Výsledky vyhledávání - "Nhan Van Tran"

Akademický článek

Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus

Autor: Gabrielle Bourgeois, Juliette Létoquart, Nhan van Tran, Marc Graille

Publikováno v: Biomolecules, Vol 7, Iss 1, p 7 (2017)

Post-transcriptional and post-translational modifications are very important for the control and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is the most widespread modification, as it is found in all domains of li

Externí odkaz: https://doaj.org/article/6c834670354347f4a4a2217ea5909dca

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CD33 ‐targeting extracellular vesicles deliver antisense oligonucleotides against FLT3‐ITD and miR ‐125b for specific treatment of acute myeloid leukaemia

Autor: Huan Chen, Migara Kavishka Jayasinghe, Eric Yew Meng Yeo, Zhiyuan Wu, Marco Pirisinu, Waqas Muhammad Usman, Thach Tuan Pham, Kah Wai Lim, Nhan Van Tran, Anskar Y. H. Leung, Xin Du, Qiaoxia Zhang, Anh Tuân Phan, Minh T. N. Le

Publikováno v: Cell Proliferation. 55

Acute Myeloid Leukaemia (AML) is the most common blood cancer in adults. Although 2 out of 3 AML patients go into total remission after chemotherapies and targeted therapies, the disease recurs in 60%-65% of younger adult patients within 3 years afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8734670e729bdb5446d54b6f6070e99
https://doi.org/10.1111/cpr.13255

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Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator

Autor: Can Wang, Nhan van Tran, Marc Graille, Vincent Guérineau, Vincent Jactel

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, pp.gkaa830. ⟨10.1093/nar/gkaa830⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (19), pp.11068-11082. ⟨10.1093/nar/gkaa830⟩
Nucleic Acids Research, 2020, 48 (19), pp.11068-11082. ⟨10.1093/nar/gkaa830⟩

tRNAs play a central role during the translation process and are heavily post-transcriptionally modified to ensure optimal and faithful mRNA decoding. These epitranscriptomics marks are added by largely conserved proteins and defects in the function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2eec04935894bfb67d6209170111e80
https://doi.org/10.1093/nar/gkaa830

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Potent and Selective Knockdown of Tyrosine Kinase 2 by Antisense Oligonucleotides

Autor: Le Tuan Anh Nguyen, Anh Tuân Phan, Kah Wai Lim, Nhan Van Tran

Publikováno v: ImmunoHorizons. 5(2)

Tyrosine kinase 2 (TYK2) is a member of the JAK family of nonreceptor tyrosine kinase, together with JAK1, JAK2, and JAK3. JAKs are important signaling mediators of many proinflammatory cytokines and represent compelling pharmacological targets for a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1527dadc32784a2650e4c802d25863c6
https://pubmed.ncbi.nlm.nih.gov/33542028

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Akademický článek

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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

Autor: Christiane Zorbas, Samie R. Jaffrey, Nathalie Ulryck, Katherine E. Bohnsack, Marc Graille, Philipp Hackert, Felix G.M. Ernst, Denis L. J. Lafontaine, Ben R Hawley, Markus T. Bohnsack, Nhan van Tran

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2019, 47 (15), pp.7719-7733. ⟨10.1093/nar/gkz619⟩
Nucleic acids research, 47 (15

N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important m6A methyltransferases have been described functionally and structurally, but the enzymes responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfed45ba4c5d626e2a904ee303136af0
https://hal-polytechnique.archives-ouvertes.fr/hal-02333696/file/Tran-NAR-2019-HsMETTL5-TRMT112.pdf

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Akademický článek

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Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

Autor: Nhan, van Tran, Leslie, Muller, Robert L, Ross, Roxane, Lestini, Juliette, Létoquart, Nathalie, Ulryck, Patrick A, Limbach, Valérie, de Crécy-Lagard, Sarah, Cianférani, Marc, Graille

Publikováno v: Nucleic acids research. 46(16)

Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6deb253f4aaf216f719272ee5d89bd2
https://pubmed.ncbi.nlm.nih.gov/30010922

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Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus

Autor: Marc Graille, Gabrielle Bourgeois, Nhan van Tran, Juliette Létoquart

Publikováno v: Biomolecules
Biomolecules, MDPI, 2017, 7 (1), pp.7. ⟨10.3390/biom7010007⟩
Biomolecules, Vol 7, Iss 1, p 7 (2017)
Biomolecules, MDPI, 2017, 7 (4), pp.7. ⟨10.3390/biom7010007⟩

International audience; Post-transcriptional and post-translational modifications are very important for the control and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is the most widespread modification, as it is fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05727d9e0703d106d18bdfbfa281c929
https://hal.archives-ouvertes.fr/hal-03295436/document

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