Ex vivo metabolism kinetics of primary to secondary bile acids via a physiologically relevant human faecal microbiota model.

Autor: Ng DZW; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore., Low A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Tan AJH; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore., Ong JH; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore., Kwa WT; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Lee JWJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, E7, 15 Kent Ridge Crescent, Singapore, 119276, Singapore; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore. Electronic address: jonathanlee@nus.edu.sg., Chan ECY; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore. Electronic address: phaccye@nus.edu.sg.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2024 Aug 25; Vol. 399, pp. 111140. Date of Electronic Publication: 2024 Jul 09.

Sensitive LC-MS/MS method for the temporal profiling of bile acids, fatty acids and branched-chain alpha-keto acids in maternal plasma during pregnancy and cord blood plasma at delivery.

Autor: Ng DZW; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore., Lee SXY; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore., Ooi DSQ; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore., Ta LDH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore., Yap GC; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore., Tay CJX; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore., Huang CH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore., Tham EH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore; Division of Allergy & Immunology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Loo EXL; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Shek LPC; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Goh A; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Bever HPSV; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Teoh OH; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Lee YS; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Division of Paediatric Endocrinology and Diabetes, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Yap F; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Tan KH; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Chong YS; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Obstetrics & Gynaecology, National University of Singapore, Singapore., Chan SY; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Obstetrics & Gynaecology, National University of Singapore, Singapore., Eriksson JG; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Obstetrics & Gynaecology, National University of Singapore, Singapore; Folkhälsan Research Center, Helsinki, Finland and Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Godfrey KM; MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Lee BW; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore. Electronic address: paeleebw@nus.edu.sg., Chan ECY; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore. Electronic address: eric.chan@nus.edu.sg.

Publikováno v: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2023 Jul 01; Vol. 547, pp. 117449. Date of Electronic Publication: 2023 Jun 17.

Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach.

Autor: Lenard, Alexander, Hermann, Simon A., Stoll, Felicitas, Burhenne, Juergen, Foerster, Kathrin I., Mikus, Gerd, Meid, Andreas D., Haefeli, Walter E., Blank, Antje

Publikováno v: Cardiovascular Drugs & Therapy; Aug2024, Vol. 38 Issue 4, p747-756, 10p

Development and verification of a physiologically based pharmacokinetic model of dronedarone and its active metabolite N‐desbutyldronedarone: Application to prospective simulation of complex drug–drug interaction with rivaroxaban.

Autor: Leow, Jacqueline Wen Hui, Ang, Xiao Jun, Chan, Eric Chun Yong

Publikováno v: British Journal of Clinical Pharmacology; Jun2023, Vol. 89 Issue 6, p1873-1890, 18p

A review of pancreatic cyst fluid analysis in the differential diagnosis of pancreatic cyst lesions.

Autor: Boot, Christopher

Publikováno v: Annals of Clinical Biochemistry; Mar2014, Vol. 51 Issue 2, p151-166, 16p, 1 Diagram, 3 Charts