Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

Autor: Barnaby Flower, Le Manh Hung, Leanne Mccabe, M Azim Ansari, Chau Le Ngoc, Thu Vo Thi, Hang Vu Thi Kim, Phuong Nguyen Thi Ngoc, Le Thanh Phuong, Vo Minh Quang, Thuan Dang Trong, Thao Le Thi, Tran Nguyen Bao, Cherry Kingsley, David Smith, Richard M Hoglund, Joel Tarning, Evelyne Kestelyn, Sarah L Pett, Rogier van Doorn, Jennifer Ilo Van Nuil, Hugo Turner, Guy E Thwaites, Eleanor Barnes, Motiur Rahman, Ann Sarah Walker, Jeremy N Day, Nguyen VV Chau, Graham S Cooke

Publikováno v: eLife, Vol 12 (2023)

Background: World Health Organization has called for research into predictive factors for selecting persons who could be successfully treated with shorter durations of direct-acting antiviral (DAA) therapy for hepatitis C. We evaluated early virologi

Externí odkaz: https://doaj.org/article/3ba314b4797945c5a31bd2030707b7a6

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Autor: Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites

Publikováno v: eLife, Vol 7 (2018)

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammat

Externí odkaz: https://doaj.org/article/ca41dbbd23d545c7a32fcb37b31b939e

Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

Autor: Nathalie Acestor, Christine Halleux, Dong Thi Hoai Tam, Ngoun Chanpheaktra, Lucy Chai See Lum, Kien Duong Thi Hue, Ronald B. Geskus, Bridget Wills, Nguyet Minh Nguyen, Derek Bell, Nguyen Vv Chau, Huynh Thi Le Duyen, Nguyen Lam Vuong, Damien Keng Yen Ming, Cameron P. Simmons, Kerstin D Rosenberger, Phung Khanh Lam, Sophie Yacoub, Ernesto Pleités, Piero Olliaro, Thomas Jaenisch

Publikováno v: eLife, Vol 10 (2021)
eLife

Background:Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f566663df1954fb4bf9a99dce69380da
https://elifesciences.org/articles/67460

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Autor: Ho Dt Nghia, Jesmond Dalli, Le Tp Thao, Do Dang Anh Thu, A Dorothee Heemskerk, Ronald B. Geskus, Nguyen Th Mai, Nguyen Tt Thuong, Guy E. Thwaites, Jeremy N. Day, Laura Merson, Nguyen T. Hang, Romain A. Colas, David Summers, Nguyen Hh Hanh, Nguyen Hoan Phu, Lucy Ly, Nicholas Dobbs, Evelyne Kestelyn, Marcel Wolbers, Nguyen Vv Chau

Publikováno v: eLife
eLife, Vol 7 (2018)
Mai, N T, Dobbs, N, Phu, N H, Colas, R A, Thao, L T, Thuong, N T, Nghia, H D, Hanh, N H, Hang, N T, Heemskerk, A D, Day, J N, Ly, L, Thu, D DA, Merson, L, Kestelyn, E, Wolbers, M, Geskus, R, Summers, D, Chau, N V, Dalli, J & Thwaites, G E 2018, ' A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults ', eLIFE, vol. 7 . https://doi.org/10.7554/eLife.33478
eLife, 7. eLife Sciences Publications Limited
Mai, N T, Dobbs, N, Phu, N H, Colas, R A, Thao, L T, Thuong, N T, Nghia, H D, Hanh, N H, Hang, N T, Heemskerk, A D, Day, J N, Ly, L, Thu, D D A, Merson, L, Kestelyn, E, Wolbers, M, Geskus, R, Summers, D, Chau, N V, Dalli, J & Thwaites, G E 2018, ' A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults ', eLife, vol. 7 . https://doi.org/10.7554/eLife.33478

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd49c3f19d010634111acedac7aa67be
https://doi.org/10.7554/elife.33478