Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Niall D MacHugh"'
Autor:
Shan Goh, Daniel Ngugi, Regina Lizundia, Isabel Hostettler, Kerry Woods, Keith Ballingall, Niall D MacHugh, W Ivan Morrison, Willie Weir, Brian Shiels, Dirk Werling
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162571 (2016)
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle. Five
Externí odkaz:
https://doaj.org/article/9bdff7d4b71c40cfb57718abcffd4b3b
Autor:
Isabel K Macdonald, Maria Harkiolaki, Lawrence Hunt, Timothy Connelley, A Victoria Carroll, Niall D MacHugh, Simon P Graham, E Yvonne Jones, W Ivan Morrison, Darren R Flower, Shirley A Ellis
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001149 (2010)
T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited
Externí odkaz:
https://doaj.org/article/dc0bc3cc205e45e6bb0790896cba9fc0
Publikováno v:
The Journal of general virology. 98(7)
In common with other herpes viruses, bovine herpes virus 1 (BHV-1) induces strong virus-specific CD8 T-cell responses. However, there is a paucity of information on the antigenic specificity of the responding T-cells. The development of a system to g
Autor:
William Weir, Shan Goh, Daniel Ngugi, Regina Lizundia, Niall D. MacHugh, Keith T. Ballingall, Dirk Werling, Brian Shiels, Kerry Woods, Isabel Hostettler, W. Ivan Morrison
Publikováno v:
PLoS One
PLoS ONE, Vol 11, Iss 9, p e0162571 (2016)
PLoS ONE
Goh, S, Ngugi, D, Lizundia, R, Hostettler, I, Woods, K, Ballingall, K, MacHugh, N D, Morrison, W I, Weir, W, Shiels, B & Werling, D 2016, ' Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells ', PLoS ONE, vol. 11, no. 9, e0162571 . https://doi.org/10.1371/journal.pone.0162571
PLoS ONE, Vol 11, Iss 9, p e0162571 (2016)
PLoS ONE
Goh, S, Ngugi, D, Lizundia, R, Hostettler, I, Woods, K, Ballingall, K, MacHugh, N D, Morrison, W I, Weir, W, Shiels, B & Werling, D 2016, ' Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells ', PLoS ONE, vol. 11, no. 9, e0162571 . https://doi.org/10.1371/journal.pone.0162571
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle. Five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c4fc10db5ab4fb67bd6060c9b824b5
https://eprints.gla.ac.uk/124453/1/124453.pdf
https://eprints.gla.ac.uk/124453/1/124453.pdf
Autor:
Sarah C. Gilbert, Victor Riitho, Julius Osaso, Fredrick O. Onono, Roger Pelle, Duncan Mwangi, Evans L. N. Taracha, Elias Awino, John K. Nyanjui, W. Ivan Morrison, Jean-Christophe Audonnet, Yoshikazu Honda, Declan J. McKeever, Evelyne Abuya, Mat Yamage, Niall D. MacHugh, Anthony M. Muthiani, Pierre van der Bruggen, Cecelia Muriuki, Ramadhan S. Mwakubambanya, Simon P. Graham, Ferdinand Mbwika, Etienne P. de Villiers, James Gachanja, Shirley A. Ellis, Rosemary Saya
Publikováno v:
Graham, S P, Pelle, R, Yamage, M, Mwangi, D M, Honda, Y, Mwakubambanya, R S, de Villiers, E P, Abuya, E, Awino, E, Gachanja, J, Mbwika, F, Muthiani, A M, Muriuki, C, Nyanjui, J K, Onono, F O, Osaso, J, Riitho, V, Saya, R M, Ellis, S A, McKeever, D J, MacHugh, N D, Gilbert, S C, Audonnet, J C, Morrison, W I, van der Bruggen, P & Taracha, E L 2008, ' Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva ', Infection and Immunity, vol. 76, no. 2, pp. 685-694 . https://doi.org/10.1128/IAI.01244-07
Immunity against the bovine intracellular protozoan parasiteTheileria parvahas been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells fromT. parva-immune cattle of different major histocompatibility complex (MHC) genotypes hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e9fc8ddaca2c02fde7f5299cccf6c3
https://ora.ox.ac.uk/objects/uuid:cd52a113-54a5-4e55-b90e-a1f4f12d0e41
https://ora.ox.ac.uk/objects/uuid:cd52a113-54a5-4e55-b90e-a1f4f12d0e41
Autor:
Johanneke D, Hemmink, William, Weir, Niall D, MacHugh, Simon P, Graham, Ekta, Patel, Edith, Paxton, Brian, Shiels, Philip G, Toye, W Ivan, Morrison, Roger, Pelle
Publikováno v:
International Journal for Parasitology
Graphical abstract
Highlights • Genotyping and gene sequencing reveal limited diversity in a live Theileria parva vaccine. • Two of the vaccine components show a high level of similarity at all loci. • The vaccine contains very little of t
Highlights • Genotyping and gene sequencing reveal limited diversity in a live Theileria parva vaccine. • Two of the vaccine components show a high level of similarity at all loci. • The vaccine contains very little of t
Publikováno v:
The Journal of Immunology. 187:5910-5920
Polymorphism of immunodominant CD8+ T cell epitopes can facilitate escape from immune recognition of pathogens, leading to strain-specific immunity. In this study, we examined the TCR β-chain (TRB) diversity of the CD8+ T cell responses of cattle ag
Publikováno v:
Machugh, N D, Burrells, A C & Morrison, W I 2008, ' Demonstration of strain-specific CD8 T cell responses to Theileria annulata ', Parasite Immunology, vol. 30, no. 8, pp. 385-393 . https://doi.org/10.1111/j.1365-3024.2008.01038.x
Parasite Immunology
Parasite Immunology
SUMMARY The present study set out to examine the nature and specificity of the bovine CD8 T cell response at the clonal level in a group of eight animals immunized with a cloned population of Theileria annulata. The results demonstrated that immunize
Autor:
Tracey J. Coffey, Christopher Pennelegion, Amanda Stalker, Dave Burt, Yoshika Yamakawa, Niall D. MacHugh, Dirk Werling, Sam Willcocks
Publikováno v:
Journal of Leukocyte Biology. 83:1396-1403
Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variet
Publikováno v:
Rocchi, M S, Ballingall, K T, Ngugi, D, MacHugh, N & McKeever, D 2008, ' A rapid and sensitive intracellular flow cytometric assay to identify Theileria parva infection within target cells ', Parasitology, vol. 135, no. 2, pp. 195-201 . https://doi.org/10.1017/S0031182007003678
SUMMARYTheileria parvais an intracellular protozoan parasite transmitted by ticks that causes a fatal lymphoproliferative disease of cattle known as East Coast Fever. Vaccination against the disease currently relies on inoculation of the infective sp