Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Nguyen C. Pham"'
Autor:
Henri Leinonen, Nguyen C Pham, Taylor Boyd, Johanes Santoso, Krzysztof Palczewski, Frans Vinberg
Publikováno v:
eLife, Vol 9 (2020)
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizin
Externí odkaz:
https://doaj.org/article/cf20828d37544622bc3ae6e18e0ed555
Autor:
Brett P. Monia, Steven G. Hughes, Marshelle S. Warren, Jason D. Ferrone, Gwendolyn E. Kaeser, Eugene Schneider, A. Robert MacLeod, Nicholas J. Viney, Brenda F. Baker, Alexey S. Revenko, Frederick Derosier, Gourab Bhattacharjee, Nguyen C. Pham, Thomas A. Zanardi
Publikováno v:
Nucleic Acid Therapeutics. 29:82-91
Kallikrein is the key contact system mediator responsible for the conversion of high-molecular-weight kininogen into the inflammatory vasodilator peptide bradykinin, a process regulated by C1-esterase inhibitor (C1-INH). In hereditary angioedema (HAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969051625899292f6463ecc560f45748
https://doi.org/10.1089/nat.2018.0754
https://doi.org/10.1089/nat.2018.0754
Autor:
Martin Gajdošík, Julia K. Overman, Erin S. Morgan, Richard S. Geary, Li-Jung Tai, Shiangtung W. Jung, Lynnetta Watts, Brenda F. Baker, Martin Krššák, Michael Krebs, Sanjay Bhanot, Anne Smith, Nguyen C. Pham
Publikováno v:
Diabetes Care. 42:585-593
OBJECTIVE To evaluate the safety and efficacy of IONIS-GCGRRx, a 2′-O-methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ebb99ae677c4e5967eefb37b6fa2fe
https://doi.org/10.2337/dc18-1343
https://doi.org/10.2337/dc18-1343
Autor:
Frans Vinberg, Henri Leinonen, Johanes Santoso, Nguyen C. Pham, Taylor Boyd, Krzysztof Palczewski
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8b95543cec8a8291eea9a1221a70a5
https://doi.org/10.7554/elife.59422
https://doi.org/10.7554/elife.59422
Autor:
Taylor Boyd, Nguyen C. Pham, Henri Leinonen, Frans Vinberg, Johanes Santoso, Krzysztof Palczewski
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::749df49a180da89e547ebc64483ad108
https://doi.org/10.1101/2020.05.28.121673
https://doi.org/10.1101/2020.05.28.121673
Autor:
Lynnetta Watts, Erin S. Morgan, Nguyen C. Pham, Richard S. Geary, Sanjay Bhanot, Andres DiGenio, Shiangtung W. Jung, Brenda F. Baker
Publikováno v:
Diabetes Care. 41:807-814
OBJECTIVE To evaluate safety and efficacy of IONIS-PTP-1BRx, a second-generation 2′-O-methoxyethyl antisense inhibitor of protein tyrosine phosphatase 1B, as add-on therapy in overweight patients with type 2 diabetes inadequately controlled with me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de1a71e83819b1a2b2fda5df493cbae
https://doi.org/10.2337/dc17-2132
https://doi.org/10.2337/dc17-2132
Autor:
T Jesse Kwoh, Sanjay Bhanot, Nguyen C. Pham, Brenda F. Baker, Richard S. Geary, Danlin Cai, Sotirios Tsimikas, Stanley T. Crooke, Steven G. Hughes
Publikováno v:
Nucleic Acid Therapeutics
Nucleic acid therapeutics, vol 28, iss 1
Nucleic acid therapeutics, vol 28, iss 1
Systemically administered 2'-O-methoxyethyl (2'MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2'MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f473dee670b36e966c426417ed8afc
http://europepmc.org/articles/PMC5790433
http://europepmc.org/articles/PMC5790433
Autor:
Jason D, Ferrone, Gourab, Bhattacharjee, Alexey S, Revenko, Thomas A, Zanardi, Marshelle S, Warren, Frederick J, Derosier, Nicholas J, Viney, Nguyen C, Pham, Gwendolyn E, Kaeser, Brenda F, Baker, Eugene, Schneider, Steven G, Hughes, Brett P, Monia, A Robert, MacLeod
Publikováno v:
Nucleic Acid Therapeutics
Kallikrein is the key contact system mediator responsible for the conversion of high-molecular-weight kininogen into the inflammatory vasodilator peptide bradykinin, a process regulated by C1-esterase inhibitor (C1-INH). In hereditary angioedema (HAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b54043aab3722f9df30ce8645b4f7232
https://pubmed.ncbi.nlm.nih.gov/30817230
https://pubmed.ncbi.nlm.nih.gov/30817230
Autor:
Erin S, Morgan, Li-Jung, Tai, Nguyen C, Pham, Julia K, Overman, Lynnetta M, Watts, Anne, Smith, Shiangtung W, Jung, Martin, Gajdošík, Martin, Krššák, Michael, Krebs, Richard S, Geary, Brenda F, Baker, Sanjay, Bhanot
Publikováno v:
Diabetes care. 42(4)
To evaluate the safety and efficacy of IONIS-GCGRIn three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGRSignificant reductions in HbAIONIS-GCGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdfee04115b485f4ba28d2de7675a073
https://pubmed.ncbi.nlm.nih.gov/30765435
https://pubmed.ncbi.nlm.nih.gov/30765435