Molecular clues in the regulation of mini‐puberty involve neuronal DNA binding transcription factor NHLH2

Autor: Faruk Hadziselimovic, Gilvydas Verkauskas, Michael B. Stadler

Publikováno v: Basic and Clinical Andrology, Vol 31, Iss 1, Pp 1-13 (2021)

Résumé Le traitement par l’agoniste de l’hormone de libération des gonadotrophines (GnRHa) suite à une intervention chirurgicale pour cryptorchidie rétablit la mini-puberté par des effets endocrinologiques et transcriptionnels et prévient

Externí odkaz: https://doaj.org/article/f999125d6192483aa2904eb9e8573199

Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

Autor: Silvia Leon, Rajae Talbi, Elizabeth A McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S Carroll, Ursula B Kaiser, Carlos F Aylwin, Alejandro Lomniczi, Víctor M Navarro

Publikováno v: eLife, Vol 10 (2021)

Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that conveys essential regulatory cues for the attainment and maintenance of reproductive function. D

Externí odkaz: https://doaj.org/article/54c541bd86434a1b9376af2d8d68d363

DNA Methylation in INA, NHLH2, and THBS4 Is Associated with Metastatic Disease in Renal Cell Carcinoma

Autor: Olga Katzendorn, Inga Peters, Natalia Dubrowinskaja, Joana M. Moog, Christel Reese, Hossein Tezval, Pouriya Faraj Tabrizi, Jörg Hennenlotter, Marcel Lafos, Markus A. Kuczyk, Jürgen Serth

Publikováno v: Cancers
Cancers; Volume 14; Issue 1; Pages: 39
Cancers, Vol 14, Iss 39, p 39 (2022)

Simple Summary Early prediction of aggressive cancer using biomarkers is thought to be important for future improvements in the personalized treatment of renal cell carcinoma (RCC). Epigenetic alterations, such as DNA methylation, are promising candi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff563faa9906e4c6c3ad151314fa820
http://europepmc.org/articles/PMC8750163

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Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression

Autor: Delf-Magnus Kummerfeld, Boris V. Skryabin, Juergen Brosius, Sergey Y. Vakhrushev, Timofey S. Rozhdestvensky

Publikováno v: Kummerfeld, D-M, Skryabin, B V, Brosius, J, Vakhrushev, S Y & Rozhdestvensky, T S 2022, ' Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice : Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression ', International Journal of Molecular Sciences, vol. 23, no. 15, 8729 . https://doi.org/10.3390/ijms23158729
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8729

Prader–Willi syndrome (PWS) is a complex neurodevelopmental disorder caused by the deletion or inactivation of paternally expressed imprinted genes at the chromosomal region 15q11–q13. The PWS-critical region (PWScr) harbors tandemly repeated non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27e6fcf46e1bea17179f2112c6fd478
https://doi.org/10.3390/ijms23158729