Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Ngiap-Kie Lim"'
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Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes
Autor: Song Qiuling, Wenxue Wu, Jie Yan, Shinya Iimura, Mark S. Bednarz, Dai Kuangchu, Matthew Mangzhu Zhao, Haiming Zhang, Xiaodong Gu, Youchu Wang, Ngiap-Kie Lim
Publikováno v: Organic Process Research & Development. 24:2689-2701
The development of an efficient manufacturing process for sotagliflozin (LX4211), a dual inhibitor of sodium–glucose cotransporter-1/2 (SGLT-1/2) for the treatment of diabetes, is described. Sotagl...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c3755ff6820ddf3fa9552ad3ec4a108
https://doi.org/10.1021/acs.oprd.0c00359
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6
Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1
Autor: Nicholas A. White, Francis Gosselin, Ngiap-Kie Lim, William A. Nack, Paul D. O’Shea, Kyle Clagg, Haiming Zhang, Lauren E. Sirois
Publikováno v: Organic Process Research & Development. 24:1690-1699
18F-GTP1 is a deuterated small molecule positron emission tomography (PET) imaging agent used to visualize tau tangles in Alzheimer’s disease patients. The first-generation synthesis of 18F-GTP1’s ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d69f459d428926c709f744fa4a1460ee
https://doi.org/10.1021/acs.oprd.0c00301
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7
Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome
Autor: Matthew M. Zhao, Wenxue Wu, Haiming Zhang, Mark S. Bednarz, Ramanaiah C. Kanamarlapudi, Shinya Iimura, Ngiap-Kie Lim, Jie Yan
Publikováno v: Organic Process Research & Development. 24:261-273
Two process routes for LX1031, a tryptophan hydroxylase inhibitor for the treatment of irritable bowel syndrome, were developed. They shared the same left-hand and right-hand starting materials as ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c490c1ef3a7e2ca8f4679b286d08b19a
https://doi.org/10.1021/acs.oprd.9b00520
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8
Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3–sp2 Suzuki Coupling of a Benzyl Carbonate
Autor: Wenxue Wu, Lauren E. Sirois, Bryce Alden Harrison, Ngiap-Kie Lim, Matthew Mangzhu Zhao, Mark S. Bednarz
Publikováno v: Organic Process Research & Development. 23:45-61
Process development for the synthesis of a locally acting sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, LX2761, a drug candidate for the treatment of diabetes mellitus, is described. ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6520429d94d058e46a42dac21dd4e6
https://doi.org/10.1021/acs.oprd.8b00325
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9
Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853
Autor: David Linder, Francis Gosselin, Philippe James, Remy Angelaud, Ngiap-Kie Lim, Danial Beaudry, Theresa Cravillion, Haiming Zhang, Jessica L. Defreese, Sushant Malhotra, Chong Han, Qingping Tian, Alec Fettes
Publikováno v: Organic Process Research & Development. 22:978-990
Efforts toward the process development of reversible Bruton’s tyrosine kinase (BTK) inhibitor GDC-0853 (1) are described. A practical synthesis of GDC-0853 was accomplished via a key highly regioselective Pd-catalyzed C–N coupling of tricyclic la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2e2b771a677f914a3b28c27d233a43d
https://doi.org/10.1021/acs.oprd.8b00134
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