Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ngaisah Klar-Mohamad"'
Autor:
Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia, Kees Fluiter, Frank Baas
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC). Both initiate pro-inflammatory responses which can
Externí odkaz:
https://doaj.org/article/aa28a418a3c5487a95181f43b8fe2680
Autor:
Elon H C van Dijk, Roula Tsonaka, Ngaisah Klar-Mohamad, Diana Wouters, Aiko P J de Vries, Eiko K de Jong, Cees van Kooten, Camiel J F Boon
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180312 (2017)
A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In age-related macular degeneration, a disease that shows clinical features that overlap with CSC,
Externí odkaz:
https://doaj.org/article/a0101e70acc14cca8b314385ab78166d
Autor:
Juha Kotimaa, Cordula M. Stover, Mohamed R. Daha, Angela Koudijs, Ngaisah Klar-Mohamad, Wilhelm J. Schwaeble, Ria Faber-Krol, Joseph O'Flynn, Cees van Kooten, Karin Koekkoek
Publikováno v:
Kidney International, 94(6), 1141-1150
Properdin is the only known positive regulator of complement activation by stabilizing the alternative pathway convertase through C3 binding, thus prolonging its half-life. Recent in vitro studies suggest that properdin may act as a specific pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f39e0978b0dfec6a8974535b2da1bb
http://hdl.handle.net/1887/96163
http://hdl.handle.net/1887/96163
Autor:
Nicole N. van der Wel, Valeria Ramaglia, Trent M. Woodruff, Anita E. Grootemaat, Marit B. de Wissel, Theodosia Georgakopoulou, Patrick Ruizendaal, Jeroen P. Vreijling, Iliana Michailidou, Cees van Kooten, Daisy I. Picavet, B. Paul Morgan, R. A. Wolterman, Ngaisah Klar-Mohamad, Frank Baas, Kees Fluiter, Vinod Kumar, Aldo Jongejan
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Acta neuropathologica communications, 6(1). BioMed Central
Acta Neuropathologica Communications, 6
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Acta neuropathologica communications, 6(1). BioMed Central
Acta Neuropathologica Communications, 6
The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC). Both initiate pro-inflammatory responses which can contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2f8d84f96eaff2fb2e1cd682a1a06
Autor:
Michailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen, Georgakopoulou, Theodosia, Wissel, Marit De, Wolterman, Ruud, Ruizendaal, Patrick, Ngaisah Klar-Mohamad, Grootemaat, Anita, Picavet, Daisy, Kumar, Vinod, Kooten, Cees Van, Woodruff, Trent, B. Morgan, Wel, Nicole Van Der, Ramaglia, Valeria, Fluiter, Kees, Baas, Frank
Table S1. Expression levels of key immune genes in mice with chronic relapsing EAE showing mild or severe neurological disability and comparison with mice showing no disability. Table S2. Mouse primer sequences. Table S3. Primary antibodies, dilution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5017dcda6ca73f82e0dc574852256410
Autor:
Michailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen, Georgakopoulou, Theodosia, Wissel, Marit De, Wolterman, Ruud, Ruizendaal, Patrick, Ngaisah Klar-Mohamad, Grootemaat, Anita, Picavet, Daisy, Kumar, Vinod, Kooten, Cees Van, Woodruff, Trent, B. Morgan, Wel, Nicole Van Der, Ramaglia, Valeria, Fluiter, Kees, Baas, Frank
Figure S1. Systemic administration of C6 antisense knocks down C6 in mice. Figure S2. QPCR determination of key components of the inflammasome pathway. Figure S3. PMX205 concentrations in plasma, brain and spinal cord. Figure S4. Systemic administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e9f9b89f85caeeed443e91319554b0
Autor:
Eiko K. de Jong, Camiel J. F. Boon, Aiko P. J. de Vries, Diana Wouters, Roula Tsonaka, Ngaisah Klar-Mohamad, Elon H. C. van Dijk, Cees van Kooten
Publikováno v:
PLoS ONE, 12(7). Public Library of Science
PLoS ONE, Vol 12, Iss 7, p e0180312 (2017)
PLoS ONE
PLoS One, 12
PLoS ONE, 12(7)
PLoS One, 12, 7
PLoS ONE, Vol 12, Iss 7, p e0180312 (2017)
PLoS ONE
PLoS One, 12
PLoS ONE, 12(7)
PLoS One, 12, 7
Contains fulltext : 177971.pdf (Publisher’s version ) (Open Access) PURPOSE: A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In age-related macu
Autor:
Wilhelm J. Schwaeble, Cees van Kooten, Joseph O'Flynn, Ngaisah Klar-Mohamad, Cordula M. Stover, Juha Kotimaa, Mohamed R. Daha, Ria Faber-Krol, Angela Koudijs, Karin Koekkoek
Publikováno v:
Molecular Immunology. 102:176
Autor:
André M. Deelder, Cees van Kooten, Alexandra van Remoortere, Beatrijs Oortwijn, Anja Roos, Mohamed R. Daha, Paul J M van der Boog, Ngaisah Klar-Mohamad
Publikováno v:
Molecular Immunology. 44:966-973
IgA is found in both mucosal secretions and serum and is the dominant immunoglobulin isotype produced in humans. It exists in different molecular forms, namely monomeric IgA, dimeric IgA, polymeric IgA and secretory IgA, all exhibiting interactions w
Autor:
Juha P. Kotimaa, Maaike B. van Werkhoven, Joseph O'Flynn, Ngaisah Klar-Mohamad, Jan van Groningen, Geurt Schilders, Helma Rutjes, Mohamed R. Daha, Marc A. Seelen, Cees van Kooten
Publikováno v:
Journal of Immunological Methods, 419, 25-34. ELSEVIER SCIENCE BV
Journal of Immunological Methods, 419, 25-34
Journal of Immunological Methods, 419, 25-34
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df7efd55037cb9056ba12c180df4856
https://hdl.handle.net/1887/101444
https://hdl.handle.net/1887/101444