Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain

Autor: Fiona E. Holmes, Craig A. McArdle, Ying-Ju Chen, Penny Vanderplank, David Wynick, Niall C. H. Kerr

Publikováno v: Molecular and Cellular Neurosciences
Holmes, F E, Kerr, N C H, Vanderplank, P A, McArdle, C & Wynick, D 2017, ' Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain ', Molecular and Cellular Neuroscience, vol. 78, pp. 35-40 . https://doi.org/10.1016/j.mcn.2016.11.010

Background Gpr151 is an orphan GPCR whose function is unknown. The restricted pattern of neuronal expression in the habenula, dorsal horn of the spinal cord and dorsal root ganglion plus homology with the galanin family of receptors imply a role in n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99159b1585a2103101348caa620c6954
https://pubmed.ncbi.nlm.nih.gov/27913310

Galanin – 25 years with a multitalented neuropeptide

Autor: Sally A. Hobson, David Wynick, Niall C. H. Kerr, C. R. Elliot-Hunt, Andrea Bacon, Robert J P Pope, Penny Vanderplank, Fiona E. Holmes

Publikováno v: Cellular and Molecular Life Sciences. 65:1806-1812

The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous system. Its expression is markedly upregulated in many neuronal tissues after nerve injury or disease. Over the last 10 years we have demonstrated that the pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24341017b4b4694e322350225a3db74e
https://doi.org/10.1007/s00018-008-8154-7

Osteopontin expression and function within the dorsal root ganglion

Autor: Niall C. H. Kerr, David T. Denhardt, Nathalie Isles, David Wynick, Barnaby C.L. Marsh

Publikováno v: NeuroReport. 18:153-157

Osteopontin expression has previously been demonstrated in the adult rat dorsal root ganglion, although its function remains unclear. Here, we demonstrate, using real-time reverse transcription-polymerase (RT-PCR) chain reaction, that osteopontin mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fc7ea14290d109f4c7a88d37470530
https://doi.org/10.1097/wnr.0b013e328010d4fa

Novel Isoforms of the Sodium Channels Nav1.8 and Nav1.5 Are Produced by a Conserved Mechanism in Mouse and Rat

Autor: David Wynick, Fiona E. Holmes, Niall C. H. Kerr

Publikováno v: Journal of Biological Chemistry. 279:24826-24833

The voltage-gated sodium channel Na(v)1.8 is only expressed in subsets of neurons in dorsal root ganglia (DRG) and trigeminal and nodose ganglia. We have isolated mouse partial length Na(v)1.8 cDNA clones spanning the exon 17 sequence, which have 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fe84165f3b7f900f7b3e9dcf124ecb
https://doi.org/10.1074/jbc.m401281200

p53-dependent X-ray-induced modulation of cytokine mRNA levelsin vivo

Autor: Eric G. Wright, Mark Plumb, Niall C. H. Kerr

Publikováno v: The Journal of Pathology. 186:24-30

In vitro studies have shown that ionizing radiation can cause increases in some cytokine mRNA levels and activation of the nuclear NF-kappa B and/or AP1 transcription factors which have been implicated in the transcriptional regulation of many cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac8e8b5b4ef2615d1dac62b1275e11f4
https://doi.org/10.1002/(sici)1096-9896(199809)186:1<24::aid-path139>3.0.co