Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Nhan L. Tran"'
Autor:
Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110290- (2024)
Summary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in v
Externí odkaz:
https://doaj.org/article/bd022071210a4cfc9b97ed22f0917cb0
Autor:
Leland S. Hu, Fulvio D’Angelo, Taylor M. Weiskittel, Francesca P. Caruso, Shannon P. Fortin Ensign, Mylan R. Blomquist, Matthew J. Flick, Lujia Wang, Christopher P. Sereduk, Kevin Meng-Lin, Gustavo De Leon, Ashley Nespodzany, Javier C. Urcuyo, Ashlyn C Gonzales, Lee Curtin, Erika M. Lewis, Kyle W. Singleton, Timothy Dondlinger, Aliya Anil, Natenael B. Semmineh, Teresa Noviello, Reyna A. Patel, Panwen Wang, Junwen Wang, Jennifer M. Eschbacher, Andrea Hawkins-Daarud, Pamela R. Jackson, Itamar S. Grunfeld, Christian Elrod, Gina L. Mazza, Sam C. McGee, Lisa Paulson, Kamala Clark-Swanson, Yvette Lassiter-Morris, Kris A. Smith, Peter Nakaji, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Devi P. Patra, Naresh P. Patel, Mark Lyons, Matthew Neal, Kliment Donev, Maciej M. Mrugala, Alyx B. Porter, Scott C. Beeman, Todd R. Jensen, Kathleen M. Schmainda, Yuxiang Zhou, Leslie C. Baxter, Christopher L. Plaisier, Jing Li, Hu Li, Anna Lasorella, C. Chad Quarles, Kristin R. Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan L. Tran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular
Externí odkaz:
https://doaj.org/article/a2809ec273b7446289807a553cea6a7f
Autor:
Mylan R. Blomquist, Ryan Eghlimi, Angad Beniwal, Dustin Grief, David G. Nascari, Landon Inge, Christopher P. Sereduk, Serdar Tuncali, Alison Roos, Hannah Inforzato, Ritin Sharma, Patrick Pirrotte, Shwetal Mehta, Shannon P. Fortin Ensign, Joseph C. Loftus, Nhan L. Tran
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6279 (2024)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with few effective treatments. EGFR alterations, including expression of the truncated variant EGFRvIII, are among the most frequent genomic changes in these tumors. EGFRv
Externí odkaz:
https://doaj.org/article/f44d13bf32f84893b0f046234c83c2ca
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Leland S. Hu, Lujia Wang, Andrea Hawkins-Daarud, Jennifer M. Eschbacher, Kyle W. Singleton, Pamela R. Jackson, Kamala Clark-Swanson, Christopher P. Sereduk, Sen Peng, Panwen Wang, Junwen Wang, Leslie C. Baxter, Kris A. Smith, Gina L. Mazza, Ashley M. Stokes, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Alyx B. Porter, Maciej M. Mrugala, Joseph M. Hoxworth, Teresa Wu, Nhan L. Tran, Kristin R. Swanson, Jing Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Radiogenomics uses machine-learning (ML) to directly connect the morphologic and physiological appearance of tumors on clinical imaging with underlying genomic features. Despite extensive growth in the area of radiogenomics across many cance
Externí odkaz:
https://doaj.org/article/29a1d68a17774a75aedf2ebb89547a04
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 352-364 (2020)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a discouraging prognosis. Its aggressive and highly infiltrative nature renders the current standard treatment of maximal surgical resection, radiation, and che
Externí odkaz:
https://doaj.org/article/c6c50bb490a049528a65bcc4aecdb8d1
Autor:
Bethan Morris, Lee Curtin, Andrea Hawkins-Daarud, Matthew E. Hubbard, Ruman Rahman, Stuart J. Smith, Dorothee Auer, Nhan L. Tran, Leland S. Hu, Jennifer M. Eschbacher, Kris A. Smith, Ashley Stokes, Kristin R. Swanson, Markus R. Owen
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 5, Pp 4905-4941 (2020)
Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t
Externí odkaz:
https://doaj.org/article/99df14c01fe5480e95f2de48de682d3f
Autor:
Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria, Nhan L. Tran
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-11 (2019)
Abstract Background Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ
Externí odkaz:
https://doaj.org/article/11a55e0d187447f9ad9dbba577300d4d
Autor:
Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, X. Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela R. Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y. R. Agar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib,
Externí odkaz:
https://doaj.org/article/17219987055045cbbd74e20d4356a523
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f