Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nhu T. Uong"'
Autor:
Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
Externí odkaz:
https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
Autor:
Harley I. Kornblum, Timothy R. Donahue, Nhu T. Uong, Julian P. Whitelegge, Peter Rix, Chloe M. Cheng, Daniel Braas, Daria Merkurjev, Soumya Poddar, Kym F. Faull, Johannes Czernin, Antoni Ribas, Joseph R. Capri, Jesse M. Zaretsky, Liu Wei, Mina Nikanjam, Thuc Le, Woosuk Kim, Harvey R. Herschman, Evan R. Abt, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Nature Communications
Nature communications, vol 8, iss 1
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kin
Autor:
Raymond M. Gipson, Timothy R. Donahue, Jason T. Lee, Harvey R. Herschman, Liu Wei, Thuc Le, Arnon Lavie, Saman Sadeghi, Michael E. Phelps, Nhu T. Uong, Woosuk Kim, Shahriar S. Yaghoubi, Jimmy Bazzy, Caius G. Radu, Evan R. Abt, Kym F. Faull, Anthony E. Cabebe, Soumya Poddar, Roger Slavik, Joseph R. Capri, Thotsophon Taechariyakul, Juno Van Valkenburgh, Wayne R. Austin, Ken Herrmann, Xuemeng Wang, Owen N. Witte, Dalton Steele, Johannes Czernin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 15
Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK have been developed and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfde460dddeac19dc63993feeae682dd
https://escholarship.org/uc/item/5df0b26k
https://escholarship.org/uc/item/5df0b26k
Autor:
Woosuk Kim, Thuc M. Le, Liu Wei, Poddar, Soumya, Bazzy, Jimmy, Xuemeng Wang, Nhu T. Uong, Abt, Evan R., Capri, Joseph R., Austin, Wayne R., Van Valkenburgh, Juno S., Steele, Dalton, Gipson, Raymond M., Slavik, Roger, Cabebe, Anthony E., Thotsophon Taechariyakul, Yaghoubi, Shahriar S., Lee, Jason T., Sadeghi, Saman, Lavie, Arnon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/12/2016, Vol. 113 Issue 15, p4027-4032, 6p