Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Niall D. Geoghegan"'
Autor:
Georgia K. Atkin-Smith, Jascinta P. Santavanond, Amanda Light, Joel S. Rimes, Andre L. Samson, Jeremy Er, Joy Liu, Darryl N. Johnson, Mélanie Le Page, Pradeep Rajasekhar, Raymond K. H. Yip, Niall D. Geoghegan, Kelly L. Rogers, Catherine Chang, Vanessa L. Bryant, Mai Margetts, M. Cristina Keightley, Trevor J. Kilpatrick, Michele D. Binder, Sharon Tran, Erinna F. Lee, Walter D. Fairlie, Dilara C. Ozkocak, Andrew H. Wei, Edwin D. Hawkins, Ivan K. H. Poon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and shear force that can induce cellular da
Externí odkaz:
https://doaj.org/article/12adadfbad504a22aba93116f2876b03
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Lung-Yu Liang, Niall D. Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W. Whitehead, Minglyanna G. Surudoi, Samuel N. Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L. Rogers, James M. Murphy, Isabelle S. Lucet
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract EphB6 is an understudied ephrin receptor tyrosine pseudokinase that is downregulated in multiple types of metastatic cancers. Unlike its kinase-active counterparts which autophosphorylate and transmit signals upon intercellular interaction,
Externí odkaz:
https://doaj.org/article/57b7b70f20284071a21e40f20591480e
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Azelle Hawdon, Niall D. Geoghegan, Monika Mohenska, Anja Elsenhans, Charles Ferguson, Jose M. Polo, Robert G. Parton, Jennifer Zenker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The spatial sorting of RNA transcripts is fundamental for the refinement of gene expression to distinct subcellular regions. Although, in non-mammalian early embryogenesis, differential RNA localisation presages cell fate determination, in m
Externí odkaz:
https://doaj.org/article/3093f793cc1d41fd8f0d24d20c718b39
Autor:
Niall D. Geoghegan, Cindy Evelyn, Lachlan W. Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S. Marapana, Daryan Kempe, Jennifer K. Thompson, Michael J. Mlodzianoski, Julie Healer, Maté Biro, Alan F. Cowman, Kelly L. Rogers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocy
Externí odkaz:
https://doaj.org/article/772dfa5515904e51b6b3f89dfb973a19
Autor:
Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumul
Externí odkaz:
https://doaj.org/article/1ae829760f7e467a8e81c5fd0160cbfe
Autor:
Silke Morris, Niall D. Geoghegan, Jessica B.A. Sadler, Anna M. Koester, Hannah L. Black, Marco Laub, Lucy Miller, Linda Heffernan, Jeremy C. Simpson, Cynthia C. Mastick, Jon Cooper, Nikolaj Gadegaard, Nia J. Bryant, Gwyn W. Gould
Publikováno v:
PeerJ, Vol 8, p e8751 (2020)
Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delivery of glucose transporter (GLUT4)-containing vesicles from intracellular stores to the cell surface. Fusion of these ves
Externí odkaz:
https://doaj.org/article/844e6178d6f1458589e68000a046bb94
Autor:
Stephen W. Scally, Tony Triglia, Cindy Evelyn, Benjamin A. Seager, Michał Pasternak, Pailene S. Lim, Julie Healer, Niall D. Geoghegan, Amy Adair, Wai-Hong Tham, Laura F. Dagley, Kelly L. Rogers, Alan F. Cowman
Publikováno v:
Nature Microbiology. 7:2039-2053
The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an essential step in this process involves the ligand PfRh5, which forms a complex with cysteine-rich protective antigen (CyRPA) and Pf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e1eed347241e12f560ee42fa34e52ad
https://doi.org/10.1038/s41564-022-01261-2
https://doi.org/10.1038/s41564-022-01261-2
Autor:
Sant-Rayn Pasricha, Benjamin Solomon, Janine Campbell, David Westerman, Susan O'Mahoney, Niall D. Geoghegan, Kelly L. Rogers, Susan Wilson, James A. Kuzich, Sarah Heynemann, Cindy Evelyn
Publikováno v:
Pathology. 53:608-612
We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic lymphoma kinase (ALK) which is considered standard first-line treatment for patients with ALK-rearranged advanced non-smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46b75459e171b0154521974ddc5fbf1
https://doi.org/10.1016/j.pathol.2020.10.023
https://doi.org/10.1016/j.pathol.2020.10.023