In silico prediction of the granzyme B degradome

Autor: Wee Lawrence JK, Er Esmond PS, Ng Lisa FP, Tong JC

Publikováno v: BMC Genomics, Vol 12, Iss Suppl 3, p S11 (2011)

Abstract Background Granzyme B is a serine protease which cleaves at unique tetrapeptide sequences. It is involved in several signaling cross-talks with caspases and functions as a pivotal mediator in a broad range of cellular processes such as apopt

Externí odkaz: https://doaj.org/article/7a83675242c6481885eb40dca2dde98a

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection

Autor: Krishna Murthy Karuturi R, Tan Jenny, Neo Soek-Ying, Tang Kin-Fai, Ooi Eng-Eong, Hibberd Martin L, Ng Lisa FP, Vega Vinsensius B, Chia Jer-Ming, Liu Edison T, Ren Ee-Chee

Publikováno v: BMC Infectious Diseases, Vol 4, Iss 1, p 34 (2004)

Abstract Background The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently sh

Externí odkaz: https://doaj.org/article/733d57b22c514f638d070ccea4fb6ccc

Crosstalk between CD64⁺MHCII⁺ macrophages and CD4⁺ T cells drives joint pathology during chikungunya.

Autor: Lum, Fok-Moon, Chan, Yi-Hao, Teo, Teck-Hui, Becht, Etienne, Amrun, Siti Naqiah, Teng, Karen WW, Hartimath, Siddesh V, Yeo, Nicholas KW, Yee, Wearn-Xin, Ang, Nicholas, Torres-Ruesta, Anthony M, Fong, Siew-Wai, Goggi, Julian L, Newell, Evan W, Renia, Laurent, Carissimo, Guillaume, Ng, Lisa FP

Publikováno v: EMBO Molecular Medicine; Mar2024, Vol. 16 Issue 3, p641-663, 23p

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Autor: Bastard, Paul, Vazquez, Sara, Liu, Jamin, Laurie, Matthew T, Wang, Chung Yu, Gervais, Adrian, Le Voyer, Tom, Bizien, Lucy, Zamecnik, Colin, Philippot, Quentin, Rosain, Jérémie, Catherinot, Emilie, Willmore, Andrew, Mitchell, Anthea M, Bair, Rebecca, Garçon, Pierre, Kenney, Heather, Fekkar, Arnaud, Salagianni, Maria, Poulakou, Garyphallia, Siouti, Eleni, Sahanic, Sabina, Tancevski, Ivan, Weiss, Günter, Nagl, Laurenz, Manry, Jérémy, Duvlis, Sotirija, Arroyo-Sánchez, Daniel, Paz Artal, Estela, Rubio, Luis, Perani, Cristiano, Bezzi, Michela, Sottini, Alessandra, Quaresima, Virginia, Roussel, Lucie, Vinh, Donald C, Reyes, Luis Felipe, Garzaro, Margaux, Hatipoglu, Nevin, Boutboul, David, Tandjaoui-Lambiotte, Yacine, Borghesi, Alessandro, Aliberti, Anna, Cassaniti, Irene, Venet, Fabienne, Monneret, Guillaume, Halwani, Rabih, Sharif-Askari, Narjes Saheb, Danielson, Jeffrey, Burrel, Sonia, Morbieu, Caroline, Stepanovskyy, Yurii, Bondarenko, Anastasia, Volokha, Alla, Boyarchuk, Oksana, Gagro, Alenka, Neuville, Mathilde, Neven, Bénédicte, Keles, Sevgi, Hernu, Romain, Bal, Antonin, Novelli, Antonio, Novelli, Giuseppe, Saker, Kahina, Ailioaie, Oana, Antolí, Arnau, Jeziorski, Eric, Rocamora-Blanch, Gemma, Teixeira, Carla, Delaunay, Clarisse, Lhuillier, Marine, Le Turnier, Paul, Zhang, Yu, Mahevas, Matthieu, Pan-Hammarström, Qiang, Abolhassani, Hassan, Bompoil, Thierry, Dorgham, Karim, COVID HGE consortium †, French COVID study group †, COMET consortium †, Gorochov, Guy, Laouenan, Cédric, Rodríguez-Gallego, Carlos, Ng, Lisa FP, Renia, Laurent, Pujol, Aurora, Belot, Alexandre, Raffi, François, Allende, Luis M, Martinez-Picado, Javier, Ozcelik, Tayfun, Imberti, Luisa, Notarangelo, Luigi D, Troya, Jesus, Solanich, Xavier, Zhang, Shen-Ying, Puel, Anne, Wilson, Michael R

