Evaluating the Utility of the MSTI Assay in Predicting Compound Promiscuity and Cytotoxicity.

Autor: Kruger L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Ngan DK; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Xu T; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Zhang L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Xia M; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Simeonov A; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Huang R; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2024 Oct 21; Vol. 37 (10), pp. 1691-1697. Date of Electronic Publication: 2024 Sep 10.

Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.

Autor: Yasgar A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Bougie D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Eastman RT; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Itkin M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Kouznetsova J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Lynch C; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., McKnight C; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Miller M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Ngan DK; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Peryea T; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Shah P; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Shinn P; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Xia M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Zakharov AV; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Apr 14; Vol. 6 (5), pp. 683-701. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023).

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.

Autor: Ye L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Ngan DK; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Xu T; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Liu Z; National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), Jefferson, AR 72079, USA., Zhao J; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Sakamuru S; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Zhang L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Zhao T; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Xia M; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Simeonov A; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Huang R; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA. Electronic address: huangru@mail.nih.gov.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Nov 01; Vol. 454, pp. 116250. Date of Electronic Publication: 2022 Sep 20.

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics.

Autor: Zhu H; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Chen CZ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Sakamuru S; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Zhao J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Ngan DK; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Simeonov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Hall MD; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Xia M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Zheng W; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA., Huang R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), DPI/NCATS, 9800 Medical Center Drive, Rockville, MD, 20850, USA. huangru@mail.nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2021 Mar 24; Vol. 11 (1), pp. 6725. Date of Electronic Publication: 2021 Mar 24.

Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays.

Autor: Ngan DK; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States., Ye L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States., Wu L; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States., Xia M; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States., Rossoshek A; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States., Simeonov A; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States., Huang R; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, United States.

Publikováno v: Frontiers in big data [Front Big Data] 2019 Dec 13; Vol. 2, pp. 50. Date of Electronic Publication: 2019 Dec 13 (Print Publication: 2019).