Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ngadhnjim Latifi"'
Autor:
Philipp Reautschnig, Nicolai Wahn, Jacqueline Wettengel, Annika E. Schulz, Ngadhnjim Latifi, Paul Vogel, Tae-Won Kang, Laura S. Pfeiffer, Christine Zarges, Ulrike Naumann, Lars Zender, Jin Billy Li, Thorsten Stafforst
Publikováno v:
Nature Biotechnology. 40:759-768
RNA base editing represents a promising alternative to genome editing. Recent approaches harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA (ADAR) to circumvent problems caused by ectopic expression of engineered editing enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fccc722c72bc8f732617b21e535164a
https://doi.org/10.1038/s41587-021-01105-0
https://doi.org/10.1038/s41587-021-01105-0
Site-directed RNA base editing enables the transient and dosable change of genetic information and represents a recent strategy to manipulate cellular processes, paving ways to novel therapeutic modalities. While tools to introduce adenosine-to-inosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb290c05afe8beb6f34ef4197931a71f
https://doi.org/10.1101/2023.02.17.528953
https://doi.org/10.1101/2023.02.17.528953
Autor:
Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Thomas Epting, Lukas Heumos, Praveen Baskaran, Jakob Admard, Nicolas Casadei, Ngadhnjim Latifi, Darina M. Siegmund, Michael S. D. Kormann, Rupert Handgretinger, Markus Mezger
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
β-hemoglobinopathies are caused by abnormal or absent production of hemoglobin in the blood due to mutations in the β-globin gene (HBB). Imbalanced expression of adult hemoglobin (HbA) induces strong anemia in patients suffering from the disease. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::e6e99b97fba607dc7af4f1dc59c9e7f7
http://link.springer.com/article/10.1038/s41598-020-66309-x
http://link.springer.com/article/10.1038/s41598-020-66309-x
Autor:
Andrés, Lamsfus-Calle, Alberto, Daniel-Moreno, Justin S, Antony, Thomas, Epting, Lukas, Heumos, Praveen, Baskaran, Jakob, Admard, Nicolas, Casadei, Ngadhnjim, Latifi, Darina M, Siegmund, Michael S D, Kormann, Rupert, Handgretinger, Markus, Mezger
Publikováno v:
Scientific Reports
β-hemoglobinopathies are caused by abnormal or absent production of hemoglobin in the blood due to mutations in the β-globin gene (HBB). Imbalanced expression of adult hemoglobin (HbA) induces strong anemia in patients suffering from the disease. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e686d274106854e9365942592ff3a74
https://pubmed.ncbi.nlm.nih.gov/32576837
https://pubmed.ncbi.nlm.nih.gov/32576837
Autor:
Justin S, Antony, Ngadhnjim, Latifi, A K M Ashiqul, Haque, Andrés, Lamsfus-Calle, Alberto, Daniel-Moreno, Sebastian, Graeter, Praveen, Baskaran, Petra, Weinmann, Markus, Mezger, Rupert, Handgretinger, Michael S D, Kormann
Publikováno v:
Molecular and Cellular Pediatrics
Background β-Thalassemia is an inherited hematological disorder caused by mutations in the human hemoglobin beta (HBB) gene that reduce or abrogate β-globin expression. Although lentiviral-mediated expression of β-globin and autologous transplanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb7b7a20ecbd44416525160ea8ff9f7a
https://pubmed.ncbi.nlm.nih.gov/30430274
https://pubmed.ncbi.nlm.nih.gov/30430274
Autor:
Petra Weinmann, Praveen Baskaran, Alberto Daniel-Moreno, Justin S. Antony, Sebastian Graeter, Michael S. D. Kormann, Markus Mezger, Rupert Handgretinger, Ngadhnjim Latifi, Andrés Lamsfus-Calle, A. K. M. Ashiqul Haque
Publikováno v:
Molecular and Cellular Pediatrics
β-Thalassemia is an inherited hematological disorder caused by mutations in the human hemoglobin beta (HBB) gene that reduce or abrogate β-globin expression. Although lentiviral-mediated expression of β-globin and autologous transplantation is a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d3bf5bf2beac301a79318014ce1a29
Autor:
Antony, Justin, Ngadhnjim Latifi, A. Haque, Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Graeter, Sebastian, Baskaran, Praveen, Weinmann, Petra, Mezger, Markus, Handgretinger, Rupert, Kormann, Michael
Figure S1. Strategy for targeting the promoter and IVS1–110 mutation of the HBB gene. A) The promoter region of HBB gene targeted with three different gene-editing tools, HBBIVS1–110 targeted with CRISPR/Cas9. B) The design of three different gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3ddd8fff5bee692b0b30af030c2cf3
Autor:
A. K. M. Ashiqul Haque, Julie Laval, Brigitta Loretz, Ngadhnjim Latifi, Claus-Michael Lehr, Christian Seitz, Elvira Sondo, Patrick Schlegel, Hanzey Yasar, Anjali Ralhan, Alexander Dewerth, Rupert Handgretinger, Petra Weinmann, Justin S. Antony, Nicoletta Pedemonte, Brian Weidensee, Joachim Riethmüller, Michael S. D. Kormann, Georg R Schweizer
Publikováno v:
Scientific Reports
Scientific reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Gene therapy has always been a promising therapeutic approach for Cystic Fibrosis (CF). However, numerous trials using DNA or viral vectors encoding the correct protein resulted in a general low efficacy. In the last years, chemically modified messen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc280888572fbbba3369380a44485283
Autor:
Rafail Nikolaos Tasakis, Anna S. Stroppel, Alfred Hanswillemenke, Ngadhnjim Latifi, F. Nina Papavasiliou, Thorsten Stafforst
Publikováno v:
Nucleic Acids Research
The SNAP-ADAR tool enables precise and efficient A-to-I RNA editing in a guideRNA-dependent manner by applying the self-labeling SNAP-tag enzyme to generate RNA-guided editases in cell culture. Here, we extend this platform by combining the SNAP-tagg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df787cedf96d1aaf28bcf108315d40b4