OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Autor: Panagiotou, Styliani, Tan, Kia Wee, Nguyen, Phuoc My, Müller, Andreas, Oqua, Affiong Ika, Tomas, Alejandra, Wendt, Anna, Eliasson, Lena, Tengholm, Anders, Solimena, Michele, Idevall-Hagren, Olof

Publikováno v: In Cell Reports 23 April 2024 43(4)

Phosphoinositides control insulin secretion through multiple routes

Autor: Nguyen, Phuoc My

Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bf8e5ad4a50bbe8762f7d7876b088a7a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429254

The PI(4)P phosphatase Sac2 controls insulin granule docking and release.

Autor: Nguyen PM; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Gandasi NR; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Xie B; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Sugahara S; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.; Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan., Xu Y; Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China., Idevall-Hagren O; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden olof.idevall@mcb.uu.se.

Publikováno v: The Journal of cell biology [J Cell Biol] 2019 Nov 04; Vol. 218 (11), pp. 3714-3729. Date of Electronic Publication: 2019 Sep 18.