Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.

Autor: Lui KN; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR., Li Z; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR., Lai FP; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR., Lau ST; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR., Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR. Electronic address: engan@hku.hk.

Publikováno v: Stem cell reports [Stem Cell Reports] 2023 Jul 11; Vol. 18 (7), pp. 1500-1515. Date of Electronic Publication: 2023 Jun 22.

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease.

Autor: Wang Y; Department of Surgery, The University of Hong Kong, Hong Kong SAR, China., Mak TSH; Fano Labs, Hong Kong SAR, China., Dattani S; Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Garcia-Barcelo MM; Department of Surgery, The University of Hong Kong, Hong Kong SAR, China., Fu AX; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Yip KY; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Ngan ES; Department of Surgery, The University of Hong Kong, Hong Kong SAR, China., Tam PK; Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.; Dr Li Dak-Sum Research Center, The University of Hong Kong-Karolinska Institute Collaboration in Regenerative Medicine, Hong Kong SAR, China.; Faculty of Medicine, Macau University of Science and Technology, Macao, China., Tang CS; Department of Surgery, The University of Hong Kong, Hong Kong SAR, China. claratang@hku.hk.; Dr Li Dak-Sum Research Center, The University of Hong Kong-Karolinska Institute Collaboration in Regenerative Medicine, Hong Kong SAR, China. claratang@hku.hk., Sham PC; Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China. pcsham@hku.hk.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China. pcsham@hku.hk.

Publikováno v: Scientific reports [Sci Rep] 2022 Nov 28; Vol. 12 (1), pp. 20423. Date of Electronic Publication: 2022 Nov 28.

Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression.

Autor: Zhou L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China., Yu KH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, China., Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China., Zhang Z; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Chan CH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Loong JH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Che N; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Yu HJ; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Tan KV; Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China., Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Ho JW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China stefma@hku.hk jwkho@hku.hk.; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, China., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China stefma@hku.hk jwkho@hku.hk.; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China.

Publikováno v: Gut [Gut] 2022 Aug; Vol. 71 (8), pp. 1656-1668. Date of Electronic Publication: 2021 Sep 29.

BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids.

Autor: Luo J; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China., Zou H; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China., Guo Y; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China., Huang K; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China., Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong. engan@hku.hk., Li P; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, Guangdong, People's Republic of China. lipeng56@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China. lipeng56@mail.sysu.edu.cn.

Publikováno v: Cell death discovery [Cell Death Discov] 2022 Feb 02; Vol. 8 (1), pp. 47. Date of Electronic Publication: 2022 Feb 02.

Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease.

Autor: Fu AX; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong., Lui KN; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Tang CS; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong., Ng RK; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lai FP; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong., Lau ST; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong., Li Z; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Garcia-Barcelo MM; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Sham PC; Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Tam PK; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Yip KY; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong.; Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong.

Publikováno v: Genome research [Genome Res] 2020 Nov; Vol. 30 (11), pp. 1618-1632. Date of Electronic Publication: 2020 Sep 18.