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Akademický článek

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

Autor: Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown

Publikováno v: eLife, Vol 8 (2019)

Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2α preference for phosphatidy

Externí odkaz: https://doaj.org/article/af6a1b2fae9e4f1fa435261f48886fe1

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Data from Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function

Autor: Charles E. Chalfant, H. Patrick MacKnight, Daniel J. Stephenson, Minjung Kim, Ngoc T. Vu

Ceramide kinase (CERK) is the mammalian lipid kinase from which the bioactive sphingolipid, ceramide-1-phosphate (C1P), is derived. CERK has been implicated in several promalignant phenotypes with little known as to mechanistic underpinnings. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eeb8a90499c5fe38d293a247c3de34
https://doi.org/10.1158/1541-7786.c.6545652

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Data from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

Autor: Charles E. Chalfant, Sungjune Kim, Raghavendra Pillappa, Cora Uram-Tuculescu, Min-Hsuan Wang, Gamze B. Bulut, Xue Wang, Ngoc T. Vu, Minjung Kim

Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumors and dir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc653d9d09485357a5cfefd407e44351
https://doi.org/10.1158/1541-7786.c.6545402.v1

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Supplemental Figures and Tables from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis

Autor: Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu

Supplemental Figure 1: Larger legend table for symbols in fig 1A. Supplemental Figure 2: The expression of BIRC5, CDKN1A, CXCL1 and IER3 correlates with expression of C9b, but not C9a, in human NSCLC tissues. Supplemental Figure 3: Down-regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d97f19a24807c63fe903c538c9bbdd
https://doi.org/10.1158/0008-5472.22408449

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Data from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis

Autor: Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu

Alternate RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b). C9b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non–small cell lung cancer (NSCLC) cells. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f32dd64b0d0a2bcb04bee364bc855f5
https://doi.org/10.1158/0008-5472.c.6507537

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