Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nia Tatsis"'
Autor:
Scott E. Hensley, Dongming Zhou, Zhi Quan Xiang, Nia Tatsis, Kimberly C. Harris-McCoy, Amaya Iparraguirre, E. John Wherry, Julie C. Fitzgerald, Shih-Wen Lin, Ang Bian, Cesar Lopez-Camacho, Arturo Reyes-Sandoval, Hildegund C. J. Ertl
CD8+ T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8+ T cells elicited by replication-defective adenovirus vectors are linked to pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589d17951e9685d524f67e1c698bdd39
https://ora.ox.ac.uk/objects/uuid:45df700e-659e-4f7d-b34e-56449c96e104
https://ora.ox.ac.uk/objects/uuid:45df700e-659e-4f7d-b34e-56449c96e104
Autor:
Aguinaldo R. Pinto, Shih W. Lin, Nia Tatsis, Wynetta Giles-Davis, Lauren J. DiMenna, Larissa H. Haut, Hildegund C. J. Ertl
Publikováno v:
European Journal of Immunology. 40:3426-3438
Most studies on E1-deleted adenovirus (Ad) vectors as vaccine carriers for antigens of HIV-1 have focused on induction of central immune responses, although stimulation of mucosal immunity at the genital tract (GT), the primary port of entry of HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0122379efbd84d843d3665b950a6b4df
https://doi.org/10.1002/eji.201040440
https://doi.org/10.1002/eji.201040440
Autor:
Nia, Tatsis, Marcio O, Lasaro, Shih-Wen, Lin, Larissa H, Haut, Zhi Q, Xiang, Dongming, Zhou, Lauren, Dimenna, Hua, Li, Ang, Bian, Sarah, Abdulla, Yan, Li, Wynetta, Giles-Davis, Jessica, Engram, Sarah J, Ratcliffe, Guido, Silvestri, Hildegund C, Ertl, Michael R, Betts
Publikováno v:
The Journal of Immunology. 182:6587-6599
In the phase IIb STEP trial an HIV-1 vaccine based on adenovirus (Ad) vectors of the human serotype 5 (AdHu5) not only failed to induce protection but also increased susceptibility to HIV-1 infection in individuals with preexisting neutralizing Abs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c29f594efe226d9bd75da8091e9efc
https://doi.org/10.4049/jimmunol.0900317
https://doi.org/10.4049/jimmunol.0900317
Autor:
Nia Tatsis, Hildegund C. J. Ertl
Publikováno v:
Molecular Therapy
Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and adaptive immune responses in mammalian hosts. Currently, adenovirus vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a9abc15f574631e01b6f03d182d5d8
The importance of ubiquitination in MHC class I-restricted Ag processing remains unclear. To address this issue, we overexpressed wild-type and dominant-negative lysineless forms of ubiquitin (Ub) in mammalian cells using an inducible vaccinia virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649998ef4597ff079221a4db527f356d
https://europepmc.org/articles/PMC3650468/
https://europepmc.org/articles/PMC3650468/
Autor:
Marcio O. Lasaro, Nia Tatsis, Hildegund C. J. Ertl, Shih-Wen Lin, Mark Drinker, Guangping Gao, Susan L. Pichla-Gollon, Scott E. Hensley, Larissa Herkenhoff-Haut, James M. Wilson, Jeffrey M. Bergelson
Publikováno v:
Journal of virology. 83(11)
A major obstacle to the use of adenovirus vectors derived from common human serotypes, such as human adenovirus 5 (AdHu5), is the high prevalence of virus-neutralizing antibodies in the human population. We previously constructed a variant of chimpan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a727ee262e408d897c06896ca35010
https://pubmed.ncbi.nlm.nih.gov/19279092
https://pubmed.ncbi.nlm.nih.gov/19279092
Autor:
Hildegund C. J. Ertl, Roselyn J. Eisenberg, Shih-Wen Lin, Marcio O. Lasaro, Gary H. Cohen, Nia Tatsis, Scott E. Hensley, J. Charles Whitbeck, John J. Rux, E. John Wherry
Interactions between the herpesvirus entry mediator (HVEM) and the B- and T-lymphocyte attenuator (BTLA) inhibit B and T cell activation. HVEM-BTLA interactions are blocked by herpes simplex virus (HSV) glycoprotein D (gD) through binding of its N-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbb058f5a6081f071f18b29a3069c6e
https://europepmc.org/articles/PMC3992986/
https://europepmc.org/articles/PMC3992986/
Recombinant adeno-associated virus (rAAV) vectors were used in human trials as carriers of vaccines for HIV-1 after encouraging preclinical results. However, the clinical trials yielded disappointing results. Here we demonstrated that in mice, rAAV v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb68118fb41314c0c3346ebe7d11d1b
https://europepmc.org/articles/PMC2078325/
https://europepmc.org/articles/PMC2078325/
Autor:
Mark B. Feinberg, Shih-Wen Lin, Kimberly C. Harris-McCoy, Nia Tatsis, David A. Garber, Hildegund C. J. Ertl
Recombinant adenovirus vectors and MVA vectors were used in prime boost vaccine regimens to address the impact of repeated immunizations on transgene product-specific CD8+ T cell frequencies, phenotypes, function, and localization. We show that a reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbefef9dca30ad2459858fe4e387103c
https://europepmc.org/articles/PMC2043483/
https://europepmc.org/articles/PMC2043483/
Autor:
Zhiquan Xiang, Scott E. Hensley, Birgit Korioth-Schmitz, Hildegund C.J. Ertl, Ann Cun, Wynetta Giles-Davis, Marcio O. Lasaro, Dongming Zhou, Norman L. Letvin, Kimberly C. McCoy, Nia Tatsis, Yan Li, Shih-Wen Lin
Publikováno v:
Journal of virology. 81(12)
In this study we compared a prime-boost regimen with two serologically distinct replication-defective adenovirus (Ad) vectors derived from chimpanzee serotypes C68 and C1 expressing Gag, Pol, gp140, and Nef of human immunodeficiency virus type 1 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8312ddcc5c34b93159f2f416c6a90fb0
https://pubmed.ncbi.nlm.nih.gov/17428852
https://pubmed.ncbi.nlm.nih.gov/17428852