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Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers.

Autor: Miao Y; Department of Medicinal Chemistry and Molecular Pharmacology and., Bai Y; Department of Medicinal Chemistry and Molecular Pharmacology and., Miao J; Department of Medicinal Chemistry and Molecular Pharmacology and., Murray AA; Department of Medicinal Chemistry and Molecular Pharmacology and., Lin J; Department of Medicinal Chemistry and Molecular Pharmacology and., Dong J; Department of Medicinal Chemistry and Molecular Pharmacology and., Qu Z; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Zhang RY; Department of Medicinal Chemistry and Molecular Pharmacology and., Nguyen QD; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Wang S; Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Yu J; Department of Medicinal Chemistry and Molecular Pharmacology and., Nguele Meke F; Department of Medicinal Chemistry and Molecular Pharmacology and., Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology and.; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.; Institute for Cancer Research and.; Institute for Drug Discovery, Purdue University, West Lafayette, Indiana, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jun 06; Vol. 134 (15). Date of Electronic Publication: 2024 Jun 06.

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.

Autor: Chen H; Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China.; Department of Medicine, Northwestern University, Chicago, Illinois.; School of Medicine, Chongqing University, Chongqing, China., Bai Y; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana., Kobayashi M; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Xiao S; Department of Medicine, Northwestern University, Chicago, Illinois., Barajas S; Department of Medicine, Northwestern University, Chicago, Illinois.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Cai W; Department of Medicine, Northwestern University, Chicago, Illinois.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Chen S; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Miao J; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana., Nguele Meke F; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana., Yao C; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China., Yang Y; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Medical Genetics, Peking University Health Science Center, Beijing, China., Strube K; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Satchivi O; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Sun J; Division of Translational Cancer Research and Lund Stem Cell Center, Lund University, Lund, Sweden., Rönnstrand L; Division of Translational Cancer Research and Lund Stem Cell Center, Lund University, Lund, Sweden., Croop JM; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana., Boswell HS; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Jia Y; Department of Pharmacology, Northwestern University, Chicago, Illinois., Liu H; Department of Pharmacology, Northwestern University, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois., Li LS; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.; Department of Pediatrics, Northwestern University, Chicago, Illinois., Altman JK; Department of Medicine, Northwestern University, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois., Eklund EA; Department of Medicine, Northwestern University, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.; Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois., Sukhanova M; Department of Pathology, Northwestern University, Chicago, Illinois., Ji P; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.; Department of Pathology, Northwestern University, Chicago, Illinois., Tong W; Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania., Band H; Department of Genetics, University of Nebraska Medical Center, Omaha, Nebraska., Huang DT; Cancer Research UK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Platanias LC; Department of Medicine, Northwestern University, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.; Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois., Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana., Liu Y; Department of Medicine, Northwestern University, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2024 Jan 02; Vol. 22 (1), pp. 94-103.

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.

Autor: Li Q; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907., Bai Y; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907., Lyle LT; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907.; Center for Cancer Research, Purdue University, West Lafayette, IN 47907., Yu G; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907., Amarasinghe O; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Nguele Meke F; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907., Carlock C; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907., Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907; zhang-zy@purdue.edu.; Center for Cancer Research, Purdue University, West Lafayette, IN 47907.; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20538-20548. Date of Electronic Publication: 2020 Aug 11.