Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Niall, MacQuaide"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/25ca6893fdcb43e69bb6e6d23ff57273
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where invaginations of the surface membrane (t-tubules) form functional junctions with the sarcoplasmic reticulum (SR). Within each dyad, Ca2+ entry through t-tubular
Externí odkaz:
https://doaj.org/article/3fc385dc60f141a8aa66c3423011728e
Autor:
Chien-Wen S. Kuo, Sara Dobi, Caglar Gök, Ana Da Silva Costa, Alice Main, Olivia Robertson-Gray, Daniel Baptista-Hon, Krzysztof J. Wypijewski, Hannah Costello, Tim G. Hales, Niall MacQuaide, Godfrey L. Smith, William Fuller
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Mammalian voltage-activated L-type Ca 2+ channels, such as Ca(v)1.2, control transmembrane Ca 2+ fluxes in numerous excitable tissues. Here, we report that the pore-forming α1C subunit of Ca(v)1.2 is reversibly palmitoylated in rat, rabbit, and huma
Autor:
Quentin Lachaud, Muhamad Hifzhudin Noor Aziz, Francis L Burton, Niall Macquaide, Rachel C Myles, Radostin D Simitev, Godfrey L Smith
Publikováno v:
Cardiovascular Research. 118:3112-3125
Aims Cardiac electrophysiological heterogeneity includes: (i) regional differences in action potential (AP) waveform, (ii) AP waveform differences in cells isolated from a single region, (iii) variability of the contribution of individual ion current
Publikováno v:
Frontiers Research Topics ISBN: 9782832510261
Autor:
Terje R Kolstad, Jonas van den Brink, Niall MacQuaide, Per Kristian Lunde, Michael Frisk, Jan Magnus Aronsen, Einar S Norden, Alessandro Cataliotti, Ivar Sjaastad, Ole M Sejersted, Andrew G Edwards, Glenn Terje Lines, William E Louch
Publikováno v:
eLife, Vol 7 (2018)
Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization. Using super-resolution imaging, we observe
Externí odkaz:
https://doaj.org/article/6cff6348d4064cf683d6e930c578727b
Autor:
Bracy, Fertig, Jiayue, Ling, Edgar E, Nollet, Sara, Dobi, Tara, Busiau, Kiyotake, Ishikawa, Kelly, Yamada, Ahyoung, Lee, Changwon, Kho, Lauren, Wills, Amy J, Tibbo, Mark, Scott, Kirsten, Grant, Kenneth S, Campbell, Emma J, Birks, Niall, MacQuaide, Roger, Hajjar, Godfrey L, Smith, Jolanda, van der Velden, George S, Baillie
Publikováno v:
The FEBS journal. 289(20)
Post-translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also
Autor:
Niall Macquaide, L. J Smith, Luis Alberto Gonano, Peter P. Jones, V. Staudacher, C. Thekkedam, A. B. Gamble, Asima Chakraborty, Michelle L. Munro, Angela F. Dulhunty
Publikováno v:
British Journal of Pharmacology. 176:773-786
Background and Purpose: Kinase inhibitors are a common treatment for cancer. Class I kinase inhibitors that target the ATP‐binding pocket are particularly prevalent. Many of these compounds are cardiotoxic and can cause arrhythmias. Spontaneous rel
Autor:
Charlotte Smith, Lauren Toms, George Madders, Jessica Clarke, Niall Macquaide, David A. Eisner, Andrew Trafford, Katharine Dibb
Publikováno v:
Heart Rhythm. 19:S104
Autor:
Brian O. Smith, Amy J. Tibbo, William Fuller, George S. Baillie, Caglar Gök, Aisling McFall, Niall MacQuaide, Gonzalo S. Tejeda, Ruth MacLeod, Godfrey L. Smith, Connor M. Blair, Thomas Brand, Sara Dobi
Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662d72da79fdb83266d8ecdc28d28a77
https://doi.org/10.1101/2020.09.10.290825
https://doi.org/10.1101/2020.09.10.290825