Výsledky vyhledávání - "Ngan B. Phung"

P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

Autor: Kenneth A. Jacobson, Fatma Mufti, Ngan B. Phung, Luigino Antonio Giancotti, Daniela Salvemini, Young-Hwan Jung, Jinha Yu, Zhoumou Chen

Publikováno v: ACS Medicinal Chemistry Letters. 11:1281-1286

Eight P2Y14R antagonists, including three newly synthesized analogues, containing a naphthalene or phenyl-triazolyl scaffold were compared in a mouse model of chronic neuropathic pain (sciatic constriction). P2Y14R antagonists rapidly (≤30 min) rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5294955a197573842d2dc091376c94e0
https://doi.org/10.1021/acsmedchemlett.0c00115

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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist

Autor: Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B. Phung, Varun Gopinatth, Qasim Shah, Alexandra T. Patterson, John C. R. Randle, Zhoumou Chen, Daniela Salvemini, David I. Lieberman, Gregory S. Whitehead, Tadeusz P. Karcz, Donald N. Cook, Kenneth A. Jacobson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a16138dcf66e0cf8b0d97c43fac4e0
http://hdl.handle.net/11577/3459804

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Structure-Activity Relationship of Heterocyclic P2Y

Autor: Young-Hwan, Jung, Veronica, Salmaso, Zhiwei, Wen, John M, Bennett, Ngan B, Phung, David I, Lieberman, Varun, Gopinatth, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson

Publikováno v: J Med Chem

A known zwitterionic, heterocyclic P2Y(14)R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2538a8e3308d6a52460a78072272a801
https://pubmed.ncbi.nlm.nih.gov/33787273

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Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y

Autor: Young-Hwan, Jung, Shanu, Jain, Varun, Gopinatth, Ngan B, Phung, Zhan-Guo, Gao, Kenneth A, Jacobson

Publikováno v: Bioorg Med Chem Lett

Various 6-alkynyl analogues of a known 3-nitro-2-(trifluoromethyl)-2H-chromene antagonist 3 of the G(q)-coupled P2Y(6) receptor (P2Y(6)R) were synthesized using a Sonogashira reaction to replace a 6-iodo group. The analogues were tested in a function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e0b3bced1f28e29dfac11377d1858be
https://pubmed.ncbi.nlm.nih.gov/33831560

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Exploration of Alternative Scaffolds for P2Y(14) Receptor Antagonists Containing a Biaryl Core

Autor: Steven Dudas, Zhan-Guo Gao, Jinha Yu, Zhiwei Wen, Tadeusz P Karcz, John M. Bennett, Kenneth A. Jacobson, Sierra Duca, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, Veronica Salmaso, Donald N. Cook, Zhoumou Chen

Publikováno v: J Med Chem

Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y(14) receptor (P2Y(14)R) antagonists were synthesized, and affinity was measured in P2Y(14)R-expressing Chinese hamster ovary cells by flow cytometry. Given this series’ l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e1e7f295e8914ed6cd6052e64fe4cb
https://europepmc.org/articles/PMC8040948/

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Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor

Autor: Kiran S. Toti, Anna Junker, Ngan B. Phung, Shanu Jain, Paola Oliva, Varun Gopinatth, Kenneth A. Jacobson, Mirko Scortichini, Clemens Dobelmann

Publikováno v: Bioorg Med Chem Lett

The G(q)-coupled P2Y(6) receptor (P2Y(6)R) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2Y(6)R agonist and P2Y(14)R partial agonist, is subject to hydrolysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e4645d3ce1a9053edf4f52e5bdc546
https://doi.org/10.1016/j.bmcl.2021.128137

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Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists

Autor: Zhan-Guo Gao, Ngan B. Phung, Shanu Jain, Varun Gopinatth, Kenneth A. Jacobson, Young-Hwan Jung

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 41:128008

Various 6-alkynyl analogues of a known 3-nitro-2-(trifluoromethyl)-2H-chromene antagonist 3 of the Gq-coupled P2Y6 receptor (P2Y6R) were synthesized using a Sonogashira reaction to replace a 6-iodo group. The analogues were tested in a functional ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eec1ccdd6ea10c1fa941db83745b74e0
https://doi.org/10.1016/j.bmcl.2021.128008

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