Poor association between 13-valent pneumococcal conjugate vaccine-induced serum and mucosal antibody responses with experimental Streptococcus pneumoniae serotype 6B colonisation

Autor: Tembo, G., Mayuni, M., Kamng'ona, R., Chimgoneko, L., Chiwala, G., Sichone, S., Galafa, B., Thole, F., Mkandawire, C., Chirwa, A.E., Nsomba, E., Nkhoma, V., Ngoliwa, C., Toto, N., Makhaza, L., Muyaya, A., Kudowa, E., Henrion, M.Y.R., Dula, D., Morton, B., Chikaonda, T., Gordon, S.B., Jambo, K.C.

Publikováno v: In Vaccine 30 April 2024 42(12):2975-2982

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Natural carriage of Streptococcus pneumoniae is associated with increased experimental pneumococcal carriage but reduced conjugate vaccine efficacy in a human challenge model.

Autor: Galafa B; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Chikaonda T; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Kudowa E; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Sichone S; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Sibale L; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Thole F; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Mkandawire C; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Dula D; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Nsomba E; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Tembo G; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Chaponda M; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Chirwa AE; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Nkhoma V; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Ngoliwa C; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Kamng'ona R; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Toto N; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Makhaza L; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Muyaya A; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Howard A; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Nyazika TK; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Ndaferankhande J; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Chimgoneko L; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Banda NPK; Queen Elizabeth Central Hospital, Blantyre, Malawi.; Kamuzu University of Health Sciences, Blantyre, Malawi., Chiwala G; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Rylance J; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Ferreira D; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Department of Paediatrics, University of Oxford, United Kingdom., Jambo KC; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Morton B; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom., Henrion MYR; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Gordon SB; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10.