Publikováno v: Science immunology, vol 7, iss 74

Life-threatening 'breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::fa8ad2dd0c60626dc424a95cb874a12d
https://escholarship.org/uc/item/8628s3dx

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

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Petter, Bruhns, Pierre, Cerf-Bensussan, Nadine, Cumano, Ana, D’Enfert, Christophe, Deriano, Ludovic, Dillies, Marie-Agnès, Di Santo, James, Dromer, Françoise, Eberl, Gérard, Enninga, Jost, Gomperts-Boneca, Ivo, Hasan, Milena, Hedestam, Gunilla Karlsson, Hercberg, Serge, Ingersoll, Molly A, Lantz, Olivier, Kenny, Rose Anne, Ménager, Mickaël, Michel, Frédérique, Patin, Etienne, Pellegrini, Sandra, Rausell, Antonio, Rieux-Laucat, Frédéric, Rogge, Lars, Fontes, Magnus, Sakuntabhai, Anavaj, Schwartz, Olivier, Schwikowski, Benno, Shorte, Spencer, Tangy, Frédéric, Toubert, Antoine, Touvier, Mathilde, Ungeheuer, Marie-Noëlle, Zimmer, Christophe, Albert, Matthew L., Alavoine, Loubna, Behillil, Sylvie, Burdet, Charles, Charpentier, Charlotte, Dechanet, Aline, Ecobichon, Jean-Luc, Frezouls, Wahiba, Houhou, Nadhira, Lehacaut, Jonathan, Lucet, Jean-Christophe, Manchon, Pauline, Nouroudine, Mariama, Quintin, Caroline, Thy, Michael, van der Werf, Sylvie, Vignali, Valérie, Chahine, Abir, Waucquier, Nawal, Migaud, Maria-Claire, Djossou, Félix, Mergeay-Fabre, Mayka, Lucarelli, Aude, Demar, Magalie, Bruneau, Léa, Gérardin, Patrick, Maillot, Adrien, Payet, Christine, Laviolle, Bruno, Paris, Christophe, Desille-Dugast, Mireille, Fouchard, Julie, Pistone, Thierry, Perreau, Pauline, Gissot, Valérie, Le Goas, Carole, Montagne, Samatha, Richard, Lucie, Bouiller, Kévin, Desmarets, Maxime, Meunier, Alexandre, Lefévre, Benjamin, Jeulin, Hélène, Legrand, Karine, Lomazzi, Sandra, Tardy, Bernard, Gagneux-Brunon, Amandine, Bertholon, Frédérique, Botelho-Nevers, Elisabeth, Kouakam, Christelle, Leturque, Nicolas, Roufai, Layidé, Amat, Karine, Espérou, Hélène, Hendou, Samia, van Agtmael, Michiel, Algera, Anne Geke, Appelman, Brent, van Baarle, Frank, Bax, Diane, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Buis, David T.P., Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul, Fleuren, Lucas, Geijtenbeek, Suzanne Geerlings Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Lim, Endry H.T., van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J., Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A.I., van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C.F.J., Schinkel, Michiel, Schultz, Marcus J., Schrauwen, Femke A.P., Schuurmans, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M, Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise, Volleman, Carolien, de Vries, Heder, Vught, Lonneke A., van Vugt, Michèle, Wouters, Dorien, Zwinderman, A. H (Koos, Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., Al-Muhsen, Saleh, Al-Mulla, Fahd, Arias, Andrés A., Bogunovic, Dusan, Bolze, Alexandre, Bryceson, Yenan, Bustamante, Carlos D., Butte, Manish J., Chakravorty, Samya, Christodoulou, John, Constantinescu, Stefan N., Cooper, Megan A., Desai, Murkesh, Drolet, Beth A., El Baghdadi, Jamila, Espinosa-Padilla, Sara, Froidure, Antoine, Henrickson, Sarah E., Hsieh, Elena W.Y., Husebye, Eystein S., Imai, Kohsuke, Itan, Yuval, Jarvis, Erich D., Karamitros, Timokratis, Ku, Cheng-Lung, Ling, Yun, Lucas, Carrie L., Maniatis, Tom, Maródi, László, Milner, Joshua D., Mironska, Kristina, Ng, Lisa F.P., Novelli, Antonio, Novelli, Giuseppe, de Diego, Rebeca Perez, Renia, Laurent, Resnick, Igor, Sancho-Shimizu, Vanessa, Seppänen, Mikko R.J., Shahrooei, Mohammed, Slaby, Ondrej, Abou Tayoun, Ahmad, Ramaswamy, Sathishkumar, Turvey, Stuart E, Uddin, K M Furkan, Uddin, Mohammed J., von Bernuth, Horst, Zawadzki, Pawel, Nadif, Rachel, Goldberg, Marcel, Ozguler, Anna, Henny, Joseph, Lemonnier, Sylvie, Coeuret-Pellicer, Mireille, Le Got, Stéphane, Tzourio, Christophe, Dufouil, Carole, Soumaré, Aïcha, Lachaize, Morgane, Fievet, Nathalie, Flaig, Amandine, Martin, Fernando, Bonneaudeau, Brigitte, Cannet, Dorothée, Gallian, Pierre, Jeanne, Michel, Perroquin, Magali, Hamzeh-Cognasse, Hind

