Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nguyen T B, Nguyen"'
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
In p53-deficient colorectal cancer organoids, 5-fluorouracil induces pyrimidine imbalance, which causes DNA damage and cell death. Rewiring glucose metabolism through PDK inhibition by DCA enhances 5-FU toxicity in glycolytic p53-deficient organoids.
Externí odkaz:
https://doaj.org/article/c8a2e24e3c664ab7b22d3021e93d4b64
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, 5(1). Nature Research
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c6e385e7fdeaa49121f97775fe202
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
Autor:
Marlies C, Ludikhuize, Sira, Gevers, Nguyen T B, Nguyen, Maaike, Meerlo, S Khadijeh Shafiei, Roudbari, M Can, Gulersonmez, Edwin C A, Stigter, Jarno, Drost, Hans, Clevers, Boudewijn M T, Burgering, Maria J, Rodríguez Colman
Publikováno v:
Communications biology. 5(1)
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3979969f46d2d108887abde4150a538
https://pubmed.ncbi.nlm.nih.gov/36316440
https://pubmed.ncbi.nlm.nih.gov/36316440