Unbiased Screens Show CD8 ⁺ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.

Autor: Ferretti AP; TScan Therapeutics, Waltham, MA 02451, USA., Kula T; TScan Therapeutics, Waltham, MA 02451, USA., Wang Y; TScan Therapeutics, Waltham, MA 02451, USA., Nguyen DMV; TScan Therapeutics, Waltham, MA 02451, USA., Weinheimer A; TScan Therapeutics, Waltham, MA 02451, USA., Dunlap GS; TScan Therapeutics, Waltham, MA 02451, USA., Xu Q; TScan Therapeutics, Waltham, MA 02451, USA., Nabilsi N; TScan Therapeutics, Waltham, MA 02451, USA., Perullo CR; TScan Therapeutics, Waltham, MA 02451, USA., Cristofaro AW; TScan Therapeutics, Waltham, MA 02451, USA., Whitton HJ; TScan Therapeutics, Waltham, MA 02451, USA., Virbasius A; TScan Therapeutics, Waltham, MA 02451, USA., Olivier KJ Jr; TScan Therapeutics, Waltham, MA 02451, USA., Buckner LR; Ochsner Medical Center, New Orleans, LA 70121, USA., Alistar AT; Atlantic Health System, Morristown, NJ 07960, USA., Whitman ED; Atlantic Health System, Morristown, NJ 07960, USA., Bertino SA; TScan Therapeutics, Waltham, MA 02451, USA., Chattopadhyay S; TScan Therapeutics, Waltham, MA 02451, USA., MacBeath G; TScan Therapeutics, Waltham, MA 02451, USA. Electronic address: gmacbeath@tscan.com.

Publikováno v: Immunity [Immunity] 2020 Nov 17; Vol. 53 (5), pp. 1095-1107.e3. Date of Electronic Publication: 2020 Oct 20.

SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies.

Autor: Cioffi, Victor Bolsanelli¹ (AUTHOR), de Castro-Amarante, Maria Fernanda² (AUTHOR), Lulla, Aleksei³ (AUTHOR), Andreata-Santos, Robert² (AUTHOR), Cruz, Mario Costa⁴ (AUTHOR), Moreno, Ana Carolina Ramos^2,5 (AUTHOR), de Oliveira Silva, Mariângela⁶ (AUTHOR), de Miranda Peres, Bianca⁶ (AUTHOR), de Freitas Junior, Lucio Holanda Gondim⁶ (AUTHOR), Moraes, Carolina Borsoi⁶ (AUTHOR), Durigon, Edison Luiz^7,8 (AUTHOR), Gordon, Nicola Coker³ (AUTHOR), Hyvönen, Marko³ (AUTHOR), de Souza Ferreira, Luís Carlos^2,8 (AUTHOR), Balan, Andrea¹ (AUTHOR) abalan@usp.br

Publikováno v: Scientific Reports. 10/5/2023, Vol. 13 Issue 1, p1-12. 12p.

Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2.

Autor: Becerra-Artiles, Aniuska¹ (AUTHOR), Nanaware, Padma P.¹ (AUTHOR), Muneeruddin, Khaja² (AUTHOR), Weaver, Grant C.¹ (AUTHOR), Shaffer, Scott A.^2,3 (AUTHOR), Calvo-Calle, J. Mauricio¹ (AUTHOR), Stern, Lawrence J.^1,3 (AUTHOR) lawrence.stern@umassmed.edu

Publikováno v: PLoS Pathogens. 7/27/2023, Vol. 19 Issue 7, p1-32. 32p.

Molecular mimicry of SARS-COV-2 antigens as a possible natural anti-cancer preventive immunization.

Autor: Ragone, Concetta, Mauriello, Angela, Cavalluzzo, Beatrice, Cavalcanti, Ernesta, Russo, Luigi, Manolio, Carmen, Mangano, Simona, Cembrola, Biancamaria, Tagliamonte, Maria, Buonaguro, Luigi

Publikováno v: Frontiers in Immunology; 2024, p1-21, 21p

FASTMAP--a flexible and scalable immunopeptidomics pipeline for HLA- and antigen-specific T-cell epitope mapping based on artificial antigen-presenting cells.

Autor: Weisbrod, Luisa, Capriotti, Luigi, Hofmann, Marco, Spieler, Valerie, Dersch, Herbert, Voedisch, Bernd, Schmidt, Peter, Knake, Susanne

Publikováno v: Frontiers in Immunology; 2024, p01-19, 19p