Publikováno v: Science Immunology
Science Immunology, 2021, 6 (62), pp.eabl4340. ⟨10.1126/sciimmunol.abl4340⟩
ISI atlas of science. Immunology 6 (2021). doi:10.1126/sciimmunol.abl4340
info:cnr-pdr/source/autori:Bastard P.; Gervais A.; Le Voyer T.; Rosain J.; Philippot Q.; Manry J.; Michailidis E.; Hoffmann H.-H.; Eto S.; Garcia-Prat M.; Bizien L.; Parra-Martinez A.; Yang R.; Haljasmagi L.; Migaud M.; Sarekannu K.; Maslovskaja J.; Prost N.D.; Tandjaoui-Lambiotte Y.; Luyt C.-E.; Amador-Borrero B.; Gaudet A.; Poissy J.; Morel P.; Richard P.; Cognasse F.; Troya J.; Trouillet-Assant S.; Belot A.; Saker K.; Garcon P.; Riviere J.G.; Lagier J.-C.; Gentile S.; Rosen L.B.; Shaw E.; Morio T.; Tanaka J.; Dalmau D.; Tharaux P.-L.; Sene D.; Stepanian A.; Megarbane B.; Triantafyllia V.; Fekkar A.; Heath J.R.; Franco J.L.; Anaya J.-M.; Sole-Violan J.; Imberti L.; Biondi A.; Bonfanti P.; Castagnoli R.; Delmonte O.M.; Zhang Y.; Snow A.L.; Holland S.M.; Biggs C.M.; Moncada-Velez M.; Arias A.A.; Lorenzo L.; Boucherit S.; Coulibaly B.; Anglicheau D.; Planas A.M.; Haerynck F.; Duvlis S.; Nussbaum R.L.; Ozcelik T.; Keles S.; Bousfiha A.A.; Bakkouri J.E.; Ramirez-Santana C.; Paul S.; Pan-Hammarstrom Q.; Hammarstrom L.; Dupont A.; Kurolap A.; Metz C.N.; Aiuti A.; Casari G.; Lampasona V.; Ciceri F.; Barreiros L.A.; Dominguez-Garrido E.; Vidigal M.; Zatz M.; Beek D.V.D.; Sahanic S.; Tancevski I.; Stepanovskyy Y.; Boyarchuk O.; Nukui Y.; Tsumura M.; Vidaur L.; Tangye S.G.; Burrel S.; Duffy D.; Quintana-Murci L.; Klocperk A.; Kann N.Y.; Shcherbina A.; Lau Y.-L.; Leung D.; Coulongeat M.; Marlet J.; Koning R.; Reyes L.F.; Chauvineau-Grenier A.; Venet F.; Monneret G.; Nussenzweig M.C.; Arrestier R.; Boudhabhay I.; Baris-Feldman H.; Hagin D.; Wauters J.; Meyts I.; Dyer A.H.; Kennelly S.P.; Bourke N.M.; Halwani R.; Sharif-Askari N.S.; Dorgham K.; Sallette J.; Sedkaoui S.M.; AlKhater S.; Rigo-Bonnin R.; Morandeira F.; Roussel L.; Vinh D.C.; Ostrowski S.R.; Condino-Neto A.; Prando C.; Bondarenko A.; Spaan A.N.; Gilardin L.; Fellay J.; Lyonnet S.; Bilguvar K.; Lifton R.P.; Mane S.; Anderson M.S.; Boisson B.; Beziat V.; Zhang S.-Y.; Andreakos E.; Hermine O.; Pujol A.; Peterson P.; Mogensen T.H.; Rowen L.; Mond J.; Debette S.; Lamballerie X.D.; Duval X.; Mentre F.; Zins M.; Soler-Palacin P.; Colobran R.; Gorochov G.; Solanich X.; Susen S.; Martinez-Picado J.; Raoult D.; Vasse M.; Gregersen P.K.; Piemonti L.; Rodriguez-Gallego C.; Notarangelo L.D.; Su H.C.; Kisand K.; Okada S.; Puel A.; Jouanguy E.; Rice C.M.; Tiberghien P.; Zhang Q.; Cobat A.; Abel L.; Casanova J.-L./titolo:Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths/doi:10.1126%2Fsciimmunol.abl4340/rivista:ISI atlas of science. Immunology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Science Immunology, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4340⟩
