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pro vyhledávání: '"Nia Campbell"'
Autor:
Tadatoshi Sato, Shiv Verma, Christian D. Castro Andrade, Maureen Omeara, Nia Campbell, Jialiang S. Wang, Murat Cetinbas, Audrey Lang, Brandon J. Ausk, Daniel J. Brooks, Ruslan I. Sadreyev, Henry M. Kronenberg, David Lagares, Yuhei Uda, Paola Divieti Pajevic, Mary L. Bouxsein, Ted S. Gross, Marc N. Wein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific
Externí odkaz:
https://doaj.org/article/28efc06b6072451db15433775595a921
Autor:
Paola Divieti Pajevic, Ruslan I. Sadreyev, Yuhei Uda, Audrey Lang, Shiv K. Verma, Maureen J O'Meara, Jialiang S. Wang, Ted S. Gross, Nia Campbell, Henry M. Kronenberg, Mary L. Bouxsein, Tadatoshi Sato, Brandon J. Ausk, Murat Cetinbas, Christian D. Castro Andrade, Marc N. Wein, David Lagares, Daniel J. Brooks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteo