Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

Autor: Nia Emami-Shahri, Julie Foster, Roxana Kashani, Patrycja Gazinska, Celia Cook, Jane Sosabowski, John Maher, Sophie Papa

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice

Externí odkaz: https://doaj.org/article/0d1c57bc0c364c149307c2471f782318

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

Autor: Patrycja Gazinska, Julie Foster, Roxana Kashani, John Maher, Sophie Papa, Jane K. Sosabowski, Nia Emami-Shahri, Celia Cook

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1

The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of CD19+ B-cell malignancy has established a new therapeutic pillar of hematology–oncology. Nonetheless, formidable challenges remain for the attainment of comparabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b6f2b261b9c792a6f3c163324e18e5
https://doaj.org/article/0d1c57bc0c364c149307c2471f782318

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

Autor: Thorsten Hagemann, Maud Bossard, Frances R. Balkwill, Sergei A. Nedospasov, Juliana Candido, Natalie Cook, Nia Emami-Shahri, David A. Tuveson, Eleni Maniati

Publikováno v: Journal of Clinical Investigation. 121:4685-4699

The majority of human pancreatic cancers have activating mutations in the KRAS proto-oncogene. These mutations result in increased activity of the NF-κB pathway and the subsequent constitutive production of proinflammatory cytokines. Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe53f6d3d65cb2a4c3a707213eb2691
https://doi.org/10.1172/jci45797

Resistance--the true face of biological defiance

Autor: Nia Emami-Shahri, Thorsten Hagemann

Publikováno v: Rheumatology (Oxford, England). 51(3)

Biological therapeutics are widely used in chronic inflammatory and malignant disease. The underlying mechanisms of treatment failure for these drugs are poorly understood. Resistance to these biological agents and the further subdivision into intrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fadea4e5693696777c65a0322c50992
https://pubmed.ncbi.nlm.nih.gov/22109797

Abstract 3209: Metformin suppresses the growth and modulates the metabolic profiles of pancreatic cancer cells under hypoxia in an IKKα-dependent manner

Autor: Nia Emami-Shahri, Maud Bossard, Thorsten Hagemann, Eleni Maniati

Publikováno v: Cancer Research. 72:3209-3209

Nuclear factor-βB; (NF-κB) controls a range of genes involved in inflammation, cell survival, growth and apoptosis. The dysregulated NF-κB pathway has been found to be involved in carcinogenesis and cancer progression. An IKKα-deleted mouse pancr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::015c8573ac80ab6592a072ab17ed0b0d
https://doi.org/10.1158/1538-7445.am2012-3209