Science immunology, 6(62):eabl4340. American Association for the Advancement of Science
Dipòsit Digital de la UB
Universidad de Barcelona
Science Immunology, American Association for the Advancement of Science, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4340⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Manry, J, Michailidis, E, Hoffmann, H H, Eto, S, Garcia-Prat, M, Bizien, L, Parra-Martínez, A, Yang, R, Haljasmägi, L, Migaud, M, Särekannu, K, Maslovskaja, J, Prost, N D, Tandjaoui-Lambiotte, Y, Luyt, C E, Amador-Borrero, B, Gaudet, A, Poissy, J, Morel, P, Richard, P, Cognasse, F, Troya, J, Trouillet-Assant, S, Belot, A, Saker, K, Garçon, P, Rivière, J G, Lagier, J C, Gentile, S, Rosen, L B, Shaw, E, Morio, T, Tanaka, J, Dalmau, D, Tharaux, P L, Sene, D, Stepanian, A, Megarbane, B, Triantafyllia, V, Fekkar, A, Heath, J R, Franco, J L, Anaya, J M, Mogensen, T H, Casanova, J L, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group & Imagine COVID Group 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science Immunology, vol. 6, no. 62, 4340 . https://doi.org/10.1126/sciimmunol.abl4340
Science immunology, vol. 6, no. 62, pp. eabl4340
French COVID Cohort Study Group, NIAID Immune Response to COVID Group, Danish CHGE, COVID Human Genetic Effort, HGID Lab, COVID-STORM Clinicians, NH-COVAIR Study Group, The Danish Blood Donor Study (DBDS), Imagine COVID-Group, The Milieu Intérieur Consortium, Amsterdam UMC Covid-19 Biobank, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, CoV-Contact Cohort, St James's Hospital, SARS CoV2 Interest group & COVID Clinicians 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science immunology, vol. 6, no. 62, eabl4340 . https://doi.org/10.1126/sciimmunol.abl4340
SCIENCE IMMUNOLOGY
COVID Human Genetic Effort, Imagine COVID-Group, Danish CHGE, CONSTANCES cohort, Etablissement du Sang study group, St James's Hospital, SARS CoV2 Interest group, 3C-Dijon Study, COVID Clinicians, CoV-Contact Cohort, NIAID Immune Response to COVID Group, Cerba HealthCare, French COVID Cohort Study Group, HGID Lab, COVID-STORM Clinicians, NH-COVAIR Study Group, The Danish Blood Donor Study (DBDS), The Milieu Intérieur Consortium & Amsterdam UMC Covid-19 Biobank 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science immunology, vol. 6, no. 62, eabl4340 . https://doi.org/10.1126/sciimmunol.abl4340, https://doi.org/10.1126/sciimmunol.abl4340
Digital.CSIC. Repositorio Institucional del CSIC
instname

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9782ed7fd520b02e3e125e6fda82e43d
https://hal.science/hal-03358792/file/BPH_SI_2021_Bastard.pdf