Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nia Kyritsis"'
Autor:
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin consta
Externí odkaz:
https://doaj.org/article/fb9a1a28118c4b5dabf5614e2b7d2067
Autor:
Julie C. Chow, Nia Kyritsis, Micah Mills, Matthew H. Godfrey, Craig A. Harms, Paul E. Anderson, Andrew M. Shedlock
Publikováno v:
Animals, Vol 11, Iss 11, p 3013 (2021)
Background: Digital transcriptomics is rapidly emerging as a powerful new technology for modelling the environmental dynamics of the adaptive landscape in diverse lineages. This is particularly valuable in taxa such as turtles and tortoises (order Te
Externí odkaz:
https://doaj.org/article/98da6851542141429868150c97478b41
Autor:
Edward W. Dring, Jiangman Lou, Adam Yongxin Ye, Rafael Casellas, Sherry G. Lin, Hai-Qiang Dai, Kyong-Rim Kieffer-Kwon, Nia Kyritsis, Frederick W. Alt, Zhaoqing Ba, Suvi Jain
Publikováno v:
Nature
The RAG endonuclease initiates Igh locus V(D)J recombination in progenitor (pro)-B cells1. Upon binding a recombination centre-based JH, RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate Ds and assemble a DJH
Autor:
Micah Mills, Nia Kyritsis, Matthew H. Godfrey, Craig A. Harms, Andrew M. Shedlock, Paul E. Anderson, Julie C Chow
Publikováno v:
Animals, Vol 11, Iss 3013, p 3013 (2021)
Animals
Volume 11
Issue 11
Animals
Volume 11
Issue 11
Background: Digital transcriptomics is rapidly emerging as a powerful new technology for modelling the environmental dynamics of the adaptive landscape in diverse lineages. This is particularly valuable in taxa such as turtles and tortoises (order Te
Publikováno v:
Nature
Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100–200 kb downstream1. Each CH is flanked upstream by an I promoter and long repet
IgH class switch recombination (CSR) replaces Cμ constant region (CH) exons with one of six downstream CHS by joining transcription-targeted DSBs in the Cμ switch (S) region to DSBs in a downstream S region. Chromatin loop extrusion underlies funda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72d5980416b443095b1d5e9cbe05c6e0
https://doi.org/10.1101/2020.11.25.398404
https://doi.org/10.1101/2020.11.25.398404
Autor:
Jiangman Lou, Adam Yongxin Ye, Rafael Casellas, Zhaoqing Ba, Frederick W. Alt, Huan Chen, Sherry Lin, Aimee M. Chapdelaine-Williams, Hongli Hu, Cheng-Sheng Lee, Kerstin Johnson, Hai-Qiang Dai, Andrea Conte, Nicole Manfredonia, Rachael Judson, Yiwen Zhang, Nia Kyritsis
Immunoglobulin heavy chain locus (Igh) VH, D, and JHgene segments are developmentally assembled into V(D)J exons. RAG endonuclease initiates V(D)J recombination by binding a JH-recombination signal sequence (RSS) within a chromatin-based recombinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d8829bb78b6018b5b5089844f18a9d2
https://doi.org/10.1101/2020.06.30.181222
https://doi.org/10.1101/2020.06.30.181222
Autor:
Zhaoqing Ba, Andrea Conte, Huan Chen, Hongli Hu, Sherry Lin, Cheng-Sheng Lee, Frederick W. Alt, Adam Yongxin Ye, Nia Kyritsis, Jiangman Lou, Rafael Casellas, Hai-Qiang Dai, Hye Suk Yoon, Lijuan Zhao, Aimee Chapdelaine-Williams, Yiwen Zhang, Kerstin Johnson, Xuefei Zhang
Publikováno v:
Nature. 590(7845)
RAG endonuclease initiates Igh V(D)J recombination in progenitor B cells by binding a JH-recombination signal sequence (RSS) within a recombination centre (RC) and then linearly scanning upstream chromatin, presented by loop extrusion mediated by coh
Autor:
Yuxiang Zhang, Pei-Chi Wei, Anne Devorak, Frederick W. Alt, Aseda Tena, Nia Kyritsis, Jeffrey Zurita
Publikováno v:
Proc Natl Acad Sci U S A
Mild replication stress enhances appearance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs). Robust RDCs occur within genes (“RDC-genes”) that are long and have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efc5251e55ba0713c4da0bf20851f7f
https://europepmc.org/articles/PMC7229678/
https://europepmc.org/articles/PMC7229678/
Autor:
Hongli Hu, Muhammad S. Shamim, Xuefei Zhang, Zhaoqing Ba, Yu Zhang, Aviva Presser Aiden, Zhuoyi Liang, Nia Kyritsis, Jiangman Lou, Erez Lieberman Aiden, Jeffrey Zurita, Frederick W. Alt, Edward W. Dring
Publikováno v:
Nature
The RAG endonuclease initiates Igh V(D)J assembly in B cell progenitors by joining D segments to JH segments, before joining upstream VH segments to DJH intermediates1. In mouse progenitor B cells, the CTCF-binding element (CBE)-anchored chromatin lo