Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Nhan L Tran"'
Autor:
Lujia Wang, Hairong Wang, Fulvio D'Angelo, Lee Curtin, Christopher P Sereduk, Gustavo De Leon, Kyle W Singleton, Javier Urcuyo, Andrea Hawkins-Daarud, Pamela R Jackson, Chandan Krishna, Richard S Zimmerman, Devi P Patra, Bernard R Bendok, Kris A Smith, Peter Nakaji, Kliment Donev, Leslie C Baxter, Maciej M Mrugała, Michele Ceccarelli, Antonio Iavarone, Kristin R Swanson, Nhan L Tran, Leland S Hu, Jing Li
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0299267 (2024)
Background and objectiveGlioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non-invasive, M
Externí odkaz:
https://doaj.org/article/b57d4faef51a40fca14cffc4c306cabd
Autor:
Javier C Urcuyo, Lee Curtin, Jazlynn M Langworthy, Gustavo De Leon, Barrett Anderies, Kyle W Singleton, Andrea Hawkins-Daarud, Pamela R Jackson, Kamila M Bond, Sara Ranjbar, Yvette Lassiter-Morris, Kamala R Clark-Swanson, Lisa E Paulson, Chris Sereduk, Maciej M Mrugala, Alyx B Porter, Leslie Baxter, Marcela Salomao, Kliment Donev, Miles Hudson, Jenna Meyer, Qazi Zeeshan, Mithun Sattur, Devi P Patra, Breck A Jones, Rudy J Rahme, Matthew T Neal, Naresh Patel, Pelagia Kouloumberis, Ali H Turkmani, Mark Lyons, Chandan Krishna, Richard S Zimmerman, Bernard R Bendok, Nhan L Tran, Leland S Hu, Kristin R Swanson
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0287767 (2023)
Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and underlying bi
Externí odkaz:
https://doaj.org/article/9e0a2b9676eb4c9582d28ead00177ffa
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 83-83 (2022)
OBJECTIVES/GOALS: The goal of this study is to evaluate the role of WNT5A and WNT5a-AS1 in sex-differences of GBM progression. In our preliminary studies, we found that a long non-coding RNA WNT5A-AS1 is overexpressed in male GBM patients. We also fo
Externí odkaz:
https://doaj.org/article/26d373e10fa74e16b57f440cce099798
Autor:
Bodour Salhia, Jeff Kiefer, Julianna T D Ross, Raghu Metapally, Rae Anne Martinez, Kyle N Johnson, Danielle M DiPerna, Kimberly M Paquette, Sungwon Jung, Sara Nasser, Garrick Wallstrom, Waibhav Tembe, Angela Baker, John Carpten, Jim Resau, Timothy Ryken, Zita Sibenaller, Emanuel F Petricoin, Lance A Liotta, Ramesh K Ramanathan, Michael E Berens, Nhan L Tran
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85448 (2014)
The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer brain metastasis. We p
Externí odkaz:
https://doaj.org/article/d0d4b9ecba9945928518ecf1842ed18a
Autor:
Harshil D Dhruv, Wendy S McDonough Winslow, Brock Armstrong, Serdar Tuncali, Jenny Eschbacher, Kerri Kislin, Joseph C Loftus, Nhan L Tran, Michael E Berens
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72134 (2013)
Histology of malignant glioma depicts dense proliferative areas rich in angiogenesis as well as dissemination of neoplastic cells into adjacent brain tissue. Although the mechanisms that trigger transition from proliferative to invasive phenotypes ar
Externí odkaz:
https://doaj.org/article/d802163ee4f446029cf93a0317227cdf
Autor:
Joseph C Loftus, Julianna T D Ross, Kimberly M Paquette, Vincent M Paulino, Sara Nasser, Zhongbo Yang, Jean Kloss, Seungchan Kim, Michael E Berens, Nhan L Tran
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39818 (2012)
Glioblastoma (GB) is the most common and lethal type of primary brain tumor. Clinical outcome remains poor and is essentially palliative due to the highly invasive nature of the disease. A more thorough understanding of the molecular mechanisms that
Externí odkaz:
https://doaj.org/article/5c2fc83f6ae240189afe0f481bb5f80e
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Leland S. Hu, Lujia Wang, Andrea Hawkins-Daarud, Jennifer M. Eschbacher, Kyle W. Singleton, Pamela R. Jackson, Kamala Clark-Swanson, Christopher P. Sereduk, Sen Peng, Panwen Wang, Junwen Wang, Leslie C. Baxter, Kris A. Smith, Gina L. Mazza, Ashley M. Stokes, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Alyx B. Porter, Maciej M. Mrugala, Joseph M. Hoxworth, Teresa Wu, Nhan L. Tran, Kristin R. Swanson, Jing Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Radiogenomics uses machine-learning (ML) to directly connect the morphologic and physiological appearance of tumors on clinical imaging with underlying genomic features. Despite extensive growth in the area of radiogenomics across many cance
Externí odkaz:
https://doaj.org/article/29a1d68a17774a75aedf2ebb89547a04
Autor:
Bethan Morris, Lee Curtin, Andrea Hawkins-Daarud, Matthew E. Hubbard, Ruman Rahman, Stuart J. Smith, Dorothee Auer, Nhan L. Tran, Leland S. Hu, Jennifer M. Eschbacher, Kris A. Smith, Ashley Stokes, Kristin R. Swanson, Markus R. Owen
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 5, Pp 4905-4941 (2020)
Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t
Externí odkaz:
https://doaj.org/article/99df14c01fe5480e95f2de48de682d3f
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f