Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Ng Shyh‐Chang"'
Autor:
Lingmin Liang, Yao Tian, Lin Feng, Chaoqun Wang, Guihai Feng, Glyn Nigel Stacey, Ng Shyh-Chang, Jun Wu, Baoyang Hu, Wei Li, Jie Hao, Liu Wang, Yukai Wang
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2022)
Abstract Background Midbrain dopaminergic (DA) progenitors derived from human pluripotent stem cells are considered to be a promising treatment for Parkinson’s disease (PD). However, the differentiation process produces undesired cell types, which
Externí odkaz:
https://doaj.org/article/ebed11704cad400aa106fc7a921062be
Autor:
Lanfang Luo, Yan‐Jiang Benjamin Chua, Taoyan Liu, Kun Liang, Min‐Wen Jason Chua, Wenwu Ma, Jun‐Wei Goh, Yuefan Wang, Jiali Su, Ying Swan Ho, Chun‐Wei Li, Ke Hui Liu, Bin Tean Teh, Kang Yu, Ng Shyh‐Chang
Publikováno v:
Advanced Science, Vol 10, Iss 21, Pp n/a-n/a (2023)
Abstract It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigg
Externí odkaz:
https://doaj.org/article/daad7b1142a446e7a5b8ec6dee2ed92d
Autor:
Chun‐wei Li, Kang Yu, Ng Shyh‐Chang, Zongmin Jiang, Taoyan Liu, Shilin Ma, Lanfang Luo, Lu Guang, Kun Liang, Wenwu Ma, Hefan Miao, Wenhua Cao, Ruirui Liu, Ling‐juan Jiang, Song‐lin Yu, Chao Li, Hui‐jun Liu, Long‐yu Xu, Rong‐ji Liu, Xin‐yuan Zhang, Gao‐shan Liu
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 781-794 (2022)
Abstract Age‐associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing, adipose inflammation leads to the redistribution of fat to the
Externí odkaz:
https://doaj.org/article/3e39defbb42c4a7ea134de7c1ad54a66
Autor:
Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang, Yang Yu, Pengze Yan, Chuqian Liang, Jie Ren, Moshi Song, Qian Zhao, Jinghui Lei, Yusheng Cai, Jiaming Li, Kaowen Yan, Zeming Wu, Qun Chu, Jingyi Li, Si Wang, Chunyi Li, Jing-Dong J. Han, Reyna Hernandez-Benitez, Ng Shyh-Chang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be har
Externí odkaz:
https://doaj.org/article/6ac02f71219641f79b60761ec9145431
Autor:
Tong Ming Liu, Ege Deniz Yildirim, Pin Li, Hai Tong Fang, Vinitha Denslin, Vibhor Kumar, Yuin Han Loh, Eng Hin Lee, Simon M. Cool, Bin Tean Teh, James H. Hui, Bing Lim, Ng Shyh-Chang
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 210-225 (2020)
Summary: The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate incr
Externí odkaz:
https://doaj.org/article/4d9d3e38c78343fd95dc58634ee62cac
Autor:
Chun‐wei Li, Kang Yu, Ng Shyh‐Chang, Guo‐xun Li, Ling‐juan Jiang, Song‐lin Yu, Long‐yu Xu, Rong‐ji Liu, Zi‐jian Guo, Hai‐yan Xie, Rong‐rong Li, Jie Ying, Kang Li, Dong‐jing Li
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 3, Pp 586-600 (2019)
Abstract Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a severe threat to skeletal muscle health and function. To date, experimental evidence suggests that ageing‐related subclinical inflammation could be
Externí odkaz:
https://doaj.org/article/0935a49aaaef413f9e7083574d024830
Autor:
Xing Zhang, Zunpeng Liu, Xiaoqian Liu, Si Wang, Yiyuan Zhang, Xiaojuan He, Shuhui Sun, Shuai Ma, Ng Shyh-Chang, Feng Liu, Qiang Wang, Xiaoqun Wang, Lin Liu, Weiqi Zhang, Moshi Song, Guang-Hui Liu, Jing Qu
Publikováno v:
Protein & Cell, Vol 10, Iss 9, Pp 649-667 (2019)
Abstract RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human
Externí odkaz:
https://doaj.org/article/78ebbfa21d70435a852ab640b5b98b6f
Autor:
Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Chan, Likun Wei, Siew Mei Chin, Ajijur Azad, Alex Bai-Liang He, Anskar Y. H. Leung, Mengsu Yang, Ng Shyh-Chang, William C. Cho, Jiahai Shi, Minh T. N. Le
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.
Externí odkaz:
https://doaj.org/article/350bd6e6bc6e47cb83dee5c809576fb8
Autor:
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 721-736 (2017)
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation o
Externí odkaz:
https://doaj.org/article/c7e10a401bf44c62bebdf01874f9fdbe
Autor:
Wen Cai Zhang, Tan Min Chin, Henry Yang, Min En Nga, Declan Patrick Lunny, Edwin Kok Hao Lim, Li Li Sun, Yin Huei Pang, Yi Ning Leow, Shanneen Rossellini Y Malusay, Priscilla Xin Hui Lim, Jeravan Zili Lee, Benedict Jian Wei Tan, Ng Shyh-Chang, Elaine Hsuen Lim, Wan Teck Lim, Daniel Shao Weng Tan, Eng Huat Tan, Bee Choo Tai, Ross Andrew Soo, Wai Leong Tam, Bing Lim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung canc
Externí odkaz:
https://doaj.org/article/a77285cd13d847d6a9987229f6e39d6d