Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review

Autor: Jinchun Wu, Yanmin Liu, Xiaojuan Wei, Xiaofei Zhang, Yi Ye, Wei Li, Xiaoling Su

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart fa

Externí odkaz: https://doaj.org/article/b1048f117f444c389e1a275775715726

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

Autor: Storch, Ursula, Forst, Anna-Lena, Pardatscher, Franziska, Erdogmus, Serap, Philipp, Maximilian, Gregoritza, Manuel, Schnitzler, Michael Mederos y, Gudermann, Thomas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jan 01. 114(1), E37-E46.

Externí odkaz: https://www.jstor.org/stable/26478790

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels

Autor: Michael Mederos y Schnitzler, Thomas Gudermann, Ursula Storch

Publikováno v: Cells, Vol 7, Iss 11, p 218 (2018)

Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accept

Externí odkaz: https://doaj.org/article/af38c09b5cce41658b4ed156a8164528

ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine

Autor: Sepers, Jorian J., Ramalho, João J., Kroll, Jason R., Schmidt, Ruben, Boxem, Mike, Sub Developmental Biology, Developmental Biology

Publikováno v: Frontiers in Cell and Developmental Biology, 10, 1. Frontiers Media S.A.
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Frontiers in Cell and Developmental Biology 10 (2022)
Frontiers in Cell and Developmental Biology, 10

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na+/H+ exchanger 3 regulating factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bec09b2015cf4c72c5583496185d0a5
https://doi.org/10.3389/fcell.2022.769862

Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma

Autor: Junqi He, Ying Yang, Duiping Feng, Junfang Zheng, Zhiqiang Peng, Lei Wang

Publikováno v: EBioMedicine
EBioMedicine, Vol 15, Iss C, Pp 62-72 (2017)

Clear cell renal cell carcinoma (ccRCC) is the most lethal neoplasm of the urologic system. Clinical therapeutic effect varies greatly between individual ccRCC patients, so there is an urgent need to develop prognostic molecular biomarkers to help cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8f64b5502a35e2b61a2a5b14ba4d22
https://doi.org/10.1016/j.ebiom.2016.12.003