenudson, Tiffany G. Huynh, Niall J. Lennon, Lisa M. Green, Kristin Anderka, Samira Bahl, Joseph M. Gurski, Anuj Kalsy, Elizabeth L. Lockerman, Craig H. Mermel, Kerry D. Lynch, Koki Nishimura, Jason T. Godfrey, Jason E. Faris, Eunice L. Kwak, Nikhil Wagle, Eliezer M. Van Allen, Erin M. Sennott, Leanne G. Ahronian
Supplementary Table S1. Patient characteristics and MAPK pathway reactivating resistance mechanisms of BRAF-mutant CRC patients with clinical acquired resistance to RAF/EGFR or RAF/MEK inhibitor combinations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68672d23e9c3704897ff3623acae1192
https://doi.org/10.1158/2159-8290.22530038
https://doi.org/10.1158/2159-8290.22530038
Autor:
Rinath Jeselsohn, Gad Getz, Chip Stewart, Eric P. Winer, Ian E. Krop, Donald P. McDonnell, Nadine Tung, Sara M. Tolaney, Nabihah Tayob, Ignaty Leshchiner, Carrie Cibulskis, Niall J. Lennon, Candace Patterson, Agostina Nardone, Rebecca Rees, Leilani Anderson, Douglas Russo, Tim Coorens, Albert Grinshpun, Tianyu Li, Junko Tsuji
Supplemental Figure 1: Consort diagram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0611c7ec660f81a872f9a9bf87053e68
https://doi.org/10.1158/1078-0432.22489286.v1
https://doi.org/10.1158/1078-0432.22489286.v1
Autor:
Rinath Jeselsohn, Gad Getz, Chip Stewart, Eric P. Winer, Ian E. Krop, Donald P. McDonnell, Nadine Tung, Sara M. Tolaney, Nabihah Tayob, Ignaty Leshchiner, Carrie Cibulskis, Niall J. Lennon, Candace Patterson, Agostina Nardone, Rebecca Rees, Leilani Anderson, Douglas Russo, Tim Coorens, Albert Grinshpun, Tianyu Li, Junko Tsuji
Supplementary tables 1-4 and supplementary figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e32f73a32535a90e87176f921e9a05
https://doi.org/10.1158/1078-0432.22489268.v1
https://doi.org/10.1158/1078-0432.22489268.v1
Autor:
Rinath Jeselsohn, Gad Getz, Chip Stewart, Eric P. Winer, Ian E. Krop, Donald P. McDonnell, Nadine Tung, Sara M. Tolaney, Nabihah Tayob, Ignaty Leshchiner, Carrie Cibulskis, Niall J. Lennon, Candace Patterson, Agostina Nardone, Rebecca Rees, Leilani Anderson, Douglas Russo, Tim Coorens, Albert Grinshpun, Tianyu Li, Junko Tsuji
Supplemental Figure 5: SSNVs detected in the cancer-related genes across 68 ctDNA WES samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2537b3c2d2976e14fe44736fc0f6d59
https://doi.org/10.1158/1078-0432.22489274.v1
https://doi.org/10.1158/1078-0432.22489274